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F6INB4

- F6INB4_9SPHN

UniProt

F6INB4 - F6INB4_9SPHN

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Protein
Malate synthase G
Gene
glcB, PP1Y_AT20390
Organism
Novosphingobium sp. PP1Y
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA By similarity.UniRule annotationSAAS annotations

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.UniRule annotationSAAS annotations

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei118 – 1181Acetyl-CoA; via carbonyl oxygen By similarityUniRule annotation
Binding sitei254 – 2541Acetyl-CoA By similarityUniRule annotation
Binding sitei291 – 2911Acetyl-CoA By similarityUniRule annotation
Active sitei318 – 3181Proton acceptor By similarityUniRule annotation
Binding sitei318 – 3181Glyoxylate By similarityUniRule annotation
Metal bindingi410 – 4101Magnesium By similarityUniRule annotation
Binding sitei410 – 4101Glyoxylate By similarityUniRule annotation
Metal bindingi438 – 4381Magnesium By similarityUniRule annotation
Binding sitei519 – 5191Acetyl-CoA; via carbonyl oxygen By similarityUniRule annotation
Active sitei609 – 6091Proton donor By similarityUniRule annotation

GO - Molecular functioni

  1. malate synthase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-HAMAP
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseImported, Transferase

Keywords - Biological processi

Glyoxylate bypassUniRule annotationSAAS annotations, Tricarboxylic acid cycleUniRule annotationSAAS annotations

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciNSP702113:GJD2-1971-MONOMER.
UniPathwayiUPA00703; UER00720.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthase GUniRule annotation (EC:2.3.3.9UniRule annotation)
Gene namesi
Name:glcBUniRule annotation
ORF Names:PP1Y_AT20390Imported
OrganismiNovosphingobium sp. PP1YImported
Taxonomic identifieri702113 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeNovosphingobium
ProteomesiUP000009242: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei595 – 5951Cysteine sulfenic acid (-SOH) By similarityUniRule annotation

Keywords - PTMi

OxidationUniRule annotation

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni125 – 1262Acetyl-CoA binding By similarityUniRule annotation
Regioni435 – 4384Glyoxylate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK01638.

Family and domain databases

Gene3Di2.170.170.11. 2 hits.
HAMAPiMF_00641. Malate_synth_G.
InterProiIPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01345. malate_syn_G. 1 hit.

Sequencei

Sequence statusi: Complete.

F6INB4-1 [UniParc]FASTAAdd to Basket

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MTQRVERSGL QIDAGLAAFV EEKVLAPIGQ DTDAFWSGFA QLLARFAPRN    50
RELLEKRDHL QSQIDAWHMS RAGRPIEQGE YQAFLQDIGY LVPEPEVFSI 100
GTRNVDPEIA TMAGPQLVVP VLNARFLLNA ANARWGSLYD AFYGTDALDA 150
APAQGKGYDP VRGAAVIAEG RKFLDKALPL ASGSWADVDS LEVTLVDPDQ 200
CVGETRKGCL FKSNGLHIEI VVDPSSQVGA TDKAGISDIV LEAALTTIVD 250
LEDSVAAVDA EDKLLAYSNW LGVIRGDLTD TFEKGGQTLT RELAGNKVVT 300
VPTGEAQELP GRSLLFVRNV GHLMTNPAIL LPDGSEIPEG IMDAVITSAI 350
SAQDVKGMTR YGNSRKGSIY IVKPKMHGPE ECSFTNDLFD AVEDLLQLPR 400
NTVKVGVMDE ERRTSANLAA CIHAVKDRIV FINTGFLDRT GDEIHTSMRA 450
GPMIRKSAIK GSTWIAAYEK RNVAIGLRHG LSGVAQIGKG MWAAPDMMRD 500
MMEQKVGHPR TGANTAWVPS PTAATLHAMH YHEVDVFGLR EGIAAEEIPG 550
LDLLLQIPLA DGANWSEDEV REELENNAQG LLGYVVRWID QGVGCSKVPD 600
INDVGLMEDR ATLRISSQHM ANWLLHGVCT EAQVMDALKR MAEKVDAQNA 650
GDPLYAPMAG NWDTSLAFKA ACDLVFKGVE QPSGYTEPLL HAWRLKKKSA 700
LVTA 704
Length:704
Mass (Da):76,484
Last modified:July 27, 2011 - v1
Checksum:iCDA840251055D982
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FR856862 Genomic DNA. Translation: CCA92916.1.
RefSeqiWP_013833231.1. NC_015580.1.
YP_004534734.1. NC_015580.1.

Genome annotation databases

EnsemblBacteriaiCCA92916; CCA92916; PP1Y_AT20390.
GeneIDi10715386.
KEGGinpp:PP1Y_AT20390.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FR856862 Genomic DNA. Translation: CCA92916.1 .
RefSeqi WP_013833231.1. NC_015580.1.
YP_004534734.1. NC_015580.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCA92916 ; CCA92916 ; PP1Y_AT20390 .
GeneIDi 10715386.
KEGGi npp:PP1Y_AT20390.

Phylogenomic databases

KOi K01638.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00720 .
BioCyci NSP702113:GJD2-1971-MONOMER.

Family and domain databases

Gene3Di 2.170.170.11. 2 hits.
HAMAPi MF_00641. Malate_synth_G.
InterProi IPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view ]
Pfami PF01274. Malate_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF51645. SSF51645. 1 hit.
TIGRFAMsi TIGR01345. malate_syn_G. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "De novo sequencing and assembly of the whole genome of Novosphingobium sp. strain PP1Y."
    D'Argenio V., Petrillo M., Cantiello P., Naso B., Cozzuto L., Notomista E., Paolella G., Di Donato A., Salvatore F.
    J. Bacteriol. 193:4296-4296(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiF6INB4_9SPHN
AccessioniPrimary (citable) accession number: F6INB4
Entry historyi
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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