ID   F6DF94_THETG            Unreviewed;       858 AA.
AC   F6DF94;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   27-MAR-2024, entry version 61.
DE   RecName: Full=Phosphoenolpyruvate carboxylase {ECO:0000256|ARBA:ARBA00022419, ECO:0000256|HAMAP-Rule:MF_00595};
DE            Short=PEPC {ECO:0000256|HAMAP-Rule:MF_00595};
DE            Short=PEPCase {ECO:0000256|HAMAP-Rule:MF_00595};
DE            EC=4.1.1.31 {ECO:0000256|ARBA:ARBA00012305, ECO:0000256|HAMAP-Rule:MF_00595};
GN   Name=ppc {ECO:0000256|HAMAP-Rule:MF_00595};
GN   OrderedLocusNames=Ththe16_0631 {ECO:0000313|EMBL:AEG33052.1};
OS   Thermus thermophilus (strain SG0.5JP17-16).
OC   Bacteria; Deinococcota; Deinococci; Thermales; Thermaceae; Thermus.
OX   NCBI_TaxID=762633 {ECO:0000313|EMBL:AEG33052.1, ECO:0000313|Proteomes:UP000009233};
RN   [1] {ECO:0000313|Proteomes:UP000009233}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SG0.5JP17-16 {ECO:0000313|Proteomes:UP000009233};
RA   Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Peters L., Mikhailova N., Teshima H., Han C., Tapia R., Land M., Hauser L.,
RA   Kyrpides N., Ivanova N., Pagani I., Allgaier M., Hugenholtz P., Singer S.,
RA   Gladden J., Woyke T.;
RT   "Complete sequence of chromosome of Thermus thermophilus SG0.5JP17-16.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Forms oxaloacetate, a four-carbon dicarboxylic acid source
CC       for the tricarboxylic acid cycle. {ECO:0000256|ARBA:ARBA00003670,
CC       ECO:0000256|HAMAP-Rule:MF_00595}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=oxaloacetate + phosphate = hydrogencarbonate +
CC         phosphoenolpyruvate; Xref=Rhea:RHEA:28370, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:17544, ChEBI:CHEBI:43474, ChEBI:CHEBI:58702; EC=4.1.1.31;
CC         Evidence={ECO:0000256|ARBA:ARBA00001071, ECO:0000256|HAMAP-
CC         Rule:MF_00595};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946, ECO:0000256|HAMAP-
CC         Rule:MF_00595};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000256|HAMAP-Rule:MF_00595}.
CC   -!- SIMILARITY: Belongs to the PEPCase type 1 family.
CC       {ECO:0000256|ARBA:ARBA00008346, ECO:0000256|HAMAP-Rule:MF_00595}.
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DR   EMBL; CP002777; AEG33052.1; -; Genomic_DNA.
DR   RefSeq; WP_014510045.1; NC_017272.1.
DR   AlphaFoldDB; F6DF94; -.
DR   KEGG; tts:Ththe16_0631; -.
DR   PATRIC; fig|762633.3.peg.633; -.
DR   HOGENOM; CLU_006557_2_0_0; -.
DR   Proteomes; UP000009233; Chromosome.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008964; F:phosphoenolpyruvate carboxylase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015977; P:carbon fixation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006107; P:oxaloacetate metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   HAMAP; MF_00595; PEPcase_type1; 1.
DR   InterPro; IPR021135; PEP_COase.
DR   InterPro; IPR022805; PEP_COase_bac/pln-type.
DR   InterPro; IPR018129; PEP_COase_Lys_AS.
DR   InterPro; IPR033129; PEPCASE_His_AS.
DR   InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR   PANTHER; PTHR30523; PHOSPHOENOLPYRUVATE CARBOXYLASE; 1.
DR   PANTHER; PTHR30523:SF6; PHOSPHOENOLPYRUVATE CARBOXYLASE; 1.
DR   Pfam; PF00311; PEPcase; 1.
DR   PRINTS; PR00150; PEPCARBXLASE.
DR   SUPFAM; SSF51621; Phosphoenolpyruvate/pyruvate domain; 1.
DR   PROSITE; PS00781; PEPCASE_1; 1.
DR   PROSITE; PS00393; PEPCASE_2; 1.
PE   3: Inferred from homology;
KW   Carbon dioxide fixation {ECO:0000256|ARBA:ARBA00023300, ECO:0000256|HAMAP-
KW   Rule:MF_00595};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|HAMAP-Rule:MF_00595};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|HAMAP-Rule:MF_00595};
KW   Pyruvate {ECO:0000313|EMBL:AEG33052.1}.
FT   ACT_SITE        145
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00595,
FT                   ECO:0000256|PROSITE-ProRule:PRU10111"
FT   ACT_SITE        531
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00595,
FT                   ECO:0000256|PROSITE-ProRule:PRU10112"
SQ   SEQUENCE   858 AA;  96613 MW;  1CE77F6A46C8D1F8 CRC64;
     MSQDPFALLK AEVDLLGRLL GEAIRTLSGE RFFALVEEVR ALAKARRQGD EAAGEALLAR
     VEGLSTEEGE ALVRAFTHYF HLVNLAEERH RVRVNRLRAQ AETLENPRPE GFLALAKALK
     ERGLSLEEAE AHLNRLELLL TFTAHPTETR RRTLRHHLEA LQRELEAGDR ERLAARVALL
     YGTEEVRKAR PTVEDEIKGG LYYLPTTLWE AVPRVVAGLE AALERVYGRR PRLKSPVRFR
     SWIGGDRDGN PFVTPEVTAF AGRYAREVAR RRFLEALEDL VRDLSLAETR VPVPREVRER
     GEGVERFPGE PYRRFFAALY RALEREEATT EGLLAALKAA ERGLREVGLG QVAEAFLDPL
     EARLSAFGLE LAPLDLREES GRLLEAVAEL LRVGGVHPDF LALPQEERER LLTEELKTAR
     PLLPVGEAPK GEALRVALGA LKAWRDKGAH VVSMTHHPED LLAVFLLARE VGLYRPGRPL
     PFDVVPLFET LEDLRRAPEV VRRLLKNPVF RAHAEGRGGV EVMIGYSDSN KDAGFLMANL
     ALYEAQEALS RVGEEVGLPV YFFHGRGTST ARGGGPAGRA IASLPPRSVG RRIRLTEQGE
     ALADRYSHPD LAVRHLEQML YHFALAALGP GQEPEARWRE ALAQAAEEST RRYRALLQEE
     GFFDFFEAFT PIREIGELPI ASRPVYRRGR VRDIRDLRAI PWVMAWTQVR VLLPGWYGLS
     ALEELPLDLL REMYRGWPFF ASTLEAAAMA LAKADMGVAR LYLRLVPEPL RFFYRRLAEE
     HARTVALLEA IFQAPLLHNQ RTLERQIRLR NPYVDPINIV QVELLRRYRA PGGKEDEALR
     RALLLSILGV AAGLRNAG
//