ID   F6GJJ6_LACS5            Unreviewed;       529 AA.
AC   F6GJJ6;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   27-MAR-2024, entry version 53.
DE   RecName: Full=DNA ligase (ATP) {ECO:0000256|ARBA:ARBA00012727};
DE            EC=6.5.1.1 {ECO:0000256|ARBA:ARBA00012727};
GN   OrderedLocusNames=Lacal_2600 {ECO:0000313|EMBL:AEH02441.1};
OS   Lacinutrix sp. (strain 5H-3-7-4).
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Lacinutrix.
OX   NCBI_TaxID=983544 {ECO:0000313|EMBL:AEH02441.1, ECO:0000313|Proteomes:UP000008297};
RN   [1] {ECO:0000313|EMBL:AEH02441.1, ECO:0000313|Proteomes:UP000008297}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=5H-3-7-4 {ECO:0000313|EMBL:AEH02441.1,
RC   ECO:0000313|Proteomes:UP000008297};
RX   PubMed=21725025; DOI=10.1128/JB.05518-11;
RA   Klippel B., Lochner A., Bruce D.C., Walston Davenport K., Detter C.,
RA   Goodwin L.A., Han J., Han S., Hauser L., Land M.L., Nolan M.,
RA   Ovchinnikova G., Pennacchio L., Pitluck S., Tapia R., Woyke T.,
RA   Wiebusch S., Basner A., Abe F., Horikoshi K., Keller M., Antranikian G.;
RT   "Complete genome sequences of Krokinobacter sp. strain 4H-3-7-5 and
RT   Lacinutrix sp. strain 5H-3-7-4, polysaccharide-degrading members of the
RT   family Flavobacteriaceae.";
RL   J. Bacteriol. 193:4545-4546(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC         (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP +
CC         diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003};
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DR   EMBL; CP002825; AEH02441.1; -; Genomic_DNA.
DR   RefSeq; WP_013871220.1; NC_015638.1.
DR   AlphaFoldDB; F6GJJ6; -.
DR   STRING; 983544.Lacal_2600; -.
DR   KEGG; lan:Lacal_2600; -.
DR   eggNOG; COG1793; Bacteria.
DR   HOGENOM; CLU_005138_6_2_10; -.
DR   OrthoDB; 9767858at2; -.
DR   Proteomes; UP000008297; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd07897; Adenylation_DNA_ligase_Bac1; 1.
DR   CDD; cd07972; OBF_DNA_ligase_Arch_LigB; 1.
DR   Gene3D; 1.10.3260.10; DNA ligase, ATP-dependent, N-terminal domain; 1.
DR   Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   InterPro; IPR026333; ATP_dep_DNA_lig_pp_1105_fam.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   NCBIfam; TIGR04120; DNA_lig_bact; 1.
DR   PANTHER; PTHR45674; DNA LIGASE 1/3 FAMILY MEMBER; 1.
DR   PANTHER; PTHR45674:SF13; DNA LIGASE-RELATED; 1.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   SUPFAM; SSF117018; ATP-dependent DNA ligase DNA-binding domain; 1.
DR   SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:AEH02441.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008297}.
FT   DOMAIN          303..434
FT                   /note="ATP-dependent DNA ligase family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50160"
SQ   SEQUENCE   529 AA;  61072 MW;  03AB2A342576B2F1 CRC64;
     MKHFSNLISA LEITNKTNAK IEALVNYFKT APEKDKLWLI SIFTGKRPPR PVKSSLMKQW
     AFEITKLPEW LFLESYSTVG DLGETIALIL PNPTHTIEKP LHQWMQELIA LKPKTEEEKK
     KYVLNAWSGL EKQERLIFNK LIGGSFRIGV SKKTLVNALS KLSGIDANQL MHSIIGNWNI
     ETINFSDLLN GSHINYDNSK PYPFCLAYAL EKDLLALGKP EDWQVEYKWD GIRGQIVKRN
     NEVYIWSRGE ELVTSQFPEI VETITNFKDD FVIDGEILAL KDSTVLLFND LQKRLNRKNI
     TKKLLEDIPV GFYAYDLLEY NNQDFRDKPM QERRNQLETL FSTVVINDKL KLSKIINFKN
     WEVLKEIREN ARTINSEGLM LKQKASPYHV GRKKGDWWKW KVEPLTIDAV MIYAQKGSGR
     RSSKYTDYTF AVKKDDGLVT VAKAYSGLTD AEITEISKWV NKNALEKFGP VRTVKPELVF
     EIAFEGIAYS KRHKSGVALR FPRIKRWRKD KPVSEIDTIE SVTALIEAQ
//