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F6FWH1

- F6FWH1_ISOV2

UniProt

F6FWH1 - F6FWH1_ISOV2

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Protein
Submitted name:

Methionine synthase

Gene

Isova_1799

Organism
Isoptericola variabilis (strain 225)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi

Functioni

Cofactori

Protein has several cofactor binding sites:
  • Note: Binds 1 zinc ion per subunit.UniRule annotation
  • Note: Cobalamin.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi235 – 2351ZincUniRule annotation
Metal bindingi301 – 3011ZincUniRule annotation
Metal bindingi302 – 3021ZincUniRule annotation
Metal bindingi755 – 7551Cobalt (cobalamin axial ligand)UniRule annotation

GO - Molecular functioni

  1. cobalamin binding Source: UniProtKB-KW
  2. methionine synthase activity Source: UniProtKB-EC
  3. S-adenosylmethionine-homocysteine S-methyltransferase activity Source: InterPro
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. pteridine-containing compound metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseImported, Transferase

Keywords - Ligandi

CobalaminUniRule annotation, Cobalt, Metal-bindingUniRule annotation, S-adenosyl-L-methionineUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

BioCyciIVAR743718:GI39-1832-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Methionine synthaseImported (EC:2.1.1.13Imported)
Gene namesi
Ordered Locus Names:Isova_1799Imported
OrganismiIsoptericola variabilis (strain 225)Imported
Taxonomic identifieri743718 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaePromicromonosporaceaeIsoptericola
ProteomesiUP000009236: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

Family & Domainsi

Phylogenomic databases

KOiK00548.

Family and domain databases

Gene3Di1.10.1240.10. 1 hit.
3.10.196.10. 1 hit.
3.20.20.20. 1 hit.
3.20.20.330. 1 hit.
3.40.50.280. 1 hit.
InterProiIPR003759. Cbl-bd_cap.
IPR006158. Cobalamin-bd.
IPR011005. Dihydropteroate_synth-like.
IPR011822. MetH.
IPR000489. Pterin-binding.
IPR003726. S_MeTrfase.
IPR004223. VitB12-dep_Met_synth_activ_dom.
[Graphical view]
PfamiPF02310. B12-binding. 1 hit.
PF02607. B12-binding_2. 1 hit.
PF02965. Met_synt_B12. 1 hit.
PF00809. Pterin_bind. 1 hit.
PF02574. S-methyl_trans. 1 hit.
[Graphical view]
PIRSFiPIRSF000381. MetH. 1 hit.
SMARTiSM01018. B12-binding_2. 1 hit.
[Graphical view]
SUPFAMiSSF47644. SSF47644. 1 hit.
SSF51717. SSF51717. 1 hit.
SSF52242. SSF52242. 1 hit.
SSF56507. SSF56507. 1 hit.
SSF82282. SSF82282. 1 hit.
TIGRFAMsiTIGR02082. metH. 1 hit.
PROSITEiPS50974. ADOMET_ACTIVATION. 1 hit.
PS51332. B12_BINDING. 1 hit.
PS51337. B12_BINDING_NTER. 1 hit.
PS50970. HCY. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F6FWH1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSTLDVSAA DARADALLQA MRTRVVVADG AMGTMIQDAD PTLEDYEGHE
60 70 80 90 100
GCNEVLNVSR PDIIRSVHDA YLEVGVDAIE TNTFGANWSN LSDYGIEDRI
110 120 130 140 150
RELARAGAEL ARERADAWST PEHPRWVLGS MGPGTKLPSL GHTTYAHLKA
160 170 180 190 200
TFAEQAAGLL EGGADAILVE TSQDLLQAKA AVNGAREAMA AVGRRVPVIV
210 220 230 240 250
SVTVETTGTM LMGSEIGAAL TTLQALGVDA IGLNCATGPD QMSEHLRHLA
260 270 280 290 300
RHSEVPVACM PNAGLPELGP KGAVYPLTAP ELATAHAQFV EEFSLGLVGG
310 320 330 340 350
CCGTTPEHLR QVVEAVRGRE LTARPVEREN GVASLYSHTD LHQDASYLAI
360 370 380 390 400
GERTNANGSK AFREAMLDGR WDDVVDIARA QTRDGAHLLD VCVDYVGRDG
410 420 430 440 450
VADVREVVSR LASASTLPLV IDSTEPEVIK AGLELVGGRA VVNSVNFEDG
460 470 480 490 500
DGPTSRFARI MPLVKEHGAA VIALTIDEEG QARTAEKKVA IASRLIDTLT
510 520 530 540 550
GDWGMRVDDI IVDALTFPIA TGQEETRRDA IETIEAIREI TRRYPGVHTT
560 570 580 590 600
LGVSNVSFGL NPAARTVLNS VFLHEAVQAG LDSAIVHAAK ILPRTAIPDE
610 620 630 640 650
QWEAAEDLVR DRRRYDDEGN LVHDPLSHLL ELFSGVDSAS LRDQRAAELA
660 670 680 690 700
ALPVGERLER RIIDGARKGL EDDVEEALAL GMKALDIVNT HLLGGMKVVG
710 720 730 740 750
ELFGSGQMQL PFVLQSAEVM KAAVALLEPH MERVAGGPDE TKGTIVLATV
760 770 780 790 800
RGDVHDIGKN LVDIILTNNG YKVVNIGIKQ PISAMIEAAE QHDADVIGMS
810 820 830 840 850
GLLVKSTVVM KENLEELVSR GLEKKWPILL GGAALTRTYV EDDLASMFPG
860 870 880 890 900
TVRYARDAFE GLRLMEPLVR IARGASPDDV GLPPLRKRRH DVVKVTETAP
910 920 930 940 950
EELPARSDVA TDNPVPTPPF WGTRIVKGVQ LADYAAFLDE RATFMGQWGL
960 970 980 990 1000
KPGRGDDGAS YEELVETEGR PRLAEWLERI RTESILDPTV VYGYFPVWSE
1010 1020 1030 1040 1050
GNDLVVGHHE GPDGGSGGPV GTERLRFRFP RQRRDRHLCL ADFVKPRSWA
1060 1070 1080 1090 1100
EETGRFDVLP VQLVTVGDSV SQHTARLFEA NRYREYMELH GLSVQLTEAL
1110 1120 1130 1140 1150
AEFWHARVRD ELGFADEDPS DVEGMFKLAY RGARFSLGYP ACPDMEDRRK
1160 1170 1180 1190
VVELLRPERV GVVLSDELQL HPEQSTDAFV FHHPEAKYFS V
Length:1,191
Mass (Da):129,576
Last modified:July 27, 2011 - v1
Checksum:i31D8F09AAB86D5A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002810 Genomic DNA. Translation: AEG44545.1.
RefSeqiWP_013838937.1. NC_015588.1.
YP_004542439.1. NC_015588.1.

