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F6G4U4

- F6G4U4_RALS8

UniProt

F6G4U4 - F6G4U4_RALS8

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Protein
Kynureninase
Gene
kynU, RSPO_c02606
Organism
Ralstonia solanacearum (strain Po82)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei98 – 981Pyridoxal phosphate; via amide nitrogen By similarityUniRule annotation
Binding sitei99 – 991Pyridoxal phosphate By similarityUniRule annotation
Binding sitei173 – 1731Pyridoxal phosphate By similarityUniRule annotation
Binding sitei202 – 2021Pyridoxal phosphate By similarityUniRule annotation
Binding sitei205 – 2051Pyridoxal phosphate By similarityUniRule annotation
Binding sitei227 – 2271Pyridoxal phosphate By similarityUniRule annotation
Binding sitei257 – 2571Pyridoxal phosphate By similarityUniRule annotation
Binding sitei283 – 2831Pyridoxal phosphate By similarityUniRule annotation

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  3. anthranilate metabolic process Source: UniProtKB-HAMAP
  4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  5. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciRSOL1031711:GLJ5-2650-MONOMER.
UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
L-kynurenine hydrolase
Gene namesi
Name:kynUUniRule annotationImported
Ordered Locus Names:RSPO_c02606Imported
OrganismiRalstonia solanacearum (strain Po82)Imported
Taxonomic identifieri1031711 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
ProteomesiUP000007953: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei228 – 2281N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni130 – 1334Pyridoxal phosphate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK01556.
OMAiVWDLAHS.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

F6G4U4-1 [UniParc]FASTAAdd to Basket

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MTLTRNTCLE RDAADPIAPL RDAFALPDGV IYLDGNSLGA RPRAALARAQ    50
QVVADEWGEG LIRSWNQSGW FDLPRRLGNK LAPLIGARPD EVVVTDTTSI 100
NLFKVLAAAL RVQREDAPER KIIVSETHNF PTDLYIAEGL ADLLRDGYKL 150
RLIDAPDELE AALGDDVAVT MLTHVNYKSG HMYDMAAVSA LAHRHGALAV 200
WDLAHSAGAV PVDLHAGGAD YAIGCTYKYL NGGPGSPAFV WVSPALRERF 250
WQPLSGWWGH ARPFAMESRY DAGAGIGRFL CGTQPITSMA MVECGLDLFA 300
QTSMAALRAK SLALTDLFIE LIETRCAGYP LTLATPRDHA VRGSHVSYAH 350
PDGFAVMQAL IARGVIGDYR EPHIMRFGFT PLYTRFVDVW DAVEVLRDVL 400
ETGAWQSAQF NERTLVT 417
Length:417
Mass (Da):45,660
Last modified:July 27, 2011 - v1
Checksum:i20D59ACD45B2C434
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002819 Genomic DNA. Translation: AEG69899.1.
RefSeqiYP_006030435.1. NC_017574.1.

Genome annotation databases

EnsemblBacteriaiAEG69899; AEG69899; RSPO_c02606.
GeneIDi12626708.
KEGGirsn:RSPO_c02606.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002819 Genomic DNA. Translation: AEG69899.1 .
RefSeqi YP_006030435.1. NC_017574.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEG69899 ; AEG69899 ; RSPO_c02606 .
GeneIDi 12626708.
KEGGi rsn:RSPO_c02606.

Phylogenomic databases

KOi K01556.
OMAi VWDLAHS.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00329 .
UPA00334 ; UER00455 .
BioCyci RSOL1031711:GLJ5-2650-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01970. Kynureninase.
InterProi IPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR14084. PTHR14084. 1 hit.
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF038800. KYNU. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01814. kynureninase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the plant pathogen Ralstonia solanacearum strain Po82."
    Xu J., Zheng H.J., Liu L., Pan Z.C., Prior P., Tang B., Xu J.S., Zhang H., Tian Q., Zhang L.Q., Feng J.
    J. Bacteriol. 193:4261-4262(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Po82Imported.

Entry informationi

Entry nameiF6G4U4_RALS8
AccessioniPrimary (citable) accession number: F6G4U4
Entry historyi
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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