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F6FWS0

- F6FWS0_ISOV2

UniProt

F6FWS0 - F6FWS0_ISOV2

Protein

Alanine racemase

Gene

Isova_0706

Organism
Isoptericola variabilis (strain 225)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 24 (01 Oct 2014)
      Sequence version 1 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei48 – 481Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei148 – 1481SubstrateUniRule annotation
    Active sitei282 – 2821Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei339 – 3391Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciIVAR743718:GI39-718-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:Isova_0706Imported
    OrganismiIsoptericola variabilis (strain 225)Imported
    Taxonomic identifieri743718 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaePromicromonosporaceaeIsoptericola
    ProteomesiUP000009236: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei48 – 481N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliF6FWS0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    KOiK01775.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F6FWS0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRESLTVSSS DLAPGAPARA VVDLDAIRDN VRALRDHAPS SDLMAVVKAD    50
    GYGHGMVPAA RAALAGGATW LGVATAHEAL ALRASGVTGD ARVLVWLLVP 100
    GAPFADLVRA DVDVTVAAPW SVDEVAAGAR EAGRPARVHL KVDTGLSRNG 150
    VTPADLPGVV RRLATLEASG EVRVVGVFSH LACADEPGHP SVARQAAAFD 200
    DAARAVAAAG LRPEVRHLAN SAATLTAPEV HHDLVRPGIA VYGLSPVPQL 250
    GPPGAYGLRP AMTLEARLGN VKAVPAGEGV SYGHLYTTPR DTVLGLVPLG 300
    YADGIPRHAS GGSAGVGGPV AVGSGDARRV LRIAGRVCMD QVVLDLGPDA 350
    TERPGDVATL FGASEGVAHG ATVPNAQDWA EAAGTISYEI VTRIGARVPR 400
    TYAGKDVQP 409
    Length:409
    Mass (Da):41,655
    Last modified:July 27, 2011 - v1
    Checksum:iF0C19C775EAC85A9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002810 Genomic DNA. Translation: AEG43492.1.
    RefSeqiWP_013837884.1. NC_015588.1.
    YP_004541386.1. NC_015588.1.

    Genome annotation databases

    EnsemblBacteriaiAEG43492; AEG43492; Isova_0706.
    GeneIDi10732306.
    KEGGiiva:Isova_0706.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002810 Genomic DNA. Translation: AEG43492.1 .
    RefSeqi WP_013837884.1. NC_015588.1.
    YP_004541386.1. NC_015588.1.

    3D structure databases

    ProteinModelPortali F6FWS0.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEG43492 ; AEG43492 ; Isova_0706 .
    GeneIDi 10732306.
    KEGGi iva:Isova_0706.

    Phylogenomic databases

    KOi K01775.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci IVAR743718:GI39-718-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 225Imported.

    Entry informationi

    Entry nameiF6FWS0_ISOV2
    AccessioniPrimary (citable) accession number: F6FWS0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 27, 2011
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 24 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3