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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Isoptericola variabilis (strain 225)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei171 – 1711UniRule annotation
Active sitei569 – 5691UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, PyruvateImported

Enzyme and pathway databases

BioCyciIVAR743718:GI39-2962-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotationSAAS annotation (EC:4.1.1.31UniRule annotationSAAS annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotation
Ordered Locus Names:Isova_2904Imported
OrganismiIsoptericola variabilis (strain 225)Imported
Taxonomic identifieri743718 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaePromicromonosporaceaeIsoptericola
ProteomesiUP000009236: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

KOiK01595.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 2 hits.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F6FW45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSENQAQPTG VVTDPSPASA GARERVVARH EMPDPLRDDI RLLGGLLGTV
60 70 80 90 100
LREAGGQDLL DDVERLRELT IRAYGSDDGG TALAEAADLV AGFPLERAEQ
110 120 130 140 150
VARAFTCYFH LANLAEEYHR VRVLRQRETE AGAAVDESLP HAFTQLAEEV
160 170 180 190 200
GRDEALRRLS ELEFRPVLTA HPTEARRRAV SGAVRRISNL LAERDTMRPG
210 220 230 240 250
GTSLVENERR LLAEIDTMWR TSPIRAAKPT VLDEVKTAMG VFDATLFNTF
260 270 280 290 300
PEVYRRLDDW LLDGDAGRAA PVARPFVFLG SWIGGDRDGN PNVTAEVTRQ
310 320 330 340 350
AATLAAEHAL TALEEAARQV GRKLTLDEAG TPPSSALKAL WQRLRQLSED
360 370 380 390 400
LTAQAAAVSP REPHRAAVLA IAGRIGATRR RDADLAYRRP EELEAELRVV
410 420 430 440 450
QDSLVEAGAP RAAYGDLQKL VWQVQTFGFH LAEIEVRQHS QVHAAALDEI
460 470 480 490 500
AEKGVHGDLS DRTREVLDTF RALGAVQRRF GERAARRYIV SFTQAPEHLA
510 520 530 540 550
AVYHLAELAF EDAEDIPVID AIPLFETFAD LEASVDILEA ALELPQVQRR
560 570 580 590 600
LAANGRRVEV MLGYSDSSKD VGPVAATLAL HSAQSRIAEW ARRHDITLTL
610 620 630 640 650
FHGRGGALGR GGGPANRAVL AQPPHSVDGR FKLTEQGEVI LARYGDPTIA
660 670 680 690 700
ARHIEQVAAA TLLASAPSTE KRNAATAERF AHVASSLDAS SRARFHALVK
710 720 730 740 750
SEGFPQWFAQ VTPLEEIGLL PIGSRPAKRG LSVNSLDDLR AIPWVFSWSQ
760 770 780 790 800
ARINLAGWFG LGTALREFGD SPERIAELQA AYREWPLFAT LLDNVEMSLA
810 820 830 840 850
KTDERIAAQY LALGDRDDLA QMVLDELRLT REWVLRVTGN EWPLANRRVL
860 870 880 890 900
GRAVQLRSPY VDALSLLQVR ALRALRTEGA SEGVTAESGK WVDGGYKDRW
910
QHLLLLTVNG VSAGLQNTG
Length:919
Mass (Da):100,778
Last modified:July 27, 2011 - v1
Checksum:i4D5BD86169F011D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002810 Genomic DNA. Translation: AEG45589.1.
RefSeqiYP_004543483.1. NC_015588.1.

Genome annotation databases

EnsemblBacteriaiAEG45589; AEG45589; Isova_2904.
GeneIDi10734552.
KEGGiiva:Isova_2904.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002810 Genomic DNA. Translation: AEG45589.1.
RefSeqiYP_004543483.1. NC_015588.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEG45589; AEG45589; Isova_2904.
GeneIDi10734552.
KEGGiiva:Isova_2904.

Phylogenomic databases

KOiK01595.

Enzyme and pathway databases

BioCyciIVAR743718:GI39-2962-MONOMER.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 2 hits.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 225Imported.

Entry informationi

Entry nameiF6FW45_ISOV2
AccessioniPrimary (citable) accession number: F6FW45
Entry historyi
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: March 4, 2015
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.