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F6EXN2 (F6EXN2_SPHCR) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
ORF Names:Sphch_1419 EMBL AEG49108.1
OrganismSphingobium chlorophenolicum L-1 [Complete proteome] EMBL AEG49108.1
Taxonomic identifier690566 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingobium

Protein attributes

Sequence length316 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain104 – 304201ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding130 – 18758ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2551Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2711Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2711Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2731Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
F6EXN2 [UniParc].

Last modified July 27, 2011. Version 1.
Checksum: DF54A39744A9618C

FASTA31633,780
        10         20         30         40         50         60 
MTRGPWHVAV LMGGWSAERL VSLSSGEGVA KALESRGHRV TRIDMDRDVA LRLSETRPDV 

        70         80         90        100        110        120 
VFNALHGVPG EDGTVQGMMD LMGLTYTHSG LATSVIAIDK QLTKQALVPH GIPMPGGHIV 

       130        140        150        160        170        180 
PSASLFEGDP LPRPYVVKPV NEGSSVGVAI VTEGGNYGSP IGRDVEGPWL HFDELLAEPY 

       190        200        210        220        230        240 
IRGRELTTAV LGDEALLVTE LRPKSGFYDF DAKYTDGMTE HVCPAGIPQE IGEACKAIAL 

       250        260        270        280        290        300 
RAHQLLGCKG ASRSDFRWDD TQGVEGLFLL EVNTQPGMTP LSLVPEQAAK LGIDYAELVE 

       310 
RIVEDALGAA KGAKHG 

« Hide

References

[1]"Complete sequence of chromosome 1 of Sphingobium chlorophenolicum L-1."
US DOE Joint Genome Institute
Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Daligault H., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Turner P., Copley S., Woyke T.
Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: L-1 EMBL AEG49108.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002798 Genomic DNA. Translation: AEG49108.1.
RefSeqYP_004553614.1. NC_015593.1.

3D structure databases

ProteinModelPortalF6EXN2.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEG49108; AEG49108; Sphch_1419.
GeneID10741735.
KEGGsch:Sphch_1419.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.

Enzyme and pathway databases

BioCycSCHL690566:GJJA-1447-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF6EXN2_SPHCR
AccessionPrimary (citable) accession number: F6EXN2
Entry history
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: June 11, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)