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Protein

6-phosphofructokinase

Gene

pfkA

Organism
Mycoplasma haemofelis (strain Ohio2)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.SAAS annotation

Catalytic activityi

ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.SAAS annotation

Pathway: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.SAAS annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgiB), Glucose-6-phosphate isomerase (pgiB)
  3. 6-phosphofructokinase (pfkA)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseSAAS annotationImported, Transferase

Keywords - Biological processi

GlycolysisSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, MagnesiumSAAS annotation, Metal-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMHAE859194:GLHF-1511-MONOMER.
UniPathwayiUPA00109; UER00182.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphofructokinaseSAAS annotation (EC:2.7.1.11SAAS annotation)
Gene namesi
Name:pfkAImported
Ordered Locus Names:MHF_1544Imported
OrganismiMycoplasma haemofelis (strain Ohio2)Imported
Taxonomic identifieri859194 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000007952 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi859194.MHF_1544.

Family & Domainsi

Phylogenomic databases

KOiK00850.
OMAiCGDIALH.

Family and domain databases

InterProiIPR022953. ATP_PFK.
IPR012003. ATP_PFK_prok-type.
IPR000023. Phosphofructokinase_dom.
[Graphical view]
PfamiPF00365. PFK. 1 hit.
[Graphical view]
PIRSFiPIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSiPR00476. PHFRCTKINASE.
SUPFAMiSSF53784. SSF53784. 1 hit.

Sequencei

Sequence statusi: Complete.

F6FHE6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENKKIAVLT SGGDSPAMNA TICSFVASAR SCGWDVYGVI DGYKGLIESN
60 70 80 90 100
FSKLDFRSLK DKVYCAGTCI GSSRCLEFKN DPKVREKCVE NLKREGFSCL
110 120 130 140 150
FVIGGDGSYQ GANLINKLGF PVIAAPGTID NDVSSSHFTI GFFSALEEIF
160 170 180 190 200
SAVKKIKATS DSHSQITFLE VMGRDCYDLS AFAGLASMVD YVITNKNPKS
210 220 230 240 250
VDEMYEVLEA MVQKGNRGIV VLVTERVYGE KFGFGMPSLP EFCAALEKKL
260 270 280 290 300
GRQVRASVLG YIQRGALPTS WDLFMSSSFG IKAIECLKAG ETGIALGFDG
310 320 330
RSFYSTPLDK ATLTPKNSSF KEVEFINSLY KL
Length:332
Mass (Da):36,168
Last modified:July 27, 2011 - v1
Checksum:i592163928EE30987
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002808 Genomic DNA. Translation: AEG73776.1.
RefSeqiWP_014584239.1. NC_017520.1.

Genome annotation databases

EnsemblBacteriaiAEG73776; AEG73776; MHF_1544.
KEGGimhf:MHF_1544.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002808 Genomic DNA. Translation: AEG73776.1.
RefSeqiWP_014584239.1. NC_017520.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi859194.MHF_1544.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEG73776; AEG73776; MHF_1544.
KEGGimhf:MHF_1544.

Phylogenomic databases

KOiK00850.
OMAiCGDIALH.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00182.
BioCyciMHAE859194:GLHF-1511-MONOMER.

Family and domain databases

InterProiIPR022953. ATP_PFK.
IPR012003. ATP_PFK_prok-type.
IPR000023. Phosphofructokinase_dom.
[Graphical view]
PfamiPF00365. PFK. 1 hit.
[Graphical view]
PIRSFiPIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSiPR00476. PHFRCTKINASE.
SUPFAMiSSF53784. SSF53784. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequences of two hemotropic Mycoplasmas, Mycoplasma haemofelis strain Ohio2 and Mycoplasma suis strain Illinois."
    Messick J.B., Santos A.P., Guimaraes A.M.
    J. Bacteriol. 193:2068-2069(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ohio2Imported.
  2. "The Genome of Mycoplasma haemofelis Strain Ohio2, a pathogenic hemoplasma of the cat."
    Santos A.P., Guimaraes A.M.S., SanMiguel P.J., Martin S.W., Messick J.B.
    Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Ohio2.

Entry informationi

Entry nameiF6FHE6_MYCHI
AccessioniPrimary (citable) accession number: F6FHE6
Entry historyi
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: June 24, 2015
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.