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F6FWH1

- F6FWH1_ISOV2

UniProt

F6FWH1 - F6FWH1_ISOV2

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Protein
Submitted name:

Methionine synthase

Gene
Isova_1799
Organism
Isoptericola variabilis (strain 225)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation
Cobalamin By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi235 – 2351Zinc By similarityUniRule annotation
Metal bindingi301 – 3011Zinc By similarityUniRule annotation
Metal bindingi302 – 3021Zinc By similarityUniRule annotation
Metal bindingi755 – 7551Cobalt (cobalamin axial ligand) By similarityUniRule annotation
Binding sitei939 – 9391S-adenosyl-L-methionine By similarityUniRule annotation
Binding sitei1134 – 11341S-adenosyl-L-methionine; via carbonyl oxygen By similarityUniRule annotation
Binding sitei1138 – 11381Cobalamin; via carbonyl oxygen By similarityUniRule annotation

GO - Molecular functioni

  1. cobalamin binding Source: UniProtKB-KW
  2. methionine synthase activity Source: UniProtKB-EC
  3. S-adenosylmethionine-homocysteine S-methyltransferase activity Source: InterPro
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. pteridine-containing compound metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseImported, Transferase

Keywords - Ligandi

CobalaminUniRule annotation, Cobalt, Metal-bindingUniRule annotation, S-adenosyl-L-methionineUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

BioCyciIVAR743718:GI39-1832-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Methionine synthaseImported (EC:2.1.1.13Imported)
Gene namesi
Ordered Locus Names:Isova_1799Imported
OrganismiIsoptericola variabilis (strain 225)
Taxonomic identifieri743718 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaePromicromonosporaceaeIsoptericola
ProteomesiUP000009236: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni832 – 8332Cobalamin-binding By similarityUniRule annotation
Regioni1188 – 11892S-adenosyl-L-methionine binding By similarityUniRule annotation

Phylogenomic databases

KOiK00548.

Family and domain databases

Gene3Di1.10.1240.10. 1 hit.
3.10.196.10. 1 hit.
3.20.20.20. 1 hit.
3.20.20.330. 1 hit.
3.40.50.280. 1 hit.
InterProiIPR003759. Cbl-bd_cap.
IPR006158. Cobalamin-bd.
IPR011005. Dihydropteroate_synth-like.
IPR011822. MetH.
IPR000489. Pterin-binding.
IPR003726. S_MeTrfase.
IPR004223. VitB12-dep_Met_synth_activ_dom.
[Graphical view]
PfamiPF02310. B12-binding. 1 hit.
PF02607. B12-binding_2. 1 hit.
PF02965. Met_synt_B12. 1 hit.
PF00809. Pterin_bind. 1 hit.
PF02574. S-methyl_trans. 1 hit.
[Graphical view]
PIRSFiPIRSF000381. MetH. 1 hit.
SMARTiSM01018. B12-binding_2. 1 hit.
[Graphical view]
SUPFAMiSSF47644. SSF47644. 1 hit.
SSF51717. SSF51717. 1 hit.
SSF52242. SSF52242. 1 hit.
SSF56507. SSF56507. 1 hit.
SSF82282. SSF82282. 1 hit.
TIGRFAMsiTIGR02082. metH. 1 hit.
PROSITEiPS50974. ADOMET_ACTIVATION. 1 hit.
PS51332. B12_BINDING. 1 hit.
PS51337. B12_BINDING_NTER. 1 hit.
PS50970. HCY. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F6FWH1-1 [UniParc]FASTAAdd to Basket

