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F6DEQ7

- F6DEQ7_THETG

UniProt

F6DEQ7 - F6DEQ7_THETG

Protein

30S ribosomal protein S12

Gene

rpsL

Organism
Thermus thermophilus (strain SG0.5JP17-16)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.UniRule annotation
    With S4 and S5 plays an important role in translational accuracy.UniRule annotation

    GO - Molecular functioni

    1. rRNA binding Source: UniProtKB-HAMAP
    2. structural constituent of ribosome Source: InterPro
    3. tRNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal proteinUniRule annotationImported

    Keywords - Ligandi

    RNA-binding, rRNA-bindingUniRule annotation, tRNA-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciTTHE762633:GLMG-1760-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    30S ribosomal protein S12UniRule annotation
    Gene namesi
    Name:rpsLUniRule annotation
    Ordered Locus Names:Ththe16_1715Imported
    OrganismiThermus thermophilus (strain SG0.5JP17-16)Imported
    Taxonomic identifieri762633 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
    ProteomesiUP000009233: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. small ribosomal subunit Source: InterPro

    Interactioni

    Subunit structurei

    Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.UniRule annotation

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4DR1X-ray3.60L1-135[»]
    4DR2X-ray3.25L1-135[»]
    4DR3X-ray3.35L1-135[»]
    4DR4X-ray3.97L1-135[»]
    4DR5X-ray3.45L1-135[»]
    4DR6X-ray3.30L1-135[»]
    4DR7X-ray3.75L1-135[»]
    4LF4X-ray3.34L1-135[»]
    4LF5X-ray3.75L1-135[»]
    4LF6X-ray3.31L1-135[»]
    4LF7X-ray3.15L1-135[»]
    4LF8X-ray3.15L1-135[»]
    4LF9X-ray3.28L1-135[»]
    4LFAX-ray3.65L1-135[»]
    4LFBX-ray3.01L1-135[»]
    4LFCX-ray3.60L1-135[»]
    4NXMX-ray3.65L1-135[»]
    4NXNX-ray3.54L1-135[»]
    ProteinModelPortaliF6DEQ7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein S12P family.UniRule annotation

    Phylogenomic databases

    KOiK02950.
    OMAiPALQWGY.

    Family and domain databases

    Gene3Di2.40.50.140. 1 hit.
    HAMAPiMF_00403_B. Ribosomal_S12_B.
    InterProiIPR012340. NA-bd_OB-fold.
    IPR006032. Ribosomal_S12/S23.
    IPR005679. Ribosomal_S12_bac.
    [Graphical view]
    PANTHERiPTHR11652. PTHR11652. 1 hit.
    PfamiPF00164. Ribosom_S12_S23. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002133. Ribosomal_S12/S23. 1 hit.
    PRINTSiPR01034. RIBOSOMALS12.
    SUPFAMiSSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00981. rpsL_bact. 1 hit.
    PROSITEiPS00055. RIBOSOMAL_S12. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F6DEQ7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVALPTINQL VRKGREKVRK KSKVPALKGA PFRRGVCTVV RTVTPKKPNS    50
    ALRKVAKVRL TSGYEVTAYI PGEGHNLQEH SVVLIRGGRV KDLPGVRYHI 100
    VRGVYDAAGV KDRKKSRSKY GTKKPKEAAK TAAKK 135
    Length:135
    Mass (Da):14,883
    Last modified:July 27, 2011 - v1
    Checksum:i287BC5D2E36913B7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002777 Genomic DNA. Translation: AEG34110.1.
    RefSeqiYP_005641237.1. NC_017272.1.

    Genome annotation databases

    EnsemblBacteriaiAEG34110; AEG34110; Ththe16_1715.
    GeneIDi12261371.
    KEGGitts:Ththe16_1715.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002777 Genomic DNA. Translation: AEG34110.1 .
    RefSeqi YP_005641237.1. NC_017272.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4DR1 X-ray 3.60 L 1-135 [» ]
    4DR2 X-ray 3.25 L 1-135 [» ]
    4DR3 X-ray 3.35 L 1-135 [» ]
    4DR4 X-ray 3.97 L 1-135 [» ]
    4DR5 X-ray 3.45 L 1-135 [» ]
    4DR6 X-ray 3.30 L 1-135 [» ]
    4DR7 X-ray 3.75 L 1-135 [» ]
    4LF4 X-ray 3.34 L 1-135 [» ]
    4LF5 X-ray 3.75 L 1-135 [» ]
    4LF6 X-ray 3.31 L 1-135 [» ]
    4LF7 X-ray 3.15 L 1-135 [» ]
    4LF8 X-ray 3.15 L 1-135 [» ]
    4LF9 X-ray 3.28 L 1-135 [» ]
    4LFA X-ray 3.65 L 1-135 [» ]
    4LFB X-ray 3.01 L 1-135 [» ]
    4LFC X-ray 3.60 L 1-135 [» ]
    4NXM X-ray 3.65 L 1-135 [» ]
    4NXN X-ray 3.54 L 1-135 [» ]
    ProteinModelPortali F6DEQ7.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEG34110 ; AEG34110 ; Ththe16_1715 .
    GeneIDi 12261371.
    KEGGi tts:Ththe16_1715.

    Phylogenomic databases

    KOi K02950.
    OMAi PALQWGY.

    Enzyme and pathway databases

    BioCyci TTHE762633:GLMG-1760-MONOMER.

    Family and domain databases

    Gene3Di 2.40.50.140. 1 hit.
    HAMAPi MF_00403_B. Ribosomal_S12_B.
    InterProi IPR012340. NA-bd_OB-fold.
    IPR006032. Ribosomal_S12/S23.
    IPR005679. Ribosomal_S12_bac.
    [Graphical view ]
    PANTHERi PTHR11652. PTHR11652. 1 hit.
    Pfami PF00164. Ribosom_S12_S23. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002133. Ribosomal_S12/S23. 1 hit.
    PRINTSi PR01034. RIBOSOMALS12.
    SUPFAMi SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00981. rpsL_bact. 1 hit.
    PROSITEi PS00055. RIBOSOMAL_S12. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Thermus thermophilus SG0.5JP17-16."
      Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Mikhailova N., Teshima H., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Allgaier M., Hugenholtz P.
      , Singer S., Gladden J., Woyke T.
      Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SG0.5JP17-16Imported.
    2. "A structural basis for streptomycin-induced misreading of the genetic code."
      Demirci H., Murphy F., Murphy E., Gregory S.T., Dahlberg A.E., Jogl G.
      Nat. Commun. 4:1355-1355(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.25 ANGSTROMS).
    3. "Crystal Structure of 30S ribosomal subunit from Thermus thermophilus."
      Demirci H., Belardinelli R., Carr J., Murphy IV F., Jogl G., Dahlberg A.E., Gregory S.T.
      Submitted (JUN-2013) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (3.65 ANGSTROMS).
    4. Demirci H., Belardinelli R., Carr J., Murphy IV F., Jogl G., Dahlberg A.E., Gregory S.T.
      Submitted (JUN-2013) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (3.60 ANGSTROMS).
    5. "A structural basis for streptomycin resistance."
      Demirci H., Murphy IV F., Murphy E., Gregory S.T., Dahlberg A.E., Jogl G.
      Submitted (DEC-2013) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (3.54 ANGSTROMS).

    Entry informationi

    Entry nameiF6DEQ7_THETG
    AccessioniPrimary (citable) accession number: F6DEQ7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 27, 2011
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteomeImported

    External Data

    Dasty 3