ID   F6D1I6_METPW            Unreviewed;       455 AA.
AC   F6D1I6;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   27-MAR-2024, entry version 54.
DE   RecName: Full=glutamate decarboxylase {ECO:0000256|ARBA:ARBA00012421};
DE            EC=4.1.1.15 {ECO:0000256|ARBA:ARBA00012421};
GN   OrderedLocusNames=MSWAN_0168 {ECO:0000313|EMBL:AEG17214.1};
OS   Methanobacterium paludis (strain DSM 25820 / JCM 18151 / SWAN1).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanobacterium.
OX   NCBI_TaxID=868131 {ECO:0000313|EMBL:AEG17214.1, ECO:0000313|Proteomes:UP000009231};
RN   [1] {ECO:0000313|Proteomes:UP000009231}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 25820 / JCM 18151 / SWAN1
RC   {ECO:0000313|Proteomes:UP000009231};
RA   Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Peters L., Ovchinnikova G., Chertkov O., Han C., Tapia R., Land M.,
RA   Hauser L., Kyrpides N., Ivanova N., Pagani I., Cadillo-Quiroz H.,
RA   Imachi H., Zinder S., Liu W., Woyke T.;
RT   "Complete sequence of Methanobacterium sp. SWAN-1.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AEG17214.1, ECO:0000313|Proteomes:UP000009231}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 25820 / JCM 18151 / SWAN1
RC   {ECO:0000313|Proteomes:UP000009231};
RX   PubMed=24449792; DOI=10.1099/ijs.0.059964-0;
RA   Cadillo-Quiroz H., Brauer S.L., Goodson N., Yavitt J.B., Zinder S.H.;
RT   "Methanobacterium paludis sp. nov. and a novel strain of Methanobacterium
RT   lacus isolated from northern peatlands.";
RL   Int. J. Syst. Evol. Microbiol. 64:1473-1480(2014).
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933,
CC         ECO:0000256|PIRSR:PIRSR602129-50, ECO:0000256|RuleBase:RU000382};
CC   -!- SIMILARITY: Belongs to the group II decarboxylase family.
CC       {ECO:0000256|RuleBase:RU000382}.
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DR   EMBL; CP002772; AEG17214.1; -; Genomic_DNA.
DR   RefSeq; WP_013824716.1; NC_015574.1.
DR   AlphaFoldDB; F6D1I6; -.
DR   STRING; 868131.MSWAN_0168; -.
DR   GeneID; 10667646; -.
DR   KEGG; mew:MSWAN_0168; -.
DR   eggNOG; arCOG00027; Archaea.
DR   HOGENOM; CLU_019582_2_2_2; -.
DR   OrthoDB; 56891at2157; -.
DR   Proteomes; UP000009231; Chromosome.
DR   GO; GO:0004351; F:glutamate decarboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0006536; P:glutamate metabolic process; IEA:InterPro.
DR   CDD; cd06450; DOPA_deC_like; 1.
DR   Gene3D; 3.90.1150.160; -; 1.
DR   Gene3D; 4.10.280.50; -; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR010107; Glutamate_decarboxylase.
DR   InterPro; IPR002129; PyrdxlP-dep_de-COase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   NCBIfam; TIGR01788; Glu-decarb-GAD; 1.
DR   PANTHER; PTHR43321; GLUTAMATE DECARBOXYLASE; 1.
DR   PANTHER; PTHR43321:SF3; GLUTAMATE DECARBOXYLASE; 1.
DR   Pfam; PF00282; Pyridoxal_deC; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000382};
KW   Pyridoxal phosphate {ECO:0000256|PIRSR:PIRSR602129-50,
KW   ECO:0000256|RuleBase:RU000382}.
FT   MOD_RES         269
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR602129-50"
SQ   SEQUENCE   455 AA;  51972 MW;  64815717533155A8 CRC64;
     MKRSEKELTT TYGSRYFAES VPKYVMPEDG MPARAAYQLI HDELNLDGNP ALNLASFVTT
     WMEPEADKLI MESIDKNFVD NDEYPQTEKI HERVINMLAR LFNAPKECHS VGTGTIGSSE
     AIMLGLLAHK WTWKKRRQAE GKPFGKPNIV MGADVHTVWE KFALYFDVEL KLIPLERDTY
     TVTVDQVAEE IDENTICVGA VLGTTFTGQM DPINEINQLL IDIKKEKGWD IPIHVDGASG
     GFVAPFLYPD LEWDFKLQQV KSINVSGHKY GLVYPGVGWL IFRDKKDLPE ELIFKVNYLG
     GLMPNYSLNF SKGSSTIIAQ YYNFIRLGKS GYREIMENMI DNSKYLARKL EESGKFDVIN
     KDIMFPLVTM SLKNSDFTVF HLSEKLRQKG WIIPAYTLPK NAEDVAVMRM VIKENFGREM
     VDMLLDDLIE AYHTLEEEDT EKEGFETGEN PSLLY
//