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F6FWS0

- F6FWS0_ISOV2

UniProt

F6FWS0 - F6FWS0_ISOV2

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Protein

Alanine racemase

Gene

Isova_0706

Organism
Isoptericola variabilis (strain 225)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Note: Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei48 – 481Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei148 – 1481SubstrateUniRule annotation
Active sitei282 – 2821Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei339 – 3391Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciIVAR743718:GI39-718-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Isova_0706Imported
OrganismiIsoptericola variabilis (strain 225)Imported
Taxonomic identifieri743718 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaePromicromonosporaceaeIsoptericola
ProteomesiUP000009236: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei48 – 481N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliF6FWS0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F6FWS0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRESLTVSSS DLAPGAPARA VVDLDAIRDN VRALRDHAPS SDLMAVVKAD
60 70 80 90 100
GYGHGMVPAA RAALAGGATW LGVATAHEAL ALRASGVTGD ARVLVWLLVP
110 120 130 140 150
GAPFADLVRA DVDVTVAAPW SVDEVAAGAR EAGRPARVHL KVDTGLSRNG
160 170 180 190 200
VTPADLPGVV RRLATLEASG EVRVVGVFSH LACADEPGHP SVARQAAAFD
210 220 230 240 250
DAARAVAAAG LRPEVRHLAN SAATLTAPEV HHDLVRPGIA VYGLSPVPQL
260 270 280 290 300
GPPGAYGLRP AMTLEARLGN VKAVPAGEGV SYGHLYTTPR DTVLGLVPLG
310 320 330 340 350
YADGIPRHAS GGSAGVGGPV AVGSGDARRV LRIAGRVCMD QVVLDLGPDA
360 370 380 390 400
TERPGDVATL FGASEGVAHG ATVPNAQDWA EAAGTISYEI VTRIGARVPR

TYAGKDVQP
Length:409
Mass (Da):41,655
Last modified:July 27, 2011 - v1
Checksum:iF0C19C775EAC85A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002810 Genomic DNA. Translation: AEG43492.1.
RefSeqiYP_004541386.1. NC_015588.1.

Genome annotation databases

EnsemblBacteriaiAEG43492; AEG43492; Isova_0706.
GeneIDi10732306.
KEGGiiva:Isova_0706.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002810 Genomic DNA. Translation: AEG43492.1 .
RefSeqi YP_004541386.1. NC_015588.1.

3D structure databases

ProteinModelPortali F6FWS0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEG43492 ; AEG43492 ; Isova_0706 .
GeneIDi 10732306.
KEGGi iva:Isova_0706.

Phylogenomic databases

KOi K01775.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci IVAR743718:GI39-718-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 225Imported.

Entry informationi

Entry nameiF6FWS0_ISOV2
AccessioniPrimary (citable) accession number: F6FWS0
Entry historyi
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3