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F6D512

- HPRT_METPW

UniProt

F6D512 - HPRT_METPW

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Protein
Hypoxanthine/guanine phosphoribosyltransferase
Gene
hpt, MSWAN_2285
Organism
Methanobacterium paludis (strain DSM 25820 / JCM 18151 / SWAN1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis By similarity.UniRule annotation

Catalytic activityi

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. guanine phosphoribosyltransferase activity Source: UniProtKB-EC
  2. hypoxanthine phosphoribosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. IMP salvage Source: UniProtKB-UniPathway
  2. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

BioCyciMSP868131:GHW8-2339-MONOMER.
UniPathwayiUPA00591; UER00648.

Names & Taxonomyi

Protein namesi
Recommended name:
Hypoxanthine/guanine phosphoribosyltransferase (EC:2.4.2.8)
Short name:
HGPRTase
Gene namesi
Name:hpt
Ordered Locus Names:MSWAN_2285
OrganismiMethanobacterium paludis (strain DSM 25820 / JCM 18151 / SWAN1)
Taxonomic identifieri868131 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanobacterium
ProteomesiUP000009231: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 190190Hypoxanthine/guanine phosphoribosyltransferaseUniRule annotation
PRO_0000415464Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliF6D512.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK00759.
OMAiIATDIPY.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01467. Hypx_phosphoribosyltr.
InterProiIPR026597. HGPRTase-like.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F6D512-1 [UniParc]FASTAAdd to Basket

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MFEKLKKSLI EAPVVKKGDY DYFVHPITDG VPLVVPEILE EVADGVSKFG    50
NMNVDKIVCV EAMGIHIATA LSLKTGIPFV VVRKRSYGLE GEVAVHQMTG 100
YSEGELYING LNSGDRIILV DDVVSTGGTM IAVLKALKAI KVDIVDVMAV 150
IEKGKGKCIV EDATGVTVRS LVKLNVVNGK VVIKGSIDES 190
Length:190
Mass (Da):20,343
Last modified:July 27, 2011 - v1
Checksum:i99873CB2BE2460C3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002772 Genomic DNA. Translation: AEG19291.1.
RefSeqiWP_013826790.1. NC_015574.1.
YP_004521092.1. NC_015574.1.

Genome annotation databases

EnsemblBacteriaiAEG19291; AEG19291; MSWAN_2285.
GeneIDi10669814.
KEGGimew:MSWAN_2285.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002772 Genomic DNA. Translation: AEG19291.1 .
RefSeqi WP_013826790.1. NC_015574.1.
YP_004521092.1. NC_015574.1.

3D structure databases

ProteinModelPortali F6D512.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEG19291 ; AEG19291 ; MSWAN_2285 .
GeneIDi 10669814.
KEGGi mew:MSWAN_2285.

Phylogenomic databases

KOi K00759.
OMAi IATDIPY.

Enzyme and pathway databases

UniPathwayi UPA00591 ; UER00648 .
BioCyci MSP868131:GHW8-2339-MONOMER.

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
HAMAPi MF_01467. Hypx_phosphoribosyltr.
InterProi IPR026597. HGPRTase-like.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view ]
Pfami PF00156. Pribosyltran. 1 hit.
[Graphical view ]
SUPFAMi SSF53271. SSF53271. 1 hit.
PROSITEi PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Methanobacterium sp. SWAN-1."
    Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Ovchinnikova G., Chertkov O., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Cadillo-Quiroz H., Imachi H.
    , Zinder S., Liu W., Woyke T.
    Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 25820 / JCM 18151 / SWAN1.

Entry informationi

Entry nameiHPRT_METPW
AccessioniPrimary (citable) accession number: F6D512
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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