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F6EQR2 (F6EQR2_AMYSD) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 12. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase HAMAP-Rule MF_00061
Short name=CMK HAMAP-Rule MF_00061
EC=2.7.1.148 HAMAP-Rule MF_00061
Alternative name(s):
4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase HAMAP-Rule MF_00061
Gene names
Name:ispE HAMAP-Rule MF_00061 EMBL AEF41939.1
Ordered Locus Names:AS9A_3499 EMBL AEF41939.1
OrganismAmycolicicoccus subflavus (strain DSM 45089 / DQS3-9A1) [Complete proteome] [HAMAP]
Taxonomic identifier443218 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Amycolicicoccus ›

Protein attributes

Sequence length322 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol By similarity. HAMAP-Rule MF_00061 SAAS SAAS004424

Catalytic activity

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. HAMAP-Rule MF_00061 SAAS SAAS004424

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6. HAMAP-Rule MF_00061 SAAS SAAS004424

Sequence similarities

Belongs to the GHMP kinase family. IspE subfamily. HAMAP-Rule MF_00061

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding101 – 11111ATP By similarity HAMAP-Rule MF_00061

Sites

Active site161 By similarity HAMAP-Rule MF_00061
Active site1431 By similarity HAMAP-Rule MF_00061

Sequences

Sequence LengthMass (Da)Tools
F6EQR2 [UniParc].

Last modified July 27, 2011. Version 1.
Checksum: 191821039B31520E

FASTA32233,465
        10         20         30         40         50         60 
MLHVVDEPVK VRAPAKVNLH LAVGDLRDDG YHELTTVFQA LSLYDEVAVT RGDALTVSVK 

        70         80         90        100        110        120 
GEGAREVPLD ENNLVWRAAQ LMAEKAGRSP RIHIAIRKGI PVAGGLAGGS ADAAATLVAL 

       130        140        150        160        170        180 
NTLWHLELSR GELSDLAAEL GSDVPFSLRG GTAMGIGRGE QLLPVLSRST YHWVLAFANG 

       190        200        210        220        230        240 
GLSTPAVYKE LDRLRESGTR PRLGSADDLM HALTVGDPDA LAPLLGNDLQ AAAISLKPQL 

       250        260        270        280        290        300 
RRTLRAGKDA GALAAIVSGS GPTCAFLCRD AEDAVSVGVE VSATGVCRTV RTATGPVPGA 

       310        320 
RVIDTDSGPD DPAQERAVDG GA

« Hide

References

[1]"Complete genome sequence of Amycolicicoccus subflavus DQS3-9A1T, an actinomycete isolated from crude oil-polluted soil."
Cai M., Chen W.M., Nie Y., Chi C.Q., Wang Y.N., Tang Y.Q., Li G.Y., Wu X.L.
J. Bacteriol. 193:4538-4539(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 45089 / DQS3-9A1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002786 Genomic DNA. Translation: AEF41939.1.
RefSeqYP_004494739.1. NC_015564.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEF41939; AEF41939; AS9A_3499.
GeneID10635667.
KEGGasd:AS9A_3499.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK00919.

Enzyme and pathway databases

BioCycASUB443218:GH9R-3535-MONOMER.
UniPathwayUPA00056; UER00094.

Family and domain databases

Gene3D3.30.230.10. 1 hit.
HAMAPMF_00061. IspE.
InterProIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR004424. IspE.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERPTHR20861:SF2. PTHR20861:SF2. 1 hit.
PfamPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFPIRSF010376. IspE. 1 hit.
SUPFAMSSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMsTIGR00154. ispE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameF6EQR2_AMYSD
AccessionPrimary (citable) accession number: F6EQR2
Entry history
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: April 3, 2013
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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