F6CZA7 (F6CZA7_MARPP) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Tryptophan synthase alpha chain HAMAP-Rule MF_00131
EC=4.2.1.20 HAMAP-Rule MF_00131

Gene names

Name:	trpA HAMAP-Rule MF_00131
Ordered Locus Names:	Mar181_1605

Organism

Marinomonas posidonica (strain CECT 7376 / NCIMB 14433 / IVIA-Po-181) [Complete proteome] [HAMAP]

Taxonomic identifier

491952 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Oceanospirillaceae › Marinomonas › Marinomonas posidonica

Protein attributes

Sequence length	268 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate By similarity. HAMAP-Rule MF_00131 RuleBase RU000601 SAAS SAAS018204
Catalytic activity	L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O. HAMAP-Rule MF_00131 RuleBase RU000601 SAAS SAAS018204
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5. HAMAP-Rule MF_00131 RuleBase RU000601 SAAS SAAS018204
Subunit structure	Tetramer of two alpha and two beta chains By similarity. HAMAP-Rule MF_00131 RuleBase RU000601 SAAS SAAS018204
Sequence similarities	Belongs to the TrpA family. HAMAP-Rule MF_00131 RuleBase RU003662

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis HAMAP-Rule MF_00131 RuleBase RU000601 SAAS SAAS018204
Molecular function	Lyase HAMAP-Rule MF_00131 RuleBase RU000601 SAAS SAAS018204 EMBL AEF54644.1
Technical term	Complete proteome
Gene Ontology (GO)
Molecular_function	tryptophan synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	49	1	Proton acceptor By similarity HAMAP-Rule MF_00131
	Active site	60	1	Proton acceptor By similarity HAMAP-Rule MF_00131

Sequences

	Sequence		Length	Mass (Da)
	F6CZA7 [UniParc]. Last modified July 27, 2011. Version 1. Checksum: BDC68EB7FECA5627	FASTA	268	28,734
	10 20 30 40 50 60 MSRIKQCFEN LEKSGKKALI PYITAGDPSP KHTVTMMNAL VDAGADVIEI GMPFSDPMAD 70 80 90 100 110 120 GPVIQLACER SLAAGTSVRK VLEIIAEFRQ GNSTTPVVLM GYLNPIEFFG YQEFADAAKE 130 140 150 160 170 180 AGVDGVLLVD LTPEEATDVV ECFRQNEIDL IYLLSPTTTL ERAKKICALA SGYVYYVSVK 190 200 210 220 230 240 GVTGSSELDV DSVKQHVETL RSVTSLPIGV GFGIRDAKTA AAVSRCSDGV IVGSVLVNCI 250 260 AENKDQQKEY IADALGAILT PMRSEMDA

References

[1]

"Complete sequence of Marinomonas posidonica IVIA-Po-181." US DOE Joint Genome Institute Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Mikhailova N., Lu M., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Lucas-Elio P., Johnston A., Sanchez-Amat A., Woyke T. Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CECT 7376 / NCIMB 14433 / IVIA-Po-181.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP002771 Genomic DNA. Translation: AEF54644.1.
RefSeq	YP_004481563.1. NC_015559.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AEF54644; AEF54644; Mar181_1605.
GeneID	10646459.
KEGG	mpc:Mar181_1605.
Organism-specific databases
CMR	Search...
Phylogenomic databases
KO	K01695.
Enzyme and pathway databases
BioCyc	MPOS491952:GI6N-1658-MONOMER.
UniPathway	UPA00035; UER00044.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
HAMAP	MF_00131. Trp_synth_alpha.
InterPro	IPR013785. Aldolase_TIM. IPR011060. RibuloseP-bd_barrel. IPR018204. Trp_synthase_alpha_AS. IPR002028. Trp_synthase_suA. [Graphical view]
Pfam	PF00290. Trp_syntA. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
TIGRFAMs	TIGR00262. trpA. 1 hit.
PROSITE	PS00167. TRP_SYNTHASE_ALPHA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

F6CZA7_MARPP

Accession

Primary (citable) accession number: F6CZA7

Entry history

Integrated into UniProtKB/TrEMBL:	July 27, 2011
Last sequence update:	July 27, 2011
Last modified:	April 3, 2013
This is version 13 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)