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F6DE76 (F6DE76_THETG) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Ththe16_1607 EMBL AEG34003.1
OrganismThermus thermophilus (strain SG0.5JP17-16) [Complete proteome] [HAMAP] EMBL AEG34003.1
Taxonomic identifier762633 [NCBI]
Taxonomic lineageBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Protein attributes

Sequence length319 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain120 – 315196ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding147 – 19852ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2701Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2821Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2821Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2841Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
F6DE76 [UniParc].

Last modified July 27, 2011. Version 1.
Checksum: BD43FA7201EA18CA

FASTA31934,788
        10         20         30         40         50         60 
MRVLLIAGGV SPEHEVSLLS AEGVLRHMPF PTDLAVIARD GRWLFGEKAL AALEAKAAPE 

        70         80         90        100        110        120 
GEHPFPPPLP WERYDVVFPL LHGRFGEDGT VQGFLELLGK PYVGAGVTAS ALCMDKDLSK 

       130        140        150        160        170        180 
RVLAQAGVPV VPWVAVRKGE PPMVPFDPPF FVKPANTGSS VGISRVERFQ DLEAALALAF 

       190        200        210        220        230        240 
RYDEKAVVEK ALSPVRELEV GVLGNVFGEA SPVGEVRYEA PFYDYETKYT PGRAELLIPA 

       250        260        270        280        290        300 
PLDPGTQETV QELALKAYKV LGVRGMARVD FFLAEGELYL NELNTIPGFT PTSMYPRLFE 

       310 
AGGVAYPELL RRLVELALT 

« Hide

References

[1]"Complete sequence of chromosome of Thermus thermophilus SG0.5JP17-16."
Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Mikhailova N., Teshima H., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Allgaier M., Hugenholtz P. expand/collapse author list , Singer S., Gladden J., Woyke T.
Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SG0.5JP17-16.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002777 Genomic DNA. Translation: AEG34003.1.
RefSeqYP_005641130.1. NC_017272.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEG34003; AEG34003; Ththe16_1607.
GeneID12261263.
KEGGtts:Ththe16_1607.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.
OMAWREAARY.

Enzyme and pathway databases

BioCycTTHE762633:GLMG-1652-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF6DE76_THETG
AccessionPrimary (citable) accession number: F6DE76
Entry history
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: February 19, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)