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Protein

Isocitrate dehydrogenase [NADP]

Gene

VIT_14s0066g00950

Organism
Vitis vinifera (Grape)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg2+ or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei147SubstrateUniRule annotation1
Binding sitei152NADPUniRule annotation1
Binding sitei179SubstrateUniRule annotation1
Binding sitei202SubstrateUniRule annotation1
Sitei209Critical for catalysisUniRule annotation1
Sitei281Critical for catalysisUniRule annotation1
Metal bindingi321Magnesium or manganeseUniRule annotation1
Binding sitei329NADPUniRule annotation1
Metal bindingi344Magnesium or manganeseUniRule annotation1
Binding sitei397NADP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi145 – 147NADPUniRule annotation3
Nucleotide bindingi379 – 384NADPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:VIT_14s0066g00950Imported
OrganismiVitis vinifera (Grape)Imported
Taxonomic identifieri29760 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsVitalesVitaceaeVitis
Proteomesi
  • UP000009183 Componenti: Chromosome 14

PTM / Processingi

Proteomic databases

PRIDEiF6HUY0.

Interactioni

Protein-protein interaction databases

STRINGi29760.VIT_14s0066g00950.t01.

Structurei

3D structure databases

ProteinModelPortaliF6HUY0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini79 – 469Iso_dhInterPro annotationAdd BLAST391

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni164 – 170Substrate bindingUniRule annotation7

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1526. Eukaryota.
COG0538. LUCA.
InParanoidiF6HUY0.
KOiK00031.
OrthoDBiEOG09360AQU.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
SMARTiSM01329. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F6HUY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRVLRPKLR FGAMSGAAIF PSSSSLALKN PNLSISSDQR FFNGILFKNG
60 70 80 90 100
SILHDRFPNA SLRCFASAAT FDRVRVQNPI VEMDGDEMAR IMWRMIKDKL
110 120 130 140 150
IFPYLDLDIR YFDLGILNRD ATDDKVTVES AEATLKYNVA VKCATITPDE
160 170 180 190 200
ARVKEFGLKS MWRSPNGTIR NILNGTVFRE PILCQNVPRI VPGWKKPICI
210 220 230 240 250
GRHAFGDQYR ATDTVVEGPG KLKLVFAPEN GDPPVELNVY DFKGPGIALA
260 270 280 290 300
MYNVDESIRA FAESSMSLAF AKKWPLYLST KNTILKKYDG RFKDIFQDVY
310 320 330 340 350
EENWKQKFEE HSIWYEHRLI DDMVAYALKS DGGYVWACKN YDGDVQSDLL
360 370 380 390 400
AQGFGSLGLM TSVLLSSDGK TLEAEAAHGT VTRHFRQYQK GLETSTNSIA
410 420 430 440 450
SIFAWTRGLE HRAKLDKNER LLDFVHKLEA ACIETVESGN MTKDLAILIH
460 470 480
GPKASKEFYL NTEEFIDTVA HNLEAKQFCN QIHSYS
Length:486
Mass (Da):54,938
Last modified:July 27, 2011 - v1
Checksum:i173600B93C85B3D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN596252 Genomic DNA. Translation: CCB58498.1.
RefSeqiXP_002276200.2. XM_002276164.3.

Genome annotation databases

EnsemblPlantsiVIT_14s0066g00950.t01; VIT_14s0066g00950.t01; VIT_14s0066g00950.
GeneIDi100249290.
GrameneiVIT_14s0066g00950.t01; VIT_14s0066g00950.t01; VIT_14s0066g00950.
KEGGivvi:100249290.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN596252 Genomic DNA. Translation: CCB58498.1.
RefSeqiXP_002276200.2. XM_002276164.3.

3D structure databases

ProteinModelPortaliF6HUY0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi29760.VIT_14s0066g00950.t01.

Proteomic databases

PRIDEiF6HUY0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiVIT_14s0066g00950.t01; VIT_14s0066g00950.t01; VIT_14s0066g00950.
GeneIDi100249290.
GrameneiVIT_14s0066g00950.t01; VIT_14s0066g00950.t01; VIT_14s0066g00950.
KEGGivvi:100249290.

Phylogenomic databases

eggNOGiKOG1526. Eukaryota.
COG0538. LUCA.
InParanoidiF6HUY0.
KOiK00031.
OrthoDBiEOG09360AQU.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
SMARTiSM01329. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF6HUY0_VITVI
AccessioniPrimary (citable) accession number: F6HUY0
Entry historyi
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.