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F6DEQ7

- F6DEQ7_THETG

UniProt

F6DEQ7 - F6DEQ7_THETG

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Protein

30S ribosomal protein S12

Gene
rpsL, Ththe16_1715
Organism
Thermus thermophilus (strain SG0.5JP17-16)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit By similarity.UniRule annotation
With S4 and S5 plays an important role in translational accuracy By similarity.UniRule annotation

GO - Molecular functioni

  1. rRNA binding Source: UniProtKB-HAMAP
  2. structural constituent of ribosome Source: InterPro
  3. tRNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal proteinUniRule annotationImported

Keywords - Ligandi

RNA-binding, rRNA-bindingUniRule annotation, tRNA-bindingUniRule annotation

Enzyme and pathway databases

BioCyciTTHE762633:GLMG-1760-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
30S ribosomal protein S12UniRule annotation
Gene namesi
Name:rpsLUniRule annotation
Ordered Locus Names:Ththe16_1715Imported
OrganismiThermus thermophilus (strain SG0.5JP17-16)Imported
Taxonomic identifieri762633 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000009233: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. small ribosomal subunit Source: InterPro
Complete GO annotation...

Interactioni

Subunit structurei

Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex By similarity.UniRule annotation

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4DR1X-ray3.60L1-135[»]
4DR2X-ray3.25L1-135[»]
4DR3X-ray3.35L1-135[»]
4DR4X-ray3.97L1-135[»]
4DR5X-ray3.45L1-135[»]
4DR6X-ray3.30L1-135[»]
4DR7X-ray3.75L1-135[»]
4NXMX-ray3.65L1-135[»]
4NXNX-ray3.54L1-135[»]
ProteinModelPortaliF6DEQ7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK02950.
OMAiPALQWGY.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_00403_B. Ribosomal_S12_B.
InterProiIPR012340. NA-bd_OB-fold.
IPR006032. Ribosomal_S12/S23.
IPR005679. Ribosomal_S12_bac.
[Graphical view]
PANTHERiPTHR11652. PTHR11652. 1 hit.
PfamiPF00164. Ribosom_S12_S23. 1 hit.
[Graphical view]
PIRSFiPIRSF002133. Ribosomal_S12/S23. 1 hit.
PRINTSiPR01034. RIBOSOMALS12.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00981. rpsL_bact. 1 hit.
PROSITEiPS00055. RIBOSOMAL_S12. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F6DEQ7-1 [UniParc]FASTAAdd to Basket

« Hide

MVALPTINQL VRKGREKVRK KSKVPALKGA PFRRGVCTVV RTVTPKKPNS    50
ALRKVAKVRL TSGYEVTAYI PGEGHNLQEH SVVLIRGGRV KDLPGVRYHI 100
VRGVYDAAGV KDRKKSRSKY GTKKPKEAAK TAAKK 135
Length:135
Mass (Da):14,883
Last modified:July 27, 2011 - v1
Checksum:i287BC5D2E36913B7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002777 Genomic DNA. Translation: AEG34110.1.
RefSeqiYP_005641237.1. NC_017272.1.

Genome annotation databases

EnsemblBacteriaiAEG34110; AEG34110; Ththe16_1715.
GeneIDi12261371.
KEGGitts:Ththe16_1715.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002777 Genomic DNA. Translation: AEG34110.1 .
RefSeqi YP_005641237.1. NC_017272.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4DR1 X-ray 3.60 L 1-135 [» ]
4DR2 X-ray 3.25 L 1-135 [» ]
4DR3 X-ray 3.35 L 1-135 [» ]
4DR4 X-ray 3.97 L 1-135 [» ]
4DR5 X-ray 3.45 L 1-135 [» ]
4DR6 X-ray 3.30 L 1-135 [» ]
4DR7 X-ray 3.75 L 1-135 [» ]
4NXM X-ray 3.65 L 1-135 [» ]
4NXN X-ray 3.54 L 1-135 [» ]
ProteinModelPortali F6DEQ7.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEG34110 ; AEG34110 ; Ththe16_1715 .
GeneIDi 12261371.
KEGGi tts:Ththe16_1715.

Phylogenomic databases

KOi K02950.
OMAi PALQWGY.

Enzyme and pathway databases

BioCyci TTHE762633:GLMG-1760-MONOMER.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
HAMAPi MF_00403_B. Ribosomal_S12_B.
InterProi IPR012340. NA-bd_OB-fold.
IPR006032. Ribosomal_S12/S23.
IPR005679. Ribosomal_S12_bac.
[Graphical view ]
PANTHERi PTHR11652. PTHR11652. 1 hit.
Pfami PF00164. Ribosom_S12_S23. 1 hit.
[Graphical view ]
PIRSFi PIRSF002133. Ribosomal_S12/S23. 1 hit.
PRINTSi PR01034. RIBOSOMALS12.
SUPFAMi SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00981. rpsL_bact. 1 hit.
PROSITEi PS00055. RIBOSOMAL_S12. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequence of chromosome of Thermus thermophilus SG0.5JP17-16."
    Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Mikhailova N., Teshima H., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Allgaier M., Hugenholtz P.
    , Singer S., Gladden J., Woyke T.
    Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SG0.5JP17-16.
  2. "A structural basis for streptomycin-induced misreading of the genetic code."
    Demirci H., Murphy F., Murphy E., Gregory S.T., Dahlberg A.E., Jogl G.
    Nat. Commun. 4:1355-1355(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.25 ANGSTROMS).
  3. "A structural basis for streptomycin resistance."
    Demirci H., Murphy IV F., Murphy E., Gregory S.T., Dahlberg A.E., Jogl G.
    Submitted (DEC-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (3.54 ANGSTROMS).

Entry informationi

Entry nameiF6DEQ7_THETG
AccessioniPrimary (citable) accession number: F6DEQ7
Entry historyi
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome

External Data

Dasty 3

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