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F6GHT5 (F6GHT5_LACS5) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 13. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
ATP phosphoribosyltransferase HAMAP-Rule MF_00079
Short name=ATP-PRT HAMAP-Rule MF_00079
Short name=ATP-PRTase HAMAP-Rule MF_00079
EC=2.4.2.17 HAMAP-Rule MF_00079
Gene names
Name:hisG HAMAP-Rule MF_00079
Ordered Locus Names:Lacal_2429
OrganismLacinutrix sp. (strain 5H-3-7-4) [Complete proteome] [HAMAP] EMBL AEH02271.1
Taxonomic identifier983544 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Flavobacteriia › Flavobacteriales › Flavobacteriaceae › Lacinutrix

Protein attributes

Sequence length285 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity By similarity. HAMAP-Rule MF_00079

Catalytic activity

1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_00079 SAAS SAAS018198

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00079

Enzyme regulation

Feedback inhibited by histidine By similarity. HAMAP-Rule MF_00079

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9. HAMAP-Rule MF_00079 SAAS SAAS018198

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00079.

Sequence similarities

Belongs to the ATP phosphoribosyltransferase family. Long subfamily. HAMAP-Rule MF_00079

Sequences

Sequence LengthMass (Da)Tools
F6GHT5 [UniParc].

Last modified July 27, 2011. Version 1.
Checksum: 1C2E3827878131E3

FASTA28531,017
        10         20         30         40         50         60 
MSKLKIAVQK SGRLNEDSMK ILKAVGISID NGKDQLKASA KNFPLEIFYL RNGDIPQYLK 

        70         80         90        100        110        120 
DGVVDVAIIG ENVLIEKGND IKIAEKLGFS SCKVSVAVPK AATYNSVKDL EGKRIATSYP 

       130        140        150        160        170        180 
NTVNQFLNKN GIKANLHIIN GSVEIAPNIG LADAIVDIVS SGSTLFKNGL KEAEVILKSE 

       190        200        210        220        230        240 
AVLAVSPKIS EDNQAILNKL QFRLQSVLKA RQSRYVLLNA PNNKVNDIIN ILPGMKSPTV 

       250        260        270        280 
LPLAEDGWSS IHSVINKNDF WEIIDELKEN GAEGILVCPI ENMVI

« Hide

References

[1]"Complete genome sequences of Krokinobacter sp. strain 4H-3-7-5 and Lacinutrix sp. strain 5H-3-7-4, polysaccharide-degrading members of the family Flavobacteriaceae."
Klippel B., Lochner A., Bruce D.C., Walston Davenport K., Detter C., Goodwin L.A., Han J., Han S., Hauser L., Land M.L., Nolan M., Ovchinnikova G., Pennacchio L., Pitluck S., Tapia R., Woyke T., Wiebusch S., Basner A. expand/collapse author list , Abe F., Horikoshi K., Keller M., Antranikian G.
J. Bacteriol. 193:4545-4546(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 5H-3-7-4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002825 Genomic DNA. Translation: AEH02271.1.
RefSeqYP_004580699.1. NC_015638.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEH02271; AEH02271; Lacal_2429.
GeneID10780098.
KEGGlan:Lacal_2429.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK00765.

Enzyme and pathway databases

BioCycLSP983544:GHSZ-2469-MONOMER.
UniPathwayUPA00031; UER00006.

Family and domain databases

Gene3D3.30.70.120. 1 hit.
HAMAPMF_00079. HisG_Long.
InterProIPR013820. ATP_PRibTrfase_cat.
IPR018198. ATP_PRibTrfase_CS.
IPR001348. ATP_PRibTrfase_HisG.
IPR020621. ATP_PRibTrfase_HisG_long.
IPR013115. HisG_C.
IPR011322. N-reg_PII-like_a/b.
IPR015867. N-reg_PII/ATP_PRibTrfase_C.
[Graphical view]
PANTHERPTHR21403. PTHR21403. 1 hit.
PfamPF01634. HisG. 1 hit.
PF08029. HisG_C. 1 hit.
[Graphical view]
SUPFAMSSF54913. N-reg_PII-like_a/b. 1 hit.
TIGRFAMsTIGR00070. hisG. 1 hit.
TIGR03455. HisG_C-term. 1 hit.
PROSITEPS01316. ATP_P_PHORIBOSYLTR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF6GHT5_LACS5
AccessionPrimary (citable) accession number: F6GHT5
Entry history
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: April 3, 2013
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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