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F6DB89

- F6DB89_THICA

UniProt

F6DB89 - F6DB89_THICA

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Protein
Submitted name:

Isocitrate dehydrogenase, NADP-dependent

Gene

Thicy_0053

Organism
Thioalkalimicrobium cyclicum (strain DSM 14477 / JCM 11371 / ALM1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei146 – 1461SubstrateUniRule annotation
Sitei256 – 2561Critical for catalysisUniRule annotation
Metal bindingi351 – 3511Magnesium or manganeseUniRule annotation
Binding sitei548 – 5481SubstrateUniRule annotation
Metal bindingi549 – 5491Magnesium or manganeseUniRule annotation
Metal bindingi553 – 5531Magnesium or manganeseUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase, NADP-dependentImported (EC:1.1.1.42Imported)
Gene namesi
Ordered Locus Names:Thicy_0053Imported
OrganismiThioalkalimicrobium cyclicum (strain DSM 14477 / JCM 11371 / ALM1)Imported
Taxonomic identifieri717773 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesPiscirickettsiaceaeThioalkalimicrobium
ProteomesiUP000009232: Chromosome

Structurei

3D structure databases

ProteinModelPortaliF6DB89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni133 – 1408Substrate bindingUniRule annotation

Phylogenomic databases

KOiK00031.
OMAiEEQRIGD.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

F6DB89-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTQSSTLIYT HTDEAPALAT YSFLPIIQAF TAAAGVEVTT RDISLAGRIL
60 70 80 90 100
ANFNEYLTAE QQTVDALTEL GELAKKPAAN IIKLPNISAS IPQLTGAIAE
110 120 130 140 150
LQAQGYAIPN YPATPQNDQE RDIKARYAKV LGSAVNPVLR EGNSDRRVAG
160 170 180 190 200
PVKAYAKAHP HSMGVWSKDS KSHVAHMQAD DFYGSELSYV SPTEDSVRIE
210 220 230 240 250
FHGEDGQITV LKAKTRLQAG EVIDASVMRV AALRAFLAEQ VADAKAQGVL
260 270 280 290 300
FSLHLKATMM KVSDPIMFGH AVEVYFAQVF ERFSDTFSKL GVSTRNGLGD
310 320 330 340 350
VYQKIQALPA AERVEIDQAL ADAMAQGPAL AMVDSDKGIS NLHVPSDVII
360 370 380 390 400
DASMPAAIRS SGQMWNAQGQ LQDMKAIIPD RCYAGVYQQT IEFCKANGAF
410 420 430 440 450
DPATMGTVPN VGLMAQKAEE YGSHDKTFEM PSAGSVQVIN EAGVVIFAHQ
460 470 480 490 500
VAKGDIWRMC QTKDIAIQDW VKLAVTRARL TNTPAIFWLD AQRPHDANLI
510 520 530 540 550
KKVENALGML DIEGLDLEIL SPVDATAKTL ARAKAGMDTI SVTGNVLRDY
560 570 580 590 600
LTDLFPILEL GTSAKMLSIV PLLAGGGLFE TGAGGSAPKH VQQLVQENFL
610 620 630 640 650
RWDSLGEFLA LAVSLEHLAQ QTKNSRINVL VDSLNQATSR FLQENRSPGR
660 670 680 690 700
KVGELDNRGS HVYLATHWAQ ALAEQQVDLS LHQQFAPLAE ALQAQLDAIL
710 720 730 740
AELAAVQGQP VDLGGYYHPD AKKAAAAMRP SKLFNAALAQ FAQGVSHGA
Length:749
Mass (Da):80,762
Last modified:July 27, 2011 - v1
Checksum:i90D38103A36B7A86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002776 Genomic DNA. Translation: AEG30829.1.
RefSeqiYP_004536308.1. NC_015581.1.

Genome annotation databases

EnsemblBacteriaiAEG30829; AEG30829; Thicy_0053.
GeneIDi10718843.
KEGGitcy:Thicy_0053.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002776 Genomic DNA. Translation: AEG30829.1 .
RefSeqi YP_004536308.1. NC_015581.1.

3D structure databases

ProteinModelPortali F6DB89.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEG30829 ; AEG30829 ; Thicy_0053 .
GeneIDi 10718843.
KEGGi tcy:Thicy_0053.

Phylogenomic databases

KOi K00031.
OMAi EEQRIGD.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Thioalkalimicrobium cyclicum ALM1."
    US DOE Joint Genome Institute
    Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Mikhailova N., Davenport K., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Kappler U., Woyke T.
    Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 14477 / JCM 11371 / ALM1Imported.

Entry informationi

Entry nameiF6DB89_THICA
AccessioniPrimary (citable) accession number: F6DB89
Entry historyi
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3