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Protein

6-phosphofructokinase

Gene

pfkA

Organism
Mycoplasma haemofelis (strain Ohio2)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.SAAS annotation

Catalytic activityi

ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.SAAS annotation

Cofactori

Mg2+SAAS annotation

Pathwayi: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.SAAS annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgiB)
  3. 6-phosphofructokinase (pfkA)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseSAAS annotationImported, Transferase
Biological processGlycolysisSAAS annotation
LigandATP-bindingSAAS annotation, MagnesiumSAAS annotation, Metal-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMHAE859194:G1GR7-1542-MONOMER
UniPathwayiUPA00109; UER00182

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphofructokinaseSAAS annotation (EC:2.7.1.11SAAS annotation)
Gene namesi
Name:pfkAImported
Ordered Locus Names:MHF_1544Imported
OrganismiMycoplasma haemofelis (strain Ohio2)Imported
Taxonomic identifieri859194 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000007952 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmSAAS annotation

Interactioni

Subunit structurei

Homotetramer.SAAS annotation

Protein-protein interaction databases

STRINGi859194.MHF_1544

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 287PFKInterPro annotationAdd BLAST283

Sequence similaritiesi

Belongs to the phosphofructokinase type A (PFKA) family.SAAS annotation

Phylogenomic databases

eggNOGiENOG4107S9E Bacteria
COG0205 LUCA
KOiK00850
OMAiDESGGAM
OrthoDBiPOG091H01AC

Family and domain databases

InterProiView protein in InterPro
IPR022953 ATP_PFK
IPR012003 ATP_PFK_prok-type
IPR000023 Phosphofructokinase_dom
IPR035966 PKF_sf
PfamiView protein in Pfam
PF00365 PFK, 1 hit
PIRSFiPIRSF000532 ATP_PFK_prok, 1 hit
PRINTSiPR00476 PHFRCTKINASE
SUPFAMiSSF53784 SSF53784, 1 hit

Sequencei

Sequence statusi: Complete.

F6FHE6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENKKIAVLT SGGDSPAMNA TICSFVASAR SCGWDVYGVI DGYKGLIESN
60 70 80 90 100
FSKLDFRSLK DKVYCAGTCI GSSRCLEFKN DPKVREKCVE NLKREGFSCL
110 120 130 140 150
FVIGGDGSYQ GANLINKLGF PVIAAPGTID NDVSSSHFTI GFFSALEEIF
160 170 180 190 200
SAVKKIKATS DSHSQITFLE VMGRDCYDLS AFAGLASMVD YVITNKNPKS
210 220 230 240 250
VDEMYEVLEA MVQKGNRGIV VLVTERVYGE KFGFGMPSLP EFCAALEKKL
260 270 280 290 300
GRQVRASVLG YIQRGALPTS WDLFMSSSFG IKAIECLKAG ETGIALGFDG
310 320 330
RSFYSTPLDK ATLTPKNSSF KEVEFINSLY KL
Length:332
Mass (Da):36,168
Last modified:July 27, 2011 - v1
Checksum:i592163928EE30987
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002808 Genomic DNA Translation: AEG73776.1
RefSeqiWP_014584239.1, NC_017520.1

Genome annotation databases

EnsemblBacteriaiAEG73776; AEG73776; MHF_1544
KEGGimhf:MHF_1544

Similar proteinsi

Entry informationi

Entry nameiF6FHE6_MYCHI
AccessioniPrimary (citable) accession number: F6FHE6
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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