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F6HUY0

- F6HUY0_VITVI

UniProt

F6HUY0 - F6HUY0_VITVI

Protein

Isocitrate dehydrogenase [NADP]

Gene

VIT_14s0066g00950

Organism
Vitis vinifera (Grape)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 24 (01 Oct 2014)
      Sequence version 1 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei147 – 1471SubstrateUniRule annotation
    Binding sitei152 – 1521NADP
    Binding sitei179 – 1791SubstrateUniRule annotation
    Binding sitei202 – 2021SubstrateUniRule annotation
    Sitei209 – 2091Critical for catalysisUniRule annotation
    Sitei281 – 2811Critical for catalysisUniRule annotation
    Metal bindingi321 – 3211Magnesium or manganeseUniRule annotation
    Binding sitei329 – 3291NADP
    Metal bindingi344 – 3441Magnesium or manganeseUniRule annotation
    Binding sitei397 – 3971NADP; via amide nitrogen and carbonyl oxygen

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi145 – 1473NADP
    Nucleotide bindingi379 – 3846NADP

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:VIT_14s0066g00950Imported
    OrganismiVitis vinifera (Grape)Imported
    Taxonomic identifieri29760 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsVitalesVitaceaeVitis
    ProteomesiUP000009183: Chromosome 14

    Subcellular locationi

    GO - Cellular componenti

    1. chloroplast stroma Source: EnsemblPlants/Gramene
    2. chloroplast thylakoid Source: EnsemblPlants/Gramene

    Structurei

    3D structure databases

    ProteinModelPortaliF6HUY0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni164 – 1707Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    KOiK00031.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F6HUY0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRVLRPKLR FGAMSGAAIF PSSSSLALKN PNLSISSDQR FFNGILFKNG    50
    SILHDRFPNA SLRCFASAAT FDRVRVQNPI VEMDGDEMAR IMWRMIKDKL 100
    IFPYLDLDIR YFDLGILNRD ATDDKVTVES AEATLKYNVA VKCATITPDE 150
    ARVKEFGLKS MWRSPNGTIR NILNGTVFRE PILCQNVPRI VPGWKKPICI 200
    GRHAFGDQYR ATDTVVEGPG KLKLVFAPEN GDPPVELNVY DFKGPGIALA 250
    MYNVDESIRA FAESSMSLAF AKKWPLYLST KNTILKKYDG RFKDIFQDVY 300
    EENWKQKFEE HSIWYEHRLI DDMVAYALKS DGGYVWACKN YDGDVQSDLL 350
    AQGFGSLGLM TSVLLSSDGK TLEAEAAHGT VTRHFRQYQK GLETSTNSIA 400
    SIFAWTRGLE HRAKLDKNER LLDFVHKLEA ACIETVESGN MTKDLAILIH 450
    GPKASKEFYL NTEEFIDTVA HNLEAKQFCN QIHSYS 486
    Length:486
    Mass (Da):54,938
    Last modified:July 27, 2011 - v1
    Checksum:i173600B93C85B3D3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FN596252 Genomic DNA. Translation: CCB58498.1.
    RefSeqiXP_002276200.2. XM_002276164.2.
    UniGeneiVvi.1079.

    Genome annotation databases

    EnsemblPlantsiVIT_14s0066g00950.t01; VIT_14s0066g00950.t01; VIT_14s0066g00950.
    GeneIDi100249290.
    KEGGivvi:100249290.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FN596252 Genomic DNA. Translation: CCB58498.1 .
    RefSeqi XP_002276200.2. XM_002276164.2.
    UniGenei Vvi.1079.

    3D structure databases

    ProteinModelPortali F6HUY0.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi VIT_14s0066g00950.t01 ; VIT_14s0066g00950.t01 ; VIT_14s0066g00950 .
    GeneIDi 100249290.
    KEGGi vvi:100249290.

    Phylogenomic databases

    KOi K00031.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The grapevine genome sequence suggests ancestral hexaploidization in major angiosperm phyla."
      The French-Italian Public Consortium for Grapevine Genome Characterization.
      Jaillon O., Aury J.-M., Noel B., Policriti A., Clepet C., Casagrande A., Choisne N., Aubourg S., Vitulo N., Jubin C., Vezzi A., Legeai F., Hugueney P., Dasilva C., Horner D., Mica E., Jublot D., Poulain J.
      , Bruyere C., Billault A., Segurens B., Gouyvenoux M., Ugarte E., Cattonaro F., Anthouard V., Vico V., Del Fabbro C., Alaux M., Di Gaspero G., Dumas V., Felice N., Paillard S., Juman I., Moroldo M., Scalabrin S., Canaguier A., Le Clainche I., Malacrida G., Durand E., Pesole G., Laucou V., Chatelet P., Merdinoglu D., Delledonne M., Pezzotti M., Lecharny A., Scarpelli C., Artiguenave F., Pe M.E., Valle G., Morgante M., Caboche M., Adam-Blondon A.-F., Weissenbach J., Quetier F., Wincker P.
      Nature 449:463-467(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Pinot noir / PN40024Imported.

    Entry informationi

    Entry nameiF6HUY0_VITVI
    AccessioniPrimary (citable) accession number: F6HUY0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 27, 2011
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 24 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3