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Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Sphingobium chlorophenolicum L-1
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotationSAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 2 magnesium or manganese ions per subunit.UniRule annotation
  • Mn2+SAAS annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi255Magnesium or manganese 1UniRule annotation1
Metal bindingi271Magnesium or manganese 1UniRule annotation1
Metal bindingi271Magnesium or manganese 2UniRule annotation1
Metal bindingi273Magnesium or manganese 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported
Biological processCell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSCHL690566:G1GN4-1434-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotationSAAS annotation (EC:6.3.2.4UniRule annotationSAAS annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlUniRule annotation
ORF Names:Sphch_1419Imported
OrganismiSphingobium chlorophenolicum L-1Imported
Taxonomic identifieri690566 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingobium
Proteomesi
  • UP000007150 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi690566.Sphch_1419

Structurei

3D structure databases

ProteinModelPortaliF6EXN2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini104 – 304ATP-graspInterPro annotationAdd BLAST201

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CPF Bacteria
COG1181 LUCA
KOiK01921
OrthoDBiPOG091H00GT

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
HAMAPiMF_00047 Dala_Dala_lig, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR000291 D-Ala_lig_Van_CS
IPR005905 D_ala_D_ala
IPR011095 Dala_Dala_lig_C
IPR011127 Dala_Dala_lig_N
IPR016185 PreATP-grasp_dom_sf
PfamiView protein in Pfam
PF07478 Dala_Dala_lig_C, 1 hit
PF01820 Dala_Dala_lig_N, 1 hit
PIRSFiPIRSF039102 Ddl/VanB, 2 hits
SUPFAMiSSF52440 SSF52440, 1 hit
TIGRFAMsiTIGR01205 D_ala_D_alaTIGR, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS00843 DALA_DALA_LIGASE_1, 1 hit
PS00844 DALA_DALA_LIGASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

F6EXN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRGPWHVAV LMGGWSAERL VSLSSGEGVA KALESRGHRV TRIDMDRDVA
60 70 80 90 100
LRLSETRPDV VFNALHGVPG EDGTVQGMMD LMGLTYTHSG LATSVIAIDK
110 120 130 140 150
QLTKQALVPH GIPMPGGHIV PSASLFEGDP LPRPYVVKPV NEGSSVGVAI
160 170 180 190 200
VTEGGNYGSP IGRDVEGPWL HFDELLAEPY IRGRELTTAV LGDEALLVTE
210 220 230 240 250
LRPKSGFYDF DAKYTDGMTE HVCPAGIPQE IGEACKAIAL RAHQLLGCKG
260 270 280 290 300
ASRSDFRWDD TQGVEGLFLL EVNTQPGMTP LSLVPEQAAK LGIDYAELVE
310
RIVEDALGAA KGAKHG
Length:316
Mass (Da):33,780
Last modified:July 27, 2011 - v1
Checksum:iDF54A39744A9618C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002798 Genomic DNA Translation: AEG49108.1
RefSeqiWP_013847370.1, NC_015593.1

Genome annotation databases

EnsemblBacteriaiAEG49108; AEG49108; Sphch_1419
GeneIDi35852409
KEGGisch:Sphch_1419

Similar proteinsi

Entry informationi

Entry nameiF6EXN2_SPHCR
AccessioniPrimary (citable) accession number: F6EXN2
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: April 25, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health