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F6FWH1

- F6FWH1_ISOV2

UniProt

F6FWH1 - F6FWH1_ISOV2

Protein
Submitted name:

Methionine synthase

Gene

Isova_1799

Organism
Isoptericola variabilis (strain 225)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 17 (01 Oct 2014)
      Sequence version 1 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation
    Cobalamin.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi235 – 2351ZincUniRule annotation
    Metal bindingi301 – 3011ZincUniRule annotation
    Metal bindingi302 – 3021ZincUniRule annotation
    Metal bindingi755 – 7551Cobalt (cobalamin axial ligand)UniRule annotation
    Binding sitei939 – 9391S-adenosyl-L-methionine
    Binding sitei1134 – 11341S-adenosyl-L-methionine; via carbonyl oxygen
    Binding sitei1138 – 11381Cobalamin; via carbonyl oxygen

    GO - Molecular functioni

    1. cobalamin binding Source: UniProtKB-KW
    2. methionine synthase activity Source: UniProtKB-EC
    3. S-adenosylmethionine-homocysteine S-methyltransferase activity Source: InterPro
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. pteridine-containing compound metabolic process Source: InterPro

    Keywords - Molecular functioni

    MethyltransferaseImported, Transferase

    Keywords - Ligandi

    CobalaminUniRule annotation, Cobalt, Metal-bindingUniRule annotation, S-adenosyl-L-methionineUniRule annotation, ZincUniRule annotation

    Enzyme and pathway databases

    BioCyciIVAR743718:GI39-1832-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Methionine synthaseImported (EC:2.1.1.13Imported)
    Gene namesi
    Ordered Locus Names:Isova_1799Imported
    OrganismiIsoptericola variabilis (strain 225)Imported
    Taxonomic identifieri743718 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaePromicromonosporaceaeIsoptericola
    ProteomesiUP000009236: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni832 – 8332Cobalamin-binding
    Regioni1188 – 11892S-adenosyl-L-methionine binding

    Phylogenomic databases

    KOiK00548.

    Family and domain databases

    Gene3Di1.10.1240.10. 1 hit.
    3.10.196.10. 1 hit.
    3.20.20.20. 1 hit.
    3.20.20.330. 1 hit.
    3.40.50.280. 1 hit.
    InterProiIPR003759. Cbl-bd_cap.
    IPR006158. Cobalamin-bd.
    IPR011005. Dihydropteroate_synth-like.
    IPR011822. MetH.
    IPR000489. Pterin-binding.
    IPR003726. S_MeTrfase.
    IPR004223. VitB12-dep_Met_synth_activ_dom.
    [Graphical view]
    PfamiPF02310. B12-binding. 1 hit.
    PF02607. B12-binding_2. 1 hit.
    PF02965. Met_synt_B12. 1 hit.
    PF00809. Pterin_bind. 1 hit.
    PF02574. S-methyl_trans. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000381. MetH. 1 hit.
    SMARTiSM01018. B12-binding_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF47644. SSF47644. 1 hit.
    SSF51717. SSF51717. 1 hit.
    SSF52242. SSF52242. 1 hit.
    SSF56507. SSF56507. 1 hit.
    SSF82282. SSF82282. 1 hit.
    TIGRFAMsiTIGR02082. metH. 1 hit.
    PROSITEiPS50974. ADOMET_ACTIVATION. 1 hit.
    PS51332. B12_BINDING. 1 hit.
    PS51337. B12_BINDING_NTER. 1 hit.
    PS50970. HCY. 1 hit.
    PS50972. PTERIN_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F6FWH1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSTLDVSAA DARADALLQA MRTRVVVADG AMGTMIQDAD PTLEDYEGHE     50
    GCNEVLNVSR PDIIRSVHDA YLEVGVDAIE TNTFGANWSN LSDYGIEDRI 100
    RELARAGAEL ARERADAWST PEHPRWVLGS MGPGTKLPSL GHTTYAHLKA 150
    TFAEQAAGLL EGGADAILVE TSQDLLQAKA AVNGAREAMA AVGRRVPVIV 200
    SVTVETTGTM LMGSEIGAAL TTLQALGVDA IGLNCATGPD QMSEHLRHLA 250
    RHSEVPVACM PNAGLPELGP KGAVYPLTAP ELATAHAQFV EEFSLGLVGG 300
    CCGTTPEHLR QVVEAVRGRE LTARPVEREN GVASLYSHTD LHQDASYLAI 350
    GERTNANGSK AFREAMLDGR WDDVVDIARA QTRDGAHLLD VCVDYVGRDG 400
    VADVREVVSR LASASTLPLV IDSTEPEVIK AGLELVGGRA VVNSVNFEDG 450
    DGPTSRFARI MPLVKEHGAA VIALTIDEEG QARTAEKKVA IASRLIDTLT 500
    GDWGMRVDDI IVDALTFPIA TGQEETRRDA IETIEAIREI TRRYPGVHTT 550
    LGVSNVSFGL NPAARTVLNS VFLHEAVQAG LDSAIVHAAK ILPRTAIPDE 600
    QWEAAEDLVR DRRRYDDEGN LVHDPLSHLL ELFSGVDSAS LRDQRAAELA 650
    ALPVGERLER RIIDGARKGL EDDVEEALAL GMKALDIVNT HLLGGMKVVG 700
    ELFGSGQMQL PFVLQSAEVM KAAVALLEPH MERVAGGPDE TKGTIVLATV 750
    RGDVHDIGKN LVDIILTNNG YKVVNIGIKQ PISAMIEAAE QHDADVIGMS 800
    GLLVKSTVVM KENLEELVSR GLEKKWPILL GGAALTRTYV EDDLASMFPG 850
    TVRYARDAFE GLRLMEPLVR IARGASPDDV GLPPLRKRRH DVVKVTETAP 900
    EELPARSDVA TDNPVPTPPF WGTRIVKGVQ LADYAAFLDE RATFMGQWGL 950
    KPGRGDDGAS YEELVETEGR PRLAEWLERI RTESILDPTV VYGYFPVWSE 1000
    GNDLVVGHHE GPDGGSGGPV GTERLRFRFP RQRRDRHLCL ADFVKPRSWA 1050
    EETGRFDVLP VQLVTVGDSV SQHTARLFEA NRYREYMELH GLSVQLTEAL 1100
    AEFWHARVRD ELGFADEDPS DVEGMFKLAY RGARFSLGYP ACPDMEDRRK 1150
    VVELLRPERV GVVLSDELQL HPEQSTDAFV FHHPEAKYFS V 1191
    Length:1,191
    Mass (Da):129,576
    Last modified:July 27, 2011 - v1
    Checksum:i31D8F09AAB86D5A9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002810 Genomic DNA. Translation: AEG44545.1.
    RefSeqiYP_004542439.1. NC_015588.1.

