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F6CDF0 (F6CDF0_LACKZ) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase HAMAP-Rule MF_00049

EC=6.1.1.4 HAMAP-Rule MF_00049
Alternative name(s):
Leucyl-tRNA synthetase HAMAP-Rule MF_00049
Gene names
Name:leuS HAMAP-Rule MF_00049 EMBL AEG39859.1
Ordered Locus Names:WANG_0164 EMBL AEG39859.1
OrganismLactobacillus kefiranofaciens (strain ZW3) [Complete proteome] [HAMAP] EMBL AEG39859.1
Taxonomic identifier1033837 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length804 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family. HAMAP-Rule MF_00049 RuleBase RU003489

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Motif39 – 5012"HIGH" region By similarity HAMAP-Rule MF_00049
Motif573 – 5775"KMSKS" region By similarity HAMAP-Rule MF_00049

Sites

Binding site5761ATP By similarity HAMAP-Rule MF_00049

Sequences

Sequence LengthMass (Da)Tools
F6CDF0 [UniParc].

Last modified July 27, 2011. Version 1.
Checksum: 63378F2055D49460

FASTA80492,005
        10         20         30         40         50         60 
MYNHKVVEKK WQDYWAKHDT FKTGTDPKKK NYYALDMFPF PSGKGLHVGH PEGYTATDIV 

        70         80         90        100        110        120 
SRMKRAQGYN VLHPMGWDAF GLPTEQYALK TGMDPAVVTK QNIANFKEQL NKLGFSYDWD 

       130        140        150        160        170        180 
REITTSDPNY YKWTQWVFEQ MYENGLAYEA EVPVNWSPDL GTVVANEEVI DGKTERGGYP 

       190        200        210        220        230        240 
VYRKNMRQWM LKMTAYADRL LEDLDSLDWP EPVKEMQRNW IGRSVGAQVT FKIKGSDKTF 

       250        260        270        280        290        300 
DIFTTRPDTL FGCSYTVLAP ENKLVQEITT DGHRDEVNAY IKKIESKSDL ERTDLNKDKT 

       310        320        330        340        350        360 
GVFTGAYAIN PVNGKEVPIW ISDYVLASYG TGAVMAVPAH DDRDYAFATK FGLPINPVLK 

       370        380        390        400        410        420 
GGDISKAAFT EDGPHINSEF LDGLNIKDAK KKMVDWLEDH NCGKKKVNYK LRDWDFSRQR 

       430        440        450        460        470        480 
YWGEPIPVIH WEDGTTSLVP EDQLPLRLPH ATDIKPSGTP ESPLANLTDW VNVVDENGRK 

       490        500        510        520        530        540 
GKRETNTMPN WAGSSWYYLR YVDPHNDKEL ADYDLLKQWL PVDLYIGGAE HAVRHLLYAR 

       550        560        570        580        590        600 
FWHKVLYDLG VVPTKEPFQR LYNQGLILKN HEKMSKSKGN VVNPDDVIDE YGADSLRMYE 

       610        620        630        640        650        660 
MFMGPLDASI DWDDNGPAST KKFLDRVWRL FVNDLDLKAI PQERIVDKND GELDKVYAET 

       670        680        690        700        710        720 
VKKVTEDFDA LHFNTAISQM MVFINAAQKA KSIPREYAEG FVKLLAPVAP HMMEEIWQVF 

       730        740        750        760        770        780 
GHDESITYAK WPTYDPAKLV ESTVEIMVQV NGKLRGKFQA PKDADRDAVQ KQALAIEHVK 

       790        800 
KFLAGKDIKK VIVVPNKIVN IVAK 

« Hide

References

[1]"Complete genome sequence of Lactobacillus kefiranofaciens ZW3."
Wang Y., Wang J., Ahmed Z., Bai X., Wang J.
J. Bacteriol. 193:4280-4281(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ZW3 EMBL AEG39859.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002764 Genomic DNA. Translation: AEG39859.1.
RefSeqYP_004561961.1. NC_015602.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEG39859; AEG39859; WANG_0164.
GeneID10749647.
KEGGlke:WANG_0164.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01869.

Enzyme and pathway databases

BioCycLKEF1033837:GHZJ-196-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF6CDF0_LACKZ
AccessionPrimary (citable) accession number: F6CDF0
Entry history
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: June 11, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)