Genome annotation databases

EnsemblBacteriaiAEG44545; AEG44545; Isova_1799.
GeneIDi10733420.
KEGGiiva:Isova_1799.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002810 Genomic DNA. Translation: AEG44545.1 .
RefSeqi WP_013838937.1. NC_015588.1.
YP_004542439.1. NC_015588.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEG44545 ; AEG44545 ; Isova_1799 .
GeneIDi 10733420.
KEGGi iva:Isova_1799.

Phylogenomic databases

KOi K00548.

Enzyme and pathway databases

BioCyci IVAR743718:GI39-1832-MONOMER.

Family and domain databases

Gene3Di 1.10.1240.10. 1 hit.
3.10.196.10. 1 hit.
3.20.20.20. 1 hit.
3.20.20.330. 1 hit.
3.40.50.280. 1 hit.
InterProi IPR003759. Cbl-bd_cap.
IPR006158. Cobalamin-bd.
IPR011005. Dihydropteroate_synth-like.
IPR011822. MetH.
IPR000489. Pterin-binding.
IPR003726. S_MeTrfase.
IPR004223. VitB12-dep_Met_synth_activ_dom.
[Graphical view ]
Pfami PF02310. B12-binding. 1 hit.
PF02607. B12-binding_2. 1 hit.
PF02965. Met_synt_B12. 1 hit.
PF00809. Pterin_bind. 1 hit.
PF02574. S-methyl_trans. 1 hit.
[Graphical view ]
PIRSFi PIRSF000381. MetH. 1 hit.
SMARTi SM01018. B12-binding_2. 1 hit.
[Graphical view ]
SUPFAMi SSF47644. SSF47644. 1 hit.
SSF51717. SSF51717. 1 hit.
SSF52242. SSF52242. 1 hit.
SSF56507. SSF56507. 1 hit.
SSF82282. SSF82282. 1 hit.
TIGRFAMsi TIGR02082. metH. 1 hit.
PROSITEi PS50974. ADOMET_ACTIVATION. 1 hit.
PS51332. B12_BINDING. 1 hit.
PS51337. B12_BINDING_NTER. 1 hit.
PS50970. HCY. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 225Imported.

Entry informationi

Entry nameiF6FWH1_ISOV2
AccessioniPrimary (citable) accession number: F6FWH1
Entry historyi
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3