Skip Header

Contribute Send feedback
Read comments (?) or add your own

F6FSX4 (F6FSX4_ISOV2) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 14. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Phosphoribosylamine--glycine ligase HAMAP-Rule MF_00138
EC=6.3.4.13 HAMAP-Rule MF_00138
Alternative name(s):
GARS HAMAP-Rule MF_00138
Glycinamide ribonucleotide synthetase HAMAP-Rule MF_00138
Phosphoribosylglycinamide synthetase HAMAP-Rule MF_00138
Gene names
Name:purD HAMAP-Rule MF_00138
Ordered Locus Names:Isova_0314
OrganismIsoptericola variabilis (strain 225) [Complete proteome] [HAMAP]
Taxonomic identifier743718 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Promicromonosporaceae › Isoptericola ›

Protein attributes

Sequence length436 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide. HAMAP-Rule MF_00138

Cofactor

Binds (magnesium or manganese,ion) per subunit By similarity. HAMAP-Rule MF_00138

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. HAMAP-Rule MF_00138

Sequence similarities

Belongs to the GARS family. HAMAP-Rule MF_00138

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00138

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain115 – 318204ATP-grasp By similarity HAMAP-Rule MF_00138
Nucleotide binding141 – 19959ATP By similarity HAMAP-Rule MF_00138

Sites

Metal binding2881Magnesium or manganese By similarity HAMAP-Rule MF_00138
Metal binding2901Magnesium or manganese By similarity HAMAP-Rule MF_00138

Sequences

Sequence LengthMass (Da)Tools
F6FSX4 [UniParc].

Last modified July 27, 2011. Version 1.
Checksum: 19277D55BC5B6D05

FASTA43644,307
        10         20         30         40         50         60 
MKILVVGTGA REHAIVHALA SESDGTGAQA APVHELHAAP GNPGMGQQAT LHAVDANDGA 

        70         80         90        100        110        120 
AVAVLARSLG VDLVVVGPEA PLVAGVADAV REAGIPCFGP SAEAARLEGS KAFAKDVMAA 

       130        140        150        160        170        180 
AGVPTATAYV CTTLDEVAAA LDAFGAPYVV KDDGLAAGKG VVVTSSREDA LEHARAALEA 

       190        200        210        220        230        240 
RGAEGRVVVE EYLDGPEVSL FCLSDGSTVV PMVPAQDFKR VGDDDAGPNT GGMGAYTPLD 

       250        260        270        280        290        300 
WAPSGLVQEV VDRIAQPTID EMARRGTPFS GVLYVGLALT SRGTRVVEFN ARFGDPEIQA 

       310        320        330        340        350        360 
VLARLRTPLS GVLLAAARGE LATVEPLRWS DDAVVNVVVA SEGYPATPRT GDPITGIDEA 

       370        380        390        400        410        420 
EATGGVHVLH AGTALSDDGT LLSAGGRVLS VVGRGPDLAA ARASAYAGVE KIRLAGAHHR 

       430 
SDIALKAERG EVRVPS

« Hide

References

[1]"Complete sequence of Isoptericola variabilis 225."
US DOE Joint Genome Institute
Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Mikhailova N., Zeytun A., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Siebers A., Allgaier M. expand/collapse author list , Thelen M., Hugenholtz P., Gladden J., Woyke T.
Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 225.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002810 Genomic DNA. Translation: AEG43115.1.
RefSeqYP_004541009.1. NC_015588.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEG43115; AEG43115; Isova_0314.
GeneID10731905.
KEGGiva:Isova_0314.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01945.

Enzyme and pathway databases

BioCycIVAR743718:GI39-317-MONOMER.
UniPathwayUPA00074; UER00125.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.600.10. 1 hit.
HAMAPMF_00138. GARS.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR020561. PRibGlycinamid_synth_ATP-grasp.
IPR000115. PRibGlycinamide_synth.
IPR020560. PRibGlycinamide_synth_C-dom.
IPR020559. PRibGlycinamide_synth_CS.
IPR020562. PRibGlycinamide_synth_N.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamPF01071. GARS_A. 1 hit.
PF02843. GARS_C. 1 hit.
PF02844. GARS_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. PreATP-grasp-like. 1 hit.
SSF51246. Rudmnt_hyb_motif. 1 hit.
TIGRFAMsTIGR00877. purD. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00184. GARS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF6FSX4_ISOV2
AccessionPrimary (citable) accession number: F6FSX4
Entry history
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: May 1, 2013
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info