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F6INB4

- F6INB4_9SPHN

UniProt

F6INB4 - F6INB4_9SPHN

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Protein

Malate synthase G

Gene

glcB

Organism
Novosphingobium sp. PP1Y
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.UniRule annotationSAAS annotation

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.UniRule annotationSAAS annotation

Cofactori

Note: Magnesium.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei118 – 1181Acetyl-CoA; via carbonyl oxygenUniRule annotation
Binding sitei254 – 2541Acetyl-CoAUniRule annotation
Binding sitei291 – 2911Acetyl-CoAUniRule annotation
Active sitei318 – 3181Proton acceptorUniRule annotation
Binding sitei318 – 3181GlyoxylateUniRule annotation
Metal bindingi410 – 4101MagnesiumUniRule annotation
Binding sitei410 – 4101GlyoxylateUniRule annotation
Metal bindingi438 – 4381MagnesiumUniRule annotation
Binding sitei519 – 5191Acetyl-CoA; via carbonyl oxygenUniRule annotation
Active sitei609 – 6091Proton donorUniRule annotation

GO - Molecular functioni

  1. malate synthase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-HAMAP
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseImported, Transferase

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciNSP702113:GJD2-1971-MONOMER.
UniPathwayiUPA00703; UER00720.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthase GUniRule annotation (EC:2.3.3.9UniRule annotation)
Gene namesi
Name:glcBUniRule annotation
ORF Names:PP1Y_AT20390Imported
OrganismiNovosphingobium sp. PP1YImported
Taxonomic identifieri702113 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeNovosphingobium
ProteomesiUP000009242: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei595 – 5951Cysteine sulfenic acid (-SOH)UniRule annotation

Keywords - PTMi

OxidationUniRule annotation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni125 – 1262Acetyl-CoA bindingUniRule annotation
Regioni435 – 4384Glyoxylate bindingUniRule annotation

Sequence similaritiesi

Belongs to the malate synthase family. GlcB subfamily.UniRule annotation

Phylogenomic databases

KOiK01638.

Family and domain databases

Gene3Di2.170.170.11. 2 hits.
HAMAPiMF_00641. Malate_synth_G.
InterProiIPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01345. malate_syn_G. 1 hit.

Sequencei

Sequence statusi: Complete.

F6INB4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTQRVERSGL QIDAGLAAFV EEKVLAPIGQ DTDAFWSGFA QLLARFAPRN
60 70 80 90 100
RELLEKRDHL QSQIDAWHMS RAGRPIEQGE YQAFLQDIGY LVPEPEVFSI
110 120 130 140 150
GTRNVDPEIA TMAGPQLVVP VLNARFLLNA ANARWGSLYD AFYGTDALDA
160 170 180 190 200
APAQGKGYDP VRGAAVIAEG RKFLDKALPL ASGSWADVDS LEVTLVDPDQ
210 220 230 240 250
CVGETRKGCL FKSNGLHIEI VVDPSSQVGA TDKAGISDIV LEAALTTIVD
260 270 280 290 300
LEDSVAAVDA EDKLLAYSNW LGVIRGDLTD TFEKGGQTLT RELAGNKVVT
310 320 330 340 350
VPTGEAQELP GRSLLFVRNV GHLMTNPAIL LPDGSEIPEG IMDAVITSAI
360 370 380 390 400
SAQDVKGMTR YGNSRKGSIY IVKPKMHGPE ECSFTNDLFD AVEDLLQLPR
410 420 430 440 450
NTVKVGVMDE ERRTSANLAA CIHAVKDRIV FINTGFLDRT GDEIHTSMRA
460 470 480 490 500
GPMIRKSAIK GSTWIAAYEK RNVAIGLRHG LSGVAQIGKG MWAAPDMMRD
510 520 530 540 550
MMEQKVGHPR TGANTAWVPS PTAATLHAMH YHEVDVFGLR EGIAAEEIPG
560 570 580 590 600
LDLLLQIPLA DGANWSEDEV REELENNAQG LLGYVVRWID QGVGCSKVPD
610 620 630 640 650
INDVGLMEDR ATLRISSQHM ANWLLHGVCT EAQVMDALKR MAEKVDAQNA
660 670 680 690 700
GDPLYAPMAG NWDTSLAFKA ACDLVFKGVE QPSGYTEPLL HAWRLKKKSA

LVTA
Length:704
Mass (Da):76,484
Last modified:July 27, 2011 - v1
Checksum:iCDA840251055D982
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR856862 Genomic DNA. Translation: CCA92916.1.
RefSeqiWP_013833231.1. NC_015580.1.
YP_004534734.1. NC_015580.1.

Genome annotation databases

EnsemblBacteriaiCCA92916; CCA92916; PP1Y_AT20390.
GeneIDi10715386.
KEGGinpp:PP1Y_AT20390.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR856862 Genomic DNA. Translation: CCA92916.1 .
RefSeqi WP_013833231.1. NC_015580.1.
YP_004534734.1. NC_015580.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCA92916 ; CCA92916 ; PP1Y_AT20390 .
GeneIDi 10715386.
KEGGi npp:PP1Y_AT20390.

Phylogenomic databases

KOi K01638.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00720 .
BioCyci NSP702113:GJD2-1971-MONOMER.

Family and domain databases

Gene3Di 2.170.170.11. 2 hits.
HAMAPi MF_00641. Malate_synth_G.
InterProi IPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view ]
Pfami PF01274. Malate_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF51645. SSF51645. 1 hit.
TIGRFAMsi TIGR01345. malate_syn_G. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "De novo sequencing and assembly of the whole genome of Novosphingobium sp. strain PP1Y."
    D'Argenio V., Petrillo M., Cantiello P., Naso B., Cozzuto L., Notomista E., Paolella G., Di Donato A., Salvatore F.
    J. Bacteriol. 193:4296-4296(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiF6INB4_9SPHN
AccessioniPrimary (citable) accession number: F6INB4
Entry historyi
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3