ID F6FPL5_ISOV2 Unreviewed; 853 AA. AC F6FPL5; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 27-MAR-2024, entry version 54. DE RecName: Full=DNA ligase (ATP) {ECO:0000256|ARBA:ARBA00012727}; DE EC=6.5.1.1 {ECO:0000256|ARBA:ARBA00012727}; DE AltName: Full=NHEJ DNA polymerase {ECO:0000256|ARBA:ARBA00029943}; GN OrderedLocusNames=Isova_2011 {ECO:0000313|EMBL:AEG44747.1}; OS Isoptericola variabilis (strain 225). OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; OC Promicromonosporaceae; Isoptericola. OX NCBI_TaxID=743718 {ECO:0000313|Proteomes:UP000009236}; RN [1] {ECO:0000313|EMBL:AEG44747.1, ECO:0000313|Proteomes:UP000009236} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=225 {ECO:0000313|Proteomes:UP000009236}; RG US DOE Joint Genome Institute; RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., RA Peters L., Mikhailova N., Zeytun A., Han C., Tapia R., Land M., Hauser L., RA Kyrpides N., Ivanova N., Pagani I., Siebers A., Allgaier M., Thelen M., RA Hugenholtz P., Gladden J., Woyke T.; RT "Complete sequence of Isoptericola variabilis 225."; RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho- CC (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + CC diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003}; CC -!- COFACTOR: CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035; CC Evidence={ECO:0000256|ARBA:ARBA00001936}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP002810; AEG44747.1; -; Genomic_DNA. DR RefSeq; WP_013839138.1; NC_015588.1. DR AlphaFoldDB; F6FPL5; -. DR STRING; 743718.Isova_2011; -. DR KEGG; iva:Isova_2011; -. DR eggNOG; COG1793; Bacteria. DR eggNOG; COG3285; Bacteria. DR HOGENOM; CLU_008325_2_1_11; -. DR Proteomes; UP000009236; Chromosome. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC. DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW. DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW. DR CDD; cd07906; Adenylation_DNA_ligase_LigD_LigC; 1. DR CDD; cd04863; MtLigD_Pol_like; 1. DR CDD; cd07971; OBF_DNA_ligase_LigD; 1. DR Gene3D; 3.30.1490.70; -; 1. DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1. DR Gene3D; 3.90.920.10; DNA primase, PRIM domain; 1. DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1. DR InterPro; IPR012309; DNA_ligase_ATP-dep_C. DR InterPro; IPR012310; DNA_ligase_ATP-dep_cent. DR InterPro; IPR014146; LigD_ligase_dom. DR InterPro; IPR014144; LigD_PE_domain. DR InterPro; IPR014145; LigD_pol_dom. DR InterPro; IPR033649; MtLigD_Pol-like. DR InterPro; IPR012340; NA-bd_OB-fold. DR NCBIfam; TIGR02777; LigD_PE_dom; 1. DR NCBIfam; TIGR02778; ligD_pol; 1. DR NCBIfam; TIGR02779; NHEJ_ligase_lig; 1. DR PANTHER; PTHR42705; BIFUNCTIONAL NON-HOMOLOGOUS END JOINING PROTEIN LIGD; 1. DR PANTHER; PTHR42705:SF2; MULTIFUNCTIONAL NON-HOMOLOGOUS END JOINING DNA REPAIR PROTEIN LIGD; 1. DR Pfam; PF04679; DNA_ligase_A_C; 1. DR Pfam; PF01068; DNA_ligase_A_M; 1. DR Pfam; PF13298; LigD_N; 1. DR Pfam; PF21686; LigD_Prim-Pol; 1. DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1. DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1. DR PROSITE; PS50160; DNA_LIGASE_A3; 1. PE 4: Predicted; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840}; KW DNA damage {ECO:0000256|ARBA:ARBA00022763}; KW DNA recombination {ECO:0000256|ARBA:ARBA00023172}; KW DNA repair {ECO:0000256|ARBA:ARBA00023204}; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125}; KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932}; KW Exonuclease {ECO:0000256|ARBA:ARBA00022839}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}; KW Ligase {ECO:0000256|ARBA:ARBA00022598}; KW Manganese {ECO:0000256|ARBA:ARBA00023211}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268}; KW Nuclease {ECO:0000256|ARBA:ARBA00022722}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}; KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695}; KW Reference proteome {ECO:0000313|Proteomes:UP000009236}; KW Transferase {ECO:0000256|ARBA:ARBA00022679}. FT DOMAIN 624..722 FT /note="ATP-dependent DNA ligase family profile" FT /evidence="ECO:0000259|PROSITE:PS50160" FT REGION 322..348 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 471..512 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 853 AA; 94862 MW; 9985F73338F31E92 CRC64; MARSSASGGT TKQTVSVEGH RLQLTNLDKV LYPATGTTKG EVLHYLAEIA PVLIPHAANR PATRKRWPDG VDGQVFFQKN ADKSTPSWVR TRRIEHKTSA NDYVLVNDLA TLTWLGQTAT LEVHVPQWQF GRTGVRHNPD RLVLDLDPGP GAGLPECAQV ARWARAILVG MGLEPMPVTS GSKGIHLYAA LDGKQDSEQV SAVAKELARY LESEHPDLVV SDMKKSLRGG KVLVDWSQNN GNKTTIAPYS LRGRDHPTVA APRTWDELDD PDLRHLEYPE VLERVARDGD LLADLTQGHL AALEPTPEHM ARFERLEVYR SKRDPDKTPE PFGPSSPAAD APPGDTRPTF VIQEHHARRL HWDFRLEHDG VLVSWALPKG EPTDPAKNHL AVQTEDHPLE YGSFEGTIPA GEYGAGEVTI WDAGTYDLEK WVDGKEVIVT LHSERRGSRR LALIQTGGRD GDENSWLIHR TKEQPGGAGP AEEPATGRDG PGRRPRSGTA RRAPVELPDR PMLATAATQR ELRGLDAAEW AFEMKWDGFR TLATVTMPDD GTRGGEPSVR LTSRTGLDMT KTYPELQALA GMLSPDDLPA VLDGEIVALD ARGRPEFRRL QQRANLQKKG DVEAARRRVK VDLMLFDVLA LAGETLTDRT YDERRRLLER TVRPARPVHV PPAFDGDLEA ATDTSRELRL EGILAKRRSS RYAPGRRSRE WLKLKHSRMQ EVVVVGWRPL HAGEAREDDR TMGSLLLALP APQHGDGALR YVGKVGTGFR EKERTQIATR LRGIERATPP VDGVPRAEAR HARWVTPRLV GEVEYGDWTA DPTDPDLVDE ARLRHATWRG WREDKAPADV RPE //