    Genome annotation databases

    EnsemblBacteriaiAEG44545; AEG44545; Isova_1799.
    GeneIDi10733420.
    KEGGiiva:Isova_1799.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002810 Genomic DNA. Translation: AEG44545.1 .
    RefSeqi YP_004542439.1. NC_015588.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEG44545 ; AEG44545 ; Isova_1799 .
    GeneIDi 10733420.
    KEGGi iva:Isova_1799.

    Phylogenomic databases

    KOi K00548.

    Enzyme and pathway databases

    BioCyci IVAR743718:GI39-1832-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1240.10. 1 hit.
    3.10.196.10. 1 hit.
    3.20.20.20. 1 hit.
    3.20.20.330. 1 hit.
    3.40.50.280. 1 hit.
    InterProi IPR003759. Cbl-bd_cap.
    IPR006158. Cobalamin-bd.
    IPR011005. Dihydropteroate_synth-like.
    IPR011822. MetH.
    IPR000489. Pterin-binding.
    IPR003726. S_MeTrfase.
    IPR004223. VitB12-dep_Met_synth_activ_dom.
    [Graphical view ]
    Pfami PF02310. B12-binding. 1 hit.
    PF02607. B12-binding_2. 1 hit.
    PF02965. Met_synt_B12. 1 hit.
    PF00809. Pterin_bind. 1 hit.
    PF02574. S-methyl_trans. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000381. MetH. 1 hit.
    SMARTi SM01018. B12-binding_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47644. SSF47644. 1 hit.
    SSF51717. SSF51717. 1 hit.
    SSF52242. SSF52242. 1 hit.
    SSF56507. SSF56507. 1 hit.
    SSF82282. SSF82282. 1 hit.
    TIGRFAMsi TIGR02082. metH. 1 hit.
    PROSITEi PS50974. ADOMET_ACTIVATION. 1 hit.
    PS51332. B12_BINDING. 1 hit.
    PS51337. B12_BINDING_NTER. 1 hit.
    PS50970. HCY. 1 hit.
    PS50972. PTERIN_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 225Imported.

    Entry informationi

    Entry nameiF6FWH1_ISOV2
    AccessioniPrimary (citable) accession number: F6FWH1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 27, 2011
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 17 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3