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F6DB89

- F6DB89_THICA

UniProt

F6DB89 - F6DB89_THICA

Protein
Submitted name:

Isocitrate dehydrogenase, NADP-dependent

Gene

Thicy_0053

Organism
Thioalkalimicrobium cyclicum (strain DSM 14477 / JCM 11371 / ALM1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 20 (01 Oct 2014)
      Sequence version 1 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei146 – 1461SubstrateUniRule annotation
    Sitei256 – 2561Critical for catalysisUniRule annotation
    Metal bindingi351 – 3511Magnesium or manganeseUniRule annotation
    Sitei421 – 4211Critical for catalysis
    Binding sitei548 – 5481SubstrateUniRule annotation
    Metal bindingi549 – 5491Magnesium or manganeseUniRule annotation
    Metal bindingi553 – 5531Magnesium or manganeseUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseImported

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Isocitrate dehydrogenase, NADP-dependentImported (EC:1.1.1.42Imported)
    Gene namesi
    Ordered Locus Names:Thicy_0053Imported
    OrganismiThioalkalimicrobium cyclicum (strain DSM 14477 / JCM 11371 / ALM1)Imported
    Taxonomic identifieri717773 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesPiscirickettsiaceaeThioalkalimicrobium
    ProteomesiUP000009232: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliF6DB89.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni133 – 1408Substrate bindingUniRule annotation

    Phylogenomic databases

    KOiK00031.
    OMAiEEQRIGD.

    Family and domain databases

    Gene3Di3.40.718.10. 3 hits.
    InterProiIPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PfamiPF03971. IDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    F6DB89-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTQSSTLIYT HTDEAPALAT YSFLPIIQAF TAAAGVEVTT RDISLAGRIL    50
    ANFNEYLTAE QQTVDALTEL GELAKKPAAN IIKLPNISAS IPQLTGAIAE 100
    LQAQGYAIPN YPATPQNDQE RDIKARYAKV LGSAVNPVLR EGNSDRRVAG 150
    PVKAYAKAHP HSMGVWSKDS KSHVAHMQAD DFYGSELSYV SPTEDSVRIE 200
    FHGEDGQITV LKAKTRLQAG EVIDASVMRV AALRAFLAEQ VADAKAQGVL 250
    FSLHLKATMM KVSDPIMFGH AVEVYFAQVF ERFSDTFSKL GVSTRNGLGD 300
    VYQKIQALPA AERVEIDQAL ADAMAQGPAL AMVDSDKGIS NLHVPSDVII 350
    DASMPAAIRS SGQMWNAQGQ LQDMKAIIPD RCYAGVYQQT IEFCKANGAF 400
    DPATMGTVPN VGLMAQKAEE YGSHDKTFEM PSAGSVQVIN EAGVVIFAHQ 450
    VAKGDIWRMC QTKDIAIQDW VKLAVTRARL TNTPAIFWLD AQRPHDANLI 500
    KKVENALGML DIEGLDLEIL SPVDATAKTL ARAKAGMDTI SVTGNVLRDY 550
    LTDLFPILEL GTSAKMLSIV PLLAGGGLFE TGAGGSAPKH VQQLVQENFL 600
    RWDSLGEFLA LAVSLEHLAQ QTKNSRINVL VDSLNQATSR FLQENRSPGR 650
    KVGELDNRGS HVYLATHWAQ ALAEQQVDLS LHQQFAPLAE ALQAQLDAIL 700
    AELAAVQGQP VDLGGYYHPD AKKAAAAMRP SKLFNAALAQ FAQGVSHGA 749
    Length:749
    Mass (Da):80,762
    Last modified:July 27, 2011 - v1
    Checksum:i90D38103A36B7A86
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002776 Genomic DNA. Translation: AEG30829.1.
    RefSeqiWP_013834617.1. NC_015581.1.
    YP_004536308.1. NC_015581.1.

    Genome annotation databases

    EnsemblBacteriaiAEG30829; AEG30829; Thicy_0053.
    GeneIDi10718843.
    KEGGitcy:Thicy_0053.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002776 Genomic DNA. Translation: AEG30829.1 .
    RefSeqi WP_013834617.1. NC_015581.1.
    YP_004536308.1. NC_015581.1.

    3D structure databases

    ProteinModelPortali F6DB89.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEG30829 ; AEG30829 ; Thicy_0053 .
    GeneIDi 10718843.
    KEGGi tcy:Thicy_0053.

    Phylogenomic databases

    KOi K00031.
    OMAi EEQRIGD.

    Family and domain databases

    Gene3Di 3.40.718.10. 3 hits.
    InterProi IPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    Pfami PF03971. IDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Thioalkalimicrobium cyclicum ALM1."
      US DOE Joint Genome Institute
      Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Mikhailova N., Davenport K., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Kappler U., Woyke T.
      Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 14477 / JCM 11371 / ALM1Imported.

    Entry informationi

    Entry nameiF6DB89_THICA
    AccessioniPrimary (citable) accession number: F6DB89
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 27, 2011
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3