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F6G4U4

- F6G4U4_RALS8

UniProt

F6G4U4 - F6G4U4_RALS8

Protein

Kynureninase

Gene

kynU

Organism
Ralstonia solanacearum (strain Po82)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 20 (01 Oct 2014)
      Sequence version 1 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

    Catalytic activityi

    L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
    L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei98 – 981Pyridoxal phosphate; via amide nitrogenUniRule annotation
    Binding sitei99 – 991Pyridoxal phosphateUniRule annotation
    Binding sitei173 – 1731Pyridoxal phosphateUniRule annotation
    Binding sitei202 – 2021Pyridoxal phosphateUniRule annotation
    Binding sitei205 – 2051Pyridoxal phosphateUniRule annotation
    Binding sitei227 – 2271Pyridoxal phosphateUniRule annotation
    Binding sitei257 – 2571Pyridoxal phosphateUniRule annotation
    Binding sitei283 – 2831Pyridoxal phosphateUniRule annotation

    GO - Molecular functioni

    1. kynureninase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
    2. anthranilate metabolic process Source: UniProtKB-HAMAP
    3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
    4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
    5. tryptophan catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    HydrolaseUniRule annotation

    Keywords - Biological processi

    Pyridine nucleotide biosynthesisUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    BioCyciRSOL1031711:GLJ5-2650-MONOMER.
    UniPathwayiUPA00253; UER00329.
    UPA00334; UER00455.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
    Alternative name(s):
    L-kynurenine hydrolaseUniRule annotation
    Gene namesi
    Name:kynUUniRule annotationImported
    Ordered Locus Names:RSPO_c02606Imported
    OrganismiRalstonia solanacearum (strain Po82)Imported
    Taxonomic identifieri1031711 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
    ProteomesiUP000007953: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei228 – 2281N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni130 – 1334Pyridoxal phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the kynureninase family.UniRule annotation

    Phylogenomic databases

    KOiK01556.
    OMAiVWDLAHS.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_01970. Kynureninase.
    InterProiIPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR14084. PTHR14084. 1 hit.
    PfamiPF00266. Aminotran_5. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038800. KYNU. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01814. kynureninase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    F6G4U4-1 [UniParc]FASTAAdd to Basket

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    MTLTRNTCLE RDAADPIAPL RDAFALPDGV IYLDGNSLGA RPRAALARAQ    50
    QVVADEWGEG LIRSWNQSGW FDLPRRLGNK LAPLIGARPD EVVVTDTTSI 100
    NLFKVLAAAL RVQREDAPER KIIVSETHNF PTDLYIAEGL ADLLRDGYKL 150
    RLIDAPDELE AALGDDVAVT MLTHVNYKSG HMYDMAAVSA LAHRHGALAV 200
    WDLAHSAGAV PVDLHAGGAD YAIGCTYKYL NGGPGSPAFV WVSPALRERF 250
    WQPLSGWWGH ARPFAMESRY DAGAGIGRFL CGTQPITSMA MVECGLDLFA 300
    QTSMAALRAK SLALTDLFIE LIETRCAGYP LTLATPRDHA VRGSHVSYAH 350
    PDGFAVMQAL IARGVIGDYR EPHIMRFGFT PLYTRFVDVW DAVEVLRDVL 400
    ETGAWQSAQF NERTLVT 417
    Length:417
    Mass (Da):45,660
    Last modified:July 27, 2011 - v1
    Checksum:i20D59ACD45B2C434
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002819 Genomic DNA. Translation: AEG69899.1.
    RefSeqiYP_006030435.1. NC_017574.1.

    Genome annotation databases

    EnsemblBacteriaiAEG69899; AEG69899; RSPO_c02606.
    GeneIDi12626708.
    KEGGirsn:RSPO_c02606.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002819 Genomic DNA. Translation: AEG69899.1 .
    RefSeqi YP_006030435.1. NC_017574.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEG69899 ; AEG69899 ; RSPO_c02606 .
    GeneIDi 12626708.
    KEGGi rsn:RSPO_c02606.

    Phylogenomic databases

    KOi K01556.
    OMAi VWDLAHS.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00329 .
    UPA00334 ; UER00455 .
    BioCyci RSOL1031711:GLJ5-2650-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_01970. Kynureninase.
    InterProi IPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR14084. PTHR14084. 1 hit.
    Pfami PF00266. Aminotran_5. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038800. KYNU. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01814. kynureninase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the plant pathogen Ralstonia solanacearum strain Po82."
      Xu J., Zheng H.J., Liu L., Pan Z.C., Prior P., Tang B., Xu J.S., Zhang H., Tian Q., Zhang L.Q., Feng J.
      J. Bacteriol. 193:4261-4262(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Po82Imported.

    Entry informationi

    Entry nameiF6G4U4_RALS8
    AccessioniPrimary (citable) accession number: F6G4U4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 27, 2011
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3