F6DEQ7 (F6DEQ7_THETG) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
30S ribosomal protein S12 RuleBase RU003623 HAMAP-Rule MF_00403

Gene names

Name:	rpsL HAMAP-Rule MF_00403
Ordered Locus Names:	Ththe16_1715 EMBL AEG34110.1

Organism

Thermus thermophilus (strain SG0.5JP17-16) [Complete proteome] [HAMAP] EMBL AEG34110.1

Taxonomic identifier

762633 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus › Thermus thermophilus

Protein attributes

Sequence length	135 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit By similarity. RuleBase RU003623 HAMAP-Rule MF_00403 With S4 and S5 plays an important role in translational accuracy By similarity. RuleBase RU003623 HAMAP-Rule MF_00403
Subunit structure	Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex By similarity. RuleBase RU003623 HAMAP-Rule MF_00403
Sequence similarities	Belongs to the ribosomal protein S12P family. RuleBase RU003622 HAMAP-Rule MF_00403

Ontologies

Keywords
Ligand	RNA-binding rRNA-binding RuleBase RU003623 HAMAP-Rule MF_00403 tRNA-binding RuleBase RU003623 HAMAP-Rule MF_00403
Molecular function	Ribonucleoprotein Ribosomal protein RuleBase RU003622 HAMAP-Rule MF_00403 EMBL AEG34110.1
Technical term	3D-structure PDB 4DR1 PDB 4DR2 PDB 4DR3 PDB 4DR4 PDB 4DR5 PDB 4DR6 PDB 4DR7 PDB 4DUY PDB 4DUZ PDB 4DV0 PDB 4DV1 PDB 4DV2 PDB 4DV3 PDB 4DV4 PDB 4DV5 PDB 4DV6 PDB 4DV7 Complete proteome
Gene Ontology (GO)
Biological_process	translation Inferred from electronic annotation. Source: HAMAP
Cellular_component	small ribosomal subunit Inferred from electronic annotation. Source: InterPro
Molecular_function	rRNA binding Inferred from electronic annotation. Source: HAMAP structural constituent of ribosome Inferred from electronic annotation. Source: InterPro tRNA binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	F6DEQ7 [UniParc]. Last modified July 27, 2011. Version 1. Checksum: 287BC5D2E36913B7	FASTA	135	14,883
	10 20 30 40 50 60 MVALPTINQL VRKGREKVRK KSKVPALKGA PFRRGVCTVV RTVTPKKPNS ALRKVAKVRL 70 80 90 100 110 120 TSGYEVTAYI PGEGHNLQEH SVVLIRGGRV KDLPGVRYHI VRGVYDAAGV KDRKKSRSKY 130 GTKKPKEAAK TAAKK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequence of chromosome of Thermus thermophilus SG0.5JP17-16." Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Mikhailova N., Teshima H., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Allgaier M., Hugenholtz P. , Singer S., Gladden J., Woyke T., . Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SG0.5JP17-16.
[2]	"A structural basis for streptomycin resistance." Demirci H., Murphy IV F., Murphy E., Gregory S.T., Dahlberg A.E., Jogl G. Submitted (FEB-2012) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (3.29 ANGSTROMS).
[3]	"A structural basis for streptomycin-induced misreading of the genetic code." Demirci H., Murphy F., Murphy E., Gregory S.T., Dahlberg A.E., Jogl G. Nat. Commun. 4:1355-1355(2013) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.25 ANGSTROMS).
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

CP002777 Genomic DNA. Translation: AEG34110.1.

RefSeq

YP_005641237.1. NC_017272.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4DR1	X-ray	3.60	L	1-135	[»]
4DR2	X-ray	3.25	L	1-135	[»]
4DR3	X-ray	3.35	L	1-135	[»]
4DR4	X-ray	3.97	L	1-135	[»]
4DR5	X-ray	3.45	L	1-135	[»]
4DR6	X-ray	3.30	L	1-135	[»]
4DR7	X-ray	3.75	L	1-135	[»]

ProteinModelPortal

F6DEQ7.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

AEG34110; AEG34110; Ththe16_1715.

GeneID

12261371.

KEGG

tts:Ththe16_1715.

Organism-specific databases

CMR

Search...

Phylogenomic databases

KO

K02950.

Family and domain databases

Gene3D

2.40.50.140. 1 hit.

HAMAP

MF_00403_B. Ribosomal_S12_B.

InterPro

IPR012340. NA-bd_OB-fold.
IPR006032. Ribosomal_S12/S23.
IPR005679. Ribosomal_S12_bac.
[Graphical view]

PANTHER

PTHR11652. PTHR11652. 1 hit.

Pfam

PF00164. Ribosomal_S12. 1 hit.
[Graphical view]

PIRSF

PIRSF002133. Ribosomal_S12/S23. 1 hit.

PRINTS

PR01034. RIBOSOMALS12.

SUPFAM

SSF50249. Nucleic_acid_OB. 1 hit.

TIGRFAMs

TIGR00981. rpsL_bact. 1 hit.

PROSITE

PS00055. RIBOSOMAL_S12. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

F6DEQ7_THETG

Accession

Primary (citable) accession number: F6DEQ7

Entry history

Integrated into UniProtKB/TrEMBL:	July 27, 2011
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)