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F6FWH1 (F6FWH1_ISOV2) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 13. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesSubmitted name:
Methionine synthase EMBL AEG44545.1
EC=2.1.1.13 EMBL AEG44545.1
Gene names
Ordered Locus Names:Isova_1799
OrganismIsoptericola variabilis (strain 225) [Complete proteome] [HAMAP]
Taxonomic identifier743718 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Promicromonosporaceae › Isoptericola ›

Protein attributes

Sequence length1191 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Cofactor

Binds 1 zinc ion per subunit By similarity. PIRSR PIRSR000381-1

Cobalamin By similarity. PIRSR PIRSR000381-2

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region832 – 8332Cobalamin-binding By similarity PIRSR PIRSR000381-2
Region1188 – 11892S-adenosyl-L-methionine binding By similarity PIRSR PIRSR000381-2

Sites

Metal binding2351Zinc By similarity PIRSR PIRSR000381-1
Metal binding3011Zinc By similarity PIRSR PIRSR000381-1
Metal binding3021Zinc By similarity PIRSR PIRSR000381-1
Metal binding7551Cobalt (cobalamin axial ligand) By similarity PIRSR PIRSR000381-1
Binding site9391S-adenosyl-L-methionine By similarity PIRSR PIRSR000381-2
Binding site11341S-adenosyl-L-methionine; via carbonyl oxygen By similarity PIRSR PIRSR000381-2
Binding site11381Cobalamin; via carbonyl oxygen By similarity PIRSR PIRSR000381-2

Sequences

Sequence LengthMass (Da)Tools
F6FWH1 [UniParc].

Last modified July 27, 2011. Version 1.
Checksum: 31D8F09AAB86D5A9

FASTA1,191129,576
        10         20         30         40         50         60 
MTSTLDVSAA DARADALLQA MRTRVVVADG AMGTMIQDAD PTLEDYEGHE GCNEVLNVSR 

        70         80         90        100        110        120 
PDIIRSVHDA YLEVGVDAIE TNTFGANWSN LSDYGIEDRI RELARAGAEL ARERADAWST 

       130        140        150        160        170        180 
PEHPRWVLGS MGPGTKLPSL GHTTYAHLKA TFAEQAAGLL EGGADAILVE TSQDLLQAKA 

       190        200        210        220        230        240 
AVNGAREAMA AVGRRVPVIV SVTVETTGTM LMGSEIGAAL TTLQALGVDA IGLNCATGPD 

       250        260        270        280        290        300 
QMSEHLRHLA RHSEVPVACM PNAGLPELGP KGAVYPLTAP ELATAHAQFV EEFSLGLVGG 

       310        320        330        340        350        360 
CCGTTPEHLR QVVEAVRGRE LTARPVEREN GVASLYSHTD LHQDASYLAI GERTNANGSK 

       370        380        390        400        410        420 
AFREAMLDGR WDDVVDIARA QTRDGAHLLD VCVDYVGRDG VADVREVVSR LASASTLPLV 

       430        440        450        460        470        480 
IDSTEPEVIK AGLELVGGRA VVNSVNFEDG DGPTSRFARI MPLVKEHGAA VIALTIDEEG 

       490        500        510        520        530        540 
QARTAEKKVA IASRLIDTLT GDWGMRVDDI IVDALTFPIA TGQEETRRDA IETIEAIREI 

       550        560        570        580        590        600 
TRRYPGVHTT LGVSNVSFGL NPAARTVLNS VFLHEAVQAG LDSAIVHAAK ILPRTAIPDE 

       610        620        630        640        650        660 
QWEAAEDLVR DRRRYDDEGN LVHDPLSHLL ELFSGVDSAS LRDQRAAELA ALPVGERLER 

       670        680        690        700        710        720 
RIIDGARKGL EDDVEEALAL GMKALDIVNT HLLGGMKVVG ELFGSGQMQL PFVLQSAEVM 

       730        740        750        760        770        780 
KAAVALLEPH MERVAGGPDE TKGTIVLATV RGDVHDIGKN LVDIILTNNG YKVVNIGIKQ 

       790        800        810        820        830        840 
PISAMIEAAE QHDADVIGMS GLLVKSTVVM KENLEELVSR GLEKKWPILL GGAALTRTYV 

       850        860        870        880        890        900 
EDDLASMFPG TVRYARDAFE GLRLMEPLVR IARGASPDDV GLPPLRKRRH DVVKVTETAP 

       910        920        930        940        950        960 
EELPARSDVA TDNPVPTPPF WGTRIVKGVQ LADYAAFLDE RATFMGQWGL KPGRGDDGAS 

       970        980        990       1000       1010       1020 
YEELVETEGR PRLAEWLERI RTESILDPTV VYGYFPVWSE GNDLVVGHHE GPDGGSGGPV 

      1030       1040       1050       1060       1070       1080 
GTERLRFRFP RQRRDRHLCL ADFVKPRSWA EETGRFDVLP VQLVTVGDSV SQHTARLFEA 

      1090       1100       1110       1120       1130       1140 
NRYREYMELH GLSVQLTEAL AEFWHARVRD ELGFADEDPS DVEGMFKLAY RGARFSLGYP 

      1150       1160       1170       1180       1190 
ACPDMEDRRK VVELLRPERV GVVLSDELQL HPEQSTDAFV FHHPEAKYFS V

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References

[1]"Complete sequence of Isoptericola variabilis 225."
US DOE Joint Genome Institute
Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Mikhailova N., Zeytun A., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Siebers A., Allgaier M. expand/collapse author list , Thelen M., Hugenholtz P., Gladden J., Woyke T.
Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 225.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002810 Genomic DNA. Translation: AEG44545.1.
RefSeqYP_004542439.1. NC_015588.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEG44545; AEG44545; Isova_1799.
GeneID10733420.
KEGGiva:Isova_1799.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK00548.

Enzyme and pathway databases

BioCycIVAR743718:GI39-1832-MONOMER.

Family and domain databases

Gene3D1.10.1240.10. 1 hit.
3.10.196.10. 1 hit.
3.20.20.20. 1 hit.
3.20.20.330. 1 hit.
3.40.50.280. 1 hit.
InterProIPR003759. Cbl-bd_cap.
IPR006158. Cobalamin-bd.
IPR011005. Dihydropteroate_synth-like.
IPR011822. MetH.
IPR000489. Pterin-binding.
IPR003726. S_MeTrfase.
IPR004223. VitB12-dep_Met_synth_activ_dom.
[Graphical view]
PfamPF02310. B12-binding. 1 hit.
PF02607. B12-binding_2. 1 hit.
PF02965. Met_synt_B12. 1 hit.
PF00809. Pterin_bind. 1 hit.
PF02574. S-methyl_trans. 1 hit.
[Graphical view]
PIRSFPIRSF000381. MetH. 1 hit.
SMARTSM01018. B12-binding_2. 1 hit.
[Graphical view]
SUPFAMSSF52242. Cbl-bd. 1 hit.
SSF51717. DHP_synth_like. 1 hit.
SSF56507. Met_synth_B12. 1 hit.
SSF47644. Met_synth_Cbl-bd. 1 hit.
SSF82282. S_methyl_trans. 1 hit.
TIGRFAMsTIGR02082. metH. 1 hit.
PROSITEPS50974. ADOMET_ACTIVATION. 1 hit.
PS51332. B12_BINDING. 1 hit.
PS51337. B12_BINDING_NTER. 1 hit.
PS50970. HCY. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF6FWH1_ISOV2
AccessionPrimary (citable) accession number: F6FWH1
Entry history
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: April 3, 2013
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info