Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

F6HUY0 (F6HUY0_VITVI) Unreviewed, UniProtKB/TrEMBL

Last modified March 19, 2014. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] PIRNR PIRNR000108

EC=1.1.1.42 PIRNR PIRNR000108
Gene names
Ordered Locus Names:VIT_14s0066g00950 EMBL CCB58498.1
OrganismVitis vinifera (Grape) [Reference proteome]
Taxonomic identifier29760 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsVitalesVitaceaeVitis

Protein attributes

Sequence length486 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRSR PIRSR000108-3 PIRNR PIRNR000108

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding145 – 1473NADP By similarity PIRSR PIRSR000108-4
Nucleotide binding379 – 3846NADP By similarity PIRSR PIRSR000108-4
Region164 – 1707Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding3211Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding3441Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site1471Substrate By similarity PIRSR PIRSR000108-2
Binding site1521NADP By similarity PIRSR PIRSR000108-4
Binding site1791Substrate By similarity PIRSR PIRSR000108-2
Binding site2021Substrate By similarity PIRSR PIRSR000108-2
Binding site3291NADP By similarity PIRSR PIRSR000108-4
Binding site3971NADP; via amide nitrogen and carbonyl oxygen By similarity PIRSR PIRSR000108-4
Site2091Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2811Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
F6HUY0 [UniParc].

Last modified July 27, 2011. Version 1.
Checksum: 173600B93C85B3D3

FASTA48654,938
        10         20         30         40         50         60 
MLRVLRPKLR FGAMSGAAIF PSSSSLALKN PNLSISSDQR FFNGILFKNG SILHDRFPNA 

        70         80         90        100        110        120 
SLRCFASAAT FDRVRVQNPI VEMDGDEMAR IMWRMIKDKL IFPYLDLDIR YFDLGILNRD 

       130        140        150        160        170        180 
ATDDKVTVES AEATLKYNVA VKCATITPDE ARVKEFGLKS MWRSPNGTIR NILNGTVFRE 

       190        200        210        220        230        240 
PILCQNVPRI VPGWKKPICI GRHAFGDQYR ATDTVVEGPG KLKLVFAPEN GDPPVELNVY 

       250        260        270        280        290        300 
DFKGPGIALA MYNVDESIRA FAESSMSLAF AKKWPLYLST KNTILKKYDG RFKDIFQDVY 

       310        320        330        340        350        360 
EENWKQKFEE HSIWYEHRLI DDMVAYALKS DGGYVWACKN YDGDVQSDLL AQGFGSLGLM 

       370        380        390        400        410        420 
TSVLLSSDGK TLEAEAAHGT VTRHFRQYQK GLETSTNSIA SIFAWTRGLE HRAKLDKNER 

       430        440        450        460        470        480 
LLDFVHKLEA ACIETVESGN MTKDLAILIH GPKASKEFYL NTEEFIDTVA HNLEAKQFCN 


QIHSYS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FN596252 Genomic DNA. Translation: CCB58498.1.
RefSeqXP_002276200.2. XM_002276164.2.
UniGeneVvi.1079.

3D structure databases

ProteinModelPortalF6HUY0.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsVIT_14s0066g00950.t01; VIT_14s0066g00950.t01; VIT_14s0066g00950.
GeneID100249290.
KEGGvvi:100249290.

Phylogenomic databases

KOK00031.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF6HUY0_VITVI
AccessionPrimary (citable) accession number: F6HUY0
Entry history
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: March 19, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)