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F6CKT7

- F6CKT7_DESK7

UniProt

F6CKT7 - F6CKT7_DESK7

Protein

Alanine racemase

Gene

Desku_1293

Organism
Desulfotomaculum kuznetsovii (strain DSM 6115 / VKM B-1805 / 17)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 23 (01 Oct 2014)
      Sequence version 1 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei43 – 431Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei141 – 1411SubstrateUniRule annotation
    Active sitei270 – 2701Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei318 – 3181Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciDKUZ760568:GHV4-1323-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:Desku_1293Imported
    OrganismiDesulfotomaculum kuznetsovii (strain DSM 6115 / VKM B-1805 / 17)Imported
    Taxonomic identifieri760568 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfotomaculum
    ProteomesiUP000009229: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei43 – 431N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliF6CKT7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    KOiK01775.
    OMAiEVIRVGT.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F6CKT7-1 [UniParc]FASTAAdd to Basket

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    MITESCSNGR PVWVEVNLGA VARNVREIRK LLQPGTKLMA VVKADAYGHG    50
    ALPVARAALA NGAECLAVAI LDEALALRRG GITAPILILG YTPPEQASFL 100
    VEYDLTQTVF SLDAVQAISA AAAAAGKTAR VHIKVDTGMG RIGVFPSEAP 150
    DFAEAVSRLP NIFIEGVYTH MACADEQDKA YTRWQFDRFK EAVAGIEARG 200
    VAIPLKHVAN SATTLDLPEM HLDMVRTGII LYGLWPSPDV RRVIDLKPAM 250
    QLKTRVAYVK QVPAGTSISY GRTFTTTGPS VIATLPLGYA DGWSRLLSNK 300
    AEVLIHGQRA PLVGRVCMDQ CMVDVTRIPG VRPGDEVVLF GVQGEQFLPV 350
    EEVASHMGTI NYEMVCLISK RVPRIYLND 379
    Length:379
    Mass (Da):40,992
    Last modified:July 27, 2011 - v1
    Checksum:iDB23E04E25293590
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002770 Genomic DNA. Translation: AEG14876.1.
    RefSeqiYP_004516677.1. NC_015573.1.

    Genome annotation databases

    EnsemblBacteriaiAEG14876; AEG14876; Desku_1293.
    GeneIDi10665172.
    KEGGidku:Desku_1293.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002770 Genomic DNA. Translation: AEG14876.1 .
    RefSeqi YP_004516677.1. NC_015573.1.

    3D structure databases

    ProteinModelPortali F6CKT7.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEG14876 ; AEG14876 ; Desku_1293 .
    GeneIDi 10665172.
    KEGGi dku:Desku_1293.

    Phylogenomic databases

    KOi K01775.
    OMAi EVIRVGT.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci DKUZ760568:GHV4-1323-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Desulfotomaculum kuznetsovii DSM 6115."
      Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Mikhailova N., Lu M., Saunders E., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Nazina T.
      , Ivanova A., Parshina S., Kuever J., Muyzer G., Plugge C., Stams A., Woyke T.
      Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 6115 / VKM B-1805 / 17Imported.

    Entry informationi

    Entry nameiF6CKT7_DESK7
    AccessioniPrimary (citable) accession number: F6CKT7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 27, 2011
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 23 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3