ID   F6DU38_DESRL            Unreviewed;       316 AA.
AC   F6DU38;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   27-MAR-2024, entry version 55.
DE   RecName: Full=DNA ligase (ATP) {ECO:0000256|ARBA:ARBA00012727};
DE            EC=6.5.1.1 {ECO:0000256|ARBA:ARBA00012727};
GN   OrderedLocusNames=Desru_1852 {ECO:0000313|EMBL:AEG60113.1};
OS   Desulforamulus ruminis (strain ATCC 23193 / DSM 2154 / NCIMB 8452 / DL)
OS   (Desulfotomaculum ruminis).
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Peptococcaceae;
OC   Desulforamulus.
OX   NCBI_TaxID=696281 {ECO:0000313|EMBL:AEG60113.1, ECO:0000313|Proteomes:UP000009234};
RN   [1] {ECO:0000313|Proteomes:UP000009234}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23193 / DSM 2154 / NCIB 8452 / DL
RC   {ECO:0000313|Proteomes:UP000009234};
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Lu M., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N.,
RA   Ivanova N., Mikhailova N., Pagani I., Stams A.J.M., Plugge C.M., Muyzer G.,
RA   Kuever J., Parshina S.N., Ivanova A.E., Nazina T.N., Brambilla E.,
RA   Spring S., Klenk H.-P., Woyke T.;
RT   "Complete sequence of Desulfotomaculum ruminis DSM 2154.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AEG60113.1, ECO:0000313|Proteomes:UP000009234}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23193 / DSM 2154 / NCIB 8452 / DL
RC   {ECO:0000313|Proteomes:UP000009234};
RX   PubMed=23408247; DOI=10.4056/sigs.3226659;
RA   Spring S., Visser M., Lu M., Copeland A., Lapidus A., Lucas S., Cheng J.F.,
RA   Han C., Tapia R., Goodwin L.A., Pitluck S., Ivanova N., Land M., Hauser L.,
RA   Larimer F., Rohde M., Goker M., Detter J.C., Kyrpides N.C., Woyke T.,
RA   Schaap P.J., Plugge C.M., Muyzer G., Kuever J., Pereira I.A.,
RA   Parshina S.N., Bernier-Latmani R., Stams A.J., Klenk H.P.;
RT   "Complete genome sequence of the sulfate-reducing firmicute
RT   Desulfotomaculum ruminis type strain (DL(T)).";
RL   Stand. Genomic Sci. 7:304-319(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC         (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP +
CC         diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003};
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DR   EMBL; CP002780; AEG60113.1; -; Genomic_DNA.
DR   RefSeq; WP_013841877.1; NC_015589.1.
DR   AlphaFoldDB; F6DU38; -.
DR   STRING; 696281.Desru_1852; -.
DR   KEGG; dru:Desru_1852; -.
DR   eggNOG; COG1793; Bacteria.
DR   HOGENOM; CLU_008325_4_0_9; -.
DR   Proteomes; UP000009234; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   CDD; cd07906; Adenylation_DNA_ligase_LigD_LigC; 1.
DR   CDD; cd07971; OBF_DNA_ligase_LigD; 1.
DR   Gene3D; 3.30.1490.70; -; 1.
DR   Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR014146; LigD_ligase_dom.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   NCBIfam; TIGR02779; NHEJ_ligase_lig; 1.
DR   PANTHER; PTHR45674:SF15; DNA LIGASE (ATP); 1.
DR   PANTHER; PTHR45674; DNA LIGASE 1/3 FAMILY MEMBER; 1.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   4: Predicted;
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:AEG60113.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009234}.
FT   DOMAIN          116..228
FT                   /note="ATP-dependent DNA ligase family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50160"
SQ   SEQUENCE   316 AA;  35897 MW;  47FF43D12998D551 CRC64;
     MRQEKELPNL KPMLAVKAAP FDSDDYLYEI KWDGYRALAY LNQQTLLYSR NQLDLTKSFP
     DLQGLHLRVK QKPLILDGEI VVLKDGKPSF SALQSRGKLS DPLKIRRLCQ QNPATFVVFD
     VLFSNGRNLM NLPLLQRKKF LEEMAEQGPD LIVSQYVLGS GCEFFRVVKA AGLEGMVAKR
     LDSPYLPGKR SGYWKKIRWV QSADLVICGW EKGEGQRLLG ALILGVPEKG GWVYMGKVGT
     GFSREEEKRI ITLLKPLEGH PPFSSLPDED FRKTVWVCPE LVCEVTFSEI SPEGRLRHPS
     YKGLRKDKKA EECGHL
//