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F6DB89

- F6DB89_THICA

UniProt

F6DB89 - F6DB89_THICA

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Protein
Submitted name: Isocitrate dehydrogenase, NADP-dependent
Gene
Thicy_0053
Organism
Thioalkalimicrobium cyclicum (strain DSM 14477 / JCM 11371 / ALM1)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei146 – 1461Substrate By similarityUniRule annotation
Sitei256 – 2561Critical for catalysis By similarityUniRule annotation
Metal bindingi351 – 3511Magnesium or manganese By similarity
Sitei421 – 4211Critical for catalysis By similarityUniRule annotation
Binding sitei548 – 5481Substrate By similarityUniRule annotation
Metal bindingi549 – 5491Magnesium or manganese By similarity
Metal bindingi553 – 5531Magnesium or manganese By similarity

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase, NADP-dependentImported (EC:1.1.1.42Imported)
Gene namesi
Ordered Locus Names:Thicy_0053Imported
OrganismiThioalkalimicrobium cyclicum (strain DSM 14477 / JCM 11371 / ALM1)Imported
Taxonomic identifieri717773 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesPiscirickettsiaceaeThioalkalimicrobium
ProteomesiUP000009232: Chromosome

Structurei

3D structure databases

ProteinModelPortaliF6DB89.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni133 – 1408Substrate binding By similarityUniRule annotation

Phylogenomic databases

KOiK00031.
OMAiEEQRIGD.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

F6DB89-1 [UniParc]FASTAAdd to Basket

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MTQSSTLIYT HTDEAPALAT YSFLPIIQAF TAAAGVEVTT RDISLAGRIL    50
ANFNEYLTAE QQTVDALTEL GELAKKPAAN IIKLPNISAS IPQLTGAIAE 100
LQAQGYAIPN YPATPQNDQE RDIKARYAKV LGSAVNPVLR EGNSDRRVAG 150
PVKAYAKAHP HSMGVWSKDS KSHVAHMQAD DFYGSELSYV SPTEDSVRIE 200
FHGEDGQITV LKAKTRLQAG EVIDASVMRV AALRAFLAEQ VADAKAQGVL 250
FSLHLKATMM KVSDPIMFGH AVEVYFAQVF ERFSDTFSKL GVSTRNGLGD 300
VYQKIQALPA AERVEIDQAL ADAMAQGPAL AMVDSDKGIS NLHVPSDVII 350
DASMPAAIRS SGQMWNAQGQ LQDMKAIIPD RCYAGVYQQT IEFCKANGAF 400
DPATMGTVPN VGLMAQKAEE YGSHDKTFEM PSAGSVQVIN EAGVVIFAHQ 450
VAKGDIWRMC QTKDIAIQDW VKLAVTRARL TNTPAIFWLD AQRPHDANLI 500
KKVENALGML DIEGLDLEIL SPVDATAKTL ARAKAGMDTI SVTGNVLRDY 550
LTDLFPILEL GTSAKMLSIV PLLAGGGLFE TGAGGSAPKH VQQLVQENFL 600
RWDSLGEFLA LAVSLEHLAQ QTKNSRINVL VDSLNQATSR FLQENRSPGR 650
KVGELDNRGS HVYLATHWAQ ALAEQQVDLS LHQQFAPLAE ALQAQLDAIL 700
AELAAVQGQP VDLGGYYHPD AKKAAAAMRP SKLFNAALAQ FAQGVSHGA 749
Length:749
Mass (Da):80,762
Last modified:July 27, 2011 - v1
Checksum:i90D38103A36B7A86
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002776 Genomic DNA. Translation: AEG30829.1.
RefSeqiWP_013834617.1. NC_015581.1.
YP_004536308.1. NC_015581.1.

Genome annotation databases

EnsemblBacteriaiAEG30829; AEG30829; Thicy_0053.
GeneIDi10718843.
KEGGitcy:Thicy_0053.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002776 Genomic DNA. Translation: AEG30829.1 .
RefSeqi WP_013834617.1. NC_015581.1.
YP_004536308.1. NC_015581.1.

3D structure databases

ProteinModelPortali F6DB89.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEG30829 ; AEG30829 ; Thicy_0053 .
GeneIDi 10718843.
KEGGi tcy:Thicy_0053.

Phylogenomic databases

KOi K00031.
OMAi EEQRIGD.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Thioalkalimicrobium cyclicum ALM1."
    US DOE Joint Genome Institute
    Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Mikhailova N., Davenport K., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Kappler U., Woyke T.
    Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 14477 / JCM 11371 / ALM1.

Entry informationi

Entry nameiF6DB89_THICA
AccessioniPrimary (citable) accession number: F6DB89
Entry historyi
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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