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F6CKT7

- F6CKT7_DESK7

UniProt

F6CKT7 - F6CKT7_DESK7

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Protein

Alanine racemase

Gene

Desku_1293

Organism
Desulfotomaculum kuznetsovii (strain DSM 6115 / VKM B-1805 / 17)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei43 – 431Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei141 – 1411SubstrateUniRule annotation
Active sitei270 – 2701Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei318 – 3181Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciDKUZ760568:GHV4-1323-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Desku_1293Imported
OrganismiDesulfotomaculum kuznetsovii (strain DSM 6115 / VKM B-1805 / 17)Imported
Taxonomic identifieri760568 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfotomaculum
ProteomesiUP000009229: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei43 – 431N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliF6CKT7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.
OMAiEVIRVGT.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F6CKT7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MITESCSNGR PVWVEVNLGA VARNVREIRK LLQPGTKLMA VVKADAYGHG
60 70 80 90 100
ALPVARAALA NGAECLAVAI LDEALALRRG GITAPILILG YTPPEQASFL
110 120 130 140 150
VEYDLTQTVF SLDAVQAISA AAAAAGKTAR VHIKVDTGMG RIGVFPSEAP
160 170 180 190 200
DFAEAVSRLP NIFIEGVYTH MACADEQDKA YTRWQFDRFK EAVAGIEARG
210 220 230 240 250
VAIPLKHVAN SATTLDLPEM HLDMVRTGII LYGLWPSPDV RRVIDLKPAM
260 270 280 290 300
QLKTRVAYVK QVPAGTSISY GRTFTTTGPS VIATLPLGYA DGWSRLLSNK
310 320 330 340 350
AEVLIHGQRA PLVGRVCMDQ CMVDVTRIPG VRPGDEVVLF GVQGEQFLPV
360 370
EEVASHMGTI NYEMVCLISK RVPRIYLND
Length:379
Mass (Da):40,992
Last modified:July 27, 2011 - v1
Checksum:iDB23E04E25293590
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002770 Genomic DNA. Translation: AEG14876.1.
RefSeqiWP_013822391.1. NC_015573.1.
YP_004516677.1. NC_015573.1.

Genome annotation databases

EnsemblBacteriaiAEG14876; AEG14876; Desku_1293.
GeneIDi10665172.
KEGGidku:Desku_1293.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002770 Genomic DNA. Translation: AEG14876.1 .
RefSeqi WP_013822391.1. NC_015573.1.
YP_004516677.1. NC_015573.1.

3D structure databases

ProteinModelPortali F6CKT7.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEG14876 ; AEG14876 ; Desku_1293 .
GeneIDi 10665172.
KEGGi dku:Desku_1293.

Phylogenomic databases

KOi K01775.
OMAi EVIRVGT.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci DKUZ760568:GHV4-1323-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Desulfotomaculum kuznetsovii DSM 6115."
    Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Mikhailova N., Lu M., Saunders E., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Nazina T.
    , Ivanova A., Parshina S., Kuever J., Muyzer G., Plugge C., Stams A., Woyke T.
    Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 6115 / VKM B-1805 / 17Imported.

Entry informationi

Entry nameiF6CKT7_DESK7
AccessioniPrimary (citable) accession number: F6CKT7
Entry historyi
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3