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F6D1J3

- F6D1J3_METPW

UniProt

F6D1J3 - F6D1J3_METPW

Protein

DNA ligase

Gene

lig

Organism
Methanobacterium paludis (strain DSM 25820 / JCM 18151 / SWAN1)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 18 (01 Oct 2014)
      Sequence version 1 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei256 – 2561ATPUniRule annotation
    Active sitei258 – 2581N6-AMP-lysine intermediateUniRule annotation
    Binding sitei263 – 2631ATPUniRule annotation
    Binding sitei278 – 2781ATPUniRule annotation
    Binding sitei308 – 3081ATPUniRule annotation
    Binding sitei347 – 3471ATPUniRule annotation
    Binding sitei424 – 4241ATPUniRule annotation
    Binding sitei430 – 4301ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMSP868131:GHW8-177-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:MSWAN_0175Imported
    OrganismiMethanobacterium paludis (strain DSM 25820 / JCM 18151 / SWAN1)Imported
    Taxonomic identifieri868131 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanobacterium
    ProteomesiUP000009231: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliF6D1J3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    KOiK10747.
    OMAiARVQVHK.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F6D1J3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSKINMKYM ELVEVYEALD STTKRLEKTS ILAKFFKIMG NEEPELLPIV    50
    TLMSLGRIFP TWSEEELGLG SKLLMKAISL VAGVGPDDVE NMTRDAGDIG 100
    LAAETLLKRK QQSTLFARQP LTIEKVHSNL IKITKISGNR AQNKKMEILR 150
    ELFSSASPKE AKYITRTVLE ELRVGVGEGT IKDAISEAFE VEKTAVERAH 200
    MLTNDLGLVA EVAKEEGEEG LGKLTLKPGK PVKPMLAQLS PGIKISVEEM 250
    GWALCETKYD GIRVQIHRLG DDINIFTRRL ENISNAVPEI VEYIRKSLPA 300
    CDFIVEGEII VTRDGKPISF QYILQRVRRK YDIEKMREKV PLKLYLFDVL 350
    YYDGPQIDTP FEERRRILES IVTVTEHKLE LSSQVKTTPE EIWKAEDLFT 400
    ASIKGGHEGI MIKDPHAPYM PGIRGKKMLK LKAVPETLDL VIVGGTYGKG 450
    RRAHVIGSYL LAVRDENNDF KTLAHAATGL DDNMLIELSR MVEPLIVKKM 500
    GRKVEITPSI ILEIAYSEIV KSPEYESGYS LRFPVVKRIR EDIGLDDIDT 550
    VERVDSMFKE V 561
    Length:561
    Mass (Da):63,264
    Last modified:July 27, 2011 - v1
    Checksum:i4D906B059857AFA0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002772 Genomic DNA. Translation: AEG17221.1.
    RefSeqiWP_013824723.1. NC_015574.1.
    YP_004519022.1. NC_015574.1.

    Genome annotation databases

    EnsemblBacteriaiAEG17221; AEG17221; MSWAN_0175.
    GeneIDi10667653.
    KEGGimew:MSWAN_0175.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002772 Genomic DNA. Translation: AEG17221.1 .
    RefSeqi WP_013824723.1. NC_015574.1.
    YP_004519022.1. NC_015574.1.

    3D structure databases

    ProteinModelPortali F6D1J3.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEG17221 ; AEG17221 ; MSWAN_0175 .
    GeneIDi 10667653.
    KEGGi mew:MSWAN_0175.

    Phylogenomic databases

    KOi K10747.
    OMAi ARVQVHK.

    Enzyme and pathway databases

    BioCyci MSP868131:GHW8-177-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Methanobacterium sp. SWAN-1."
      Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Ovchinnikova G., Chertkov O., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Cadillo-Quiroz H., Imachi H.
      , Zinder S., Liu W., Woyke T.
      Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 25820 / JCM 18151 / SWAN1Imported.

    Entry informationi

    Entry nameiF6D1J3_METPW
    AccessioniPrimary (citable) accession number: F6D1J3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 27, 2011
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 18 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3