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MTSTLDVSAA DARADALLQA MRTRVVVADG AMGTMIQDAD PTLEDYEGHE     50
GCNEVLNVSR PDIIRSVHDA YLEVGVDAIE TNTFGANWSN LSDYGIEDRI 100
RELARAGAEL ARERADAWST PEHPRWVLGS MGPGTKLPSL GHTTYAHLKA 150
TFAEQAAGLL EGGADAILVE TSQDLLQAKA AVNGAREAMA AVGRRVPVIV 200
SVTVETTGTM LMGSEIGAAL TTLQALGVDA IGLNCATGPD QMSEHLRHLA 250
RHSEVPVACM PNAGLPELGP KGAVYPLTAP ELATAHAQFV EEFSLGLVGG 300
CCGTTPEHLR QVVEAVRGRE LTARPVEREN GVASLYSHTD LHQDASYLAI 350
GERTNANGSK AFREAMLDGR WDDVVDIARA QTRDGAHLLD VCVDYVGRDG 400
VADVREVVSR LASASTLPLV IDSTEPEVIK AGLELVGGRA VVNSVNFEDG 450
DGPTSRFARI MPLVKEHGAA VIALTIDEEG QARTAEKKVA IASRLIDTLT 500
GDWGMRVDDI IVDALTFPIA TGQEETRRDA IETIEAIREI TRRYPGVHTT 550
LGVSNVSFGL NPAARTVLNS VFLHEAVQAG LDSAIVHAAK ILPRTAIPDE 600
QWEAAEDLVR DRRRYDDEGN LVHDPLSHLL ELFSGVDSAS LRDQRAAELA 650
ALPVGERLER RIIDGARKGL EDDVEEALAL GMKALDIVNT HLLGGMKVVG 700
ELFGSGQMQL PFVLQSAEVM KAAVALLEPH MERVAGGPDE TKGTIVLATV 750
RGDVHDIGKN LVDIILTNNG YKVVNIGIKQ PISAMIEAAE QHDADVIGMS 800
GLLVKSTVVM KENLEELVSR GLEKKWPILL GGAALTRTYV EDDLASMFPG 850
TVRYARDAFE GLRLMEPLVR IARGASPDDV GLPPLRKRRH DVVKVTETAP 900
EELPARSDVA TDNPVPTPPF WGTRIVKGVQ LADYAAFLDE RATFMGQWGL 950
KPGRGDDGAS YEELVETEGR PRLAEWLERI RTESILDPTV VYGYFPVWSE 1000
GNDLVVGHHE GPDGGSGGPV GTERLRFRFP RQRRDRHLCL ADFVKPRSWA 1050
EETGRFDVLP VQLVTVGDSV SQHTARLFEA NRYREYMELH GLSVQLTEAL 1100
AEFWHARVRD ELGFADEDPS DVEGMFKLAY RGARFSLGYP ACPDMEDRRK 1150
VVELLRPERV GVVLSDELQL HPEQSTDAFV FHHPEAKYFS V 1191
Length:1,191
Mass (Da):129,576
Last modified:July 27, 2011 - v1
Checksum:i31D8F09AAB86D5A9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002810 Genomic DNA. Translation: AEG44545.1.
RefSeqiYP_004542439.1. NC_015588.1.

Genome annotation databases

EnsemblBacteriaiAEG44545; AEG44545; Isova_1799.
GeneIDi10733420.
KEGGiiva:Isova_1799.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002810 Genomic DNA. Translation: AEG44545.1 .
RefSeqi YP_004542439.1. NC_015588.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEG44545 ; AEG44545 ; Isova_1799 .
GeneIDi 10733420.
KEGGi iva:Isova_1799.

Phylogenomic databases

KOi K00548.

Enzyme and pathway databases

BioCyci IVAR743718:GI39-1832-MONOMER.

Family and domain databases

Gene3Di 1.10.1240.10. 1 hit.
3.10.196.10. 1 hit.
3.20.20.20. 1 hit.
3.20.20.330. 1 hit.
3.40.50.280. 1 hit.
InterProi IPR003759. Cbl-bd_cap.
IPR006158. Cobalamin-bd.
IPR011005. Dihydropteroate_synth-like.
IPR011822. MetH.
IPR000489. Pterin-binding.
IPR003726. S_MeTrfase.
IPR004223. VitB12-dep_Met_synth_activ_dom.
[Graphical view ]
Pfami PF02310. B12-binding. 1 hit.
PF02607. B12-binding_2. 1 hit.
PF02965. Met_synt_B12. 1 hit.
PF00809. Pterin_bind. 1 hit.
PF02574. S-methyl_trans. 1 hit.
[Graphical view ]
PIRSFi PIRSF000381. MetH. 1 hit.
SMARTi SM01018. B12-binding_2. 1 hit.
[Graphical view ]
SUPFAMi SSF47644. SSF47644. 1 hit.
SSF51717. SSF51717. 1 hit.
SSF52242. SSF52242. 1 hit.
SSF56507. SSF56507. 1 hit.
SSF82282. SSF82282. 1 hit.
TIGRFAMsi TIGR02082. metH. 1 hit.
PROSITEi PS50974. ADOMET_ACTIVATION. 1 hit.
PS51332. B12_BINDING. 1 hit.
PS51337. B12_BINDING_NTER. 1 hit.
PS50970. HCY. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 225.

Entry informationi

Entry nameiF6FWH1_ISOV2
AccessioniPrimary (citable) accession number: F6FWH1
Entry historyi
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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