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Protein

Aspartate carbamoyltransferase

Gene

pyrB

Organism
Thermus thermophilus (strain SG0.5JP17-16)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.UniRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes (S)-dihydroorotate from bicarbonate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Carbamoyl-phosphate synthase large chain (carB), Carbamoyl-phosphate synthase small chain (carA)
  2. Aspartate carbamoyltransferase (pyrB)
  3. Dihydroorotase (pyrC)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-dihydroorotate from bicarbonate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationImported
Biological processPyrimidine biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciTTHE762633:G1GY5-814-MONOMER.
UniPathwayiUPA00070; UER00116.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate carbamoyltransferaseUniRule annotation (EC:2.1.3.2UniRule annotation)
Alternative name(s):
Aspartate transcarbamylaseUniRule annotation
Short name:
ATCaseUniRule annotation
Gene namesi
Name:pyrBUniRule annotation
Ordered Locus Names:Ththe16_0784Imported
OrganismiThermus thermophilus (strain SG0.5JP17-16)Imported
Taxonomic identifieri762633 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000009233 Componenti: Chromosome

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 145OTCace_NInterPro annotationAdd BLAST144
Domaini151 – 294OTCaceInterPro annotationAdd BLAST144

Sequence similaritiesi

Belongs to the ATCase/OTCase family.UniRule annotation

Phylogenomic databases

KOiK00609.
OMAiWCDVANM.
OrthoDBiPOG091H00PQ.

Family and domain databases

Gene3Di3.40.50.1370. 3 hits.
HAMAPiMF_00001. Asp_carb_tr. 1 hit.
InterProiView protein in InterPro
IPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR036901. Asp/Orn_carbamoylTrfase_sf.
IPR002082. Asp_carbamoyltransf.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
PANTHERiPTHR11405:SF16. PTHR11405:SF16. 1 hit.
PfamiView protein in Pfam
PF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
PRINTSiPR00100. AOTCASE.
PR00101. ATCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00670. asp_carb_tr. 1 hit.
PROSITEiView protein in PROSITE
PS00097. CARBAMOYLTRANSFERASE. 1 hit.

Sequencei

Sequence statusi: Complete.

F6DG38-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRHLLDFQGW TRPEVESLLD TARVMREVLE RPVKKVPALQ GFTVATVFFE
60 70 80 90 100
PSTRTRISFE LAARRMSADV VSFAAQTSSL QKGESYKDTL LTLEAMGVDA
110 120 130 140 150
YVIRADSAGV PHQATRWVKG AVINGGDGRR AHPTQALLDA YTLLEALGTL
160 170 180 190 200
EGKKVAIVGD ILHSRVARSN AELLPLLGAQ VFCAGPPSLL PQSLPGAHLT
210 220 230 240 250
PRLEEALEEA DAVMVLRLQK ERMEAGLVHL EDYVARYQVT EKRLALAKPQ
260 270 280 290 300
APLLHPGPMN RDVELEGTLA DSARSLVNRQ VQNGVAVRMA VLYHLLVGKG

R
Length:301
Mass (Da):32,935
Last modified:July 27, 2011 - v1
Checksum:i89517D65E8C5FBA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002777 Genomic DNA. Translation: AEG33202.1.
RefSeqiWP_014510153.1. NC_017272.1.

Genome annotation databases

EnsemblBacteriaiAEG33202; AEG33202; Ththe16_0784.
KEGGitts:Ththe16_0784.
PATRICifig|762633.3.peg.783.

Similar proteinsi

Entry informationi

Entry nameiF6DG38_THETG
AccessioniPrimary (citable) accession number: F6DG38
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported