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F6CDF0

- F6CDF0_LACKZ

UniProt

F6CDF0 - F6CDF0_LACKZ

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Lactobacillus kefiranofaciens (strain ZW3)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 23 (01 Oct 2014)
      Sequence version 1 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei576 – 5761ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetaseUniRule annotationImported, Ligase

    Keywords - Biological processi

    Protein biosynthesisUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLKEF1033837:GHZJ-196-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Gene namesi
    Name:leuSUniRule annotationImported
    Ordered Locus Names:WANG_0164Imported
    OrganismiLactobacillus kefiranofaciens (strain ZW3)Imported
    Taxonomic identifieri1033837 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000009228: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi39 – 5012"HIGH" regionUniRule annotationAdd
    BLAST
    Motifi573 – 5775"KMSKS" regionUniRule annotation

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    KOiK01869.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F6CDF0-1 [UniParc]FASTAAdd to Basket

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    MYNHKVVEKK WQDYWAKHDT FKTGTDPKKK NYYALDMFPF PSGKGLHVGH    50
    PEGYTATDIV SRMKRAQGYN VLHPMGWDAF GLPTEQYALK TGMDPAVVTK 100
    QNIANFKEQL NKLGFSYDWD REITTSDPNY YKWTQWVFEQ MYENGLAYEA 150
    EVPVNWSPDL GTVVANEEVI DGKTERGGYP VYRKNMRQWM LKMTAYADRL 200
    LEDLDSLDWP EPVKEMQRNW IGRSVGAQVT FKIKGSDKTF DIFTTRPDTL 250
    FGCSYTVLAP ENKLVQEITT DGHRDEVNAY IKKIESKSDL ERTDLNKDKT 300
    GVFTGAYAIN PVNGKEVPIW ISDYVLASYG TGAVMAVPAH DDRDYAFATK 350
    FGLPINPVLK GGDISKAAFT EDGPHINSEF LDGLNIKDAK KKMVDWLEDH 400
    NCGKKKVNYK LRDWDFSRQR YWGEPIPVIH WEDGTTSLVP EDQLPLRLPH 450
    ATDIKPSGTP ESPLANLTDW VNVVDENGRK GKRETNTMPN WAGSSWYYLR 500
    YVDPHNDKEL ADYDLLKQWL PVDLYIGGAE HAVRHLLYAR FWHKVLYDLG 550
    VVPTKEPFQR LYNQGLILKN HEKMSKSKGN VVNPDDVIDE YGADSLRMYE 600
    MFMGPLDASI DWDDNGPAST KKFLDRVWRL FVNDLDLKAI PQERIVDKND 650
    GELDKVYAET VKKVTEDFDA LHFNTAISQM MVFINAAQKA KSIPREYAEG 700
    FVKLLAPVAP HMMEEIWQVF GHDESITYAK WPTYDPAKLV ESTVEIMVQV 750
    NGKLRGKFQA PKDADRDAVQ KQALAIEHVK KFLAGKDIKK VIVVPNKIVN 800
    IVAK 804
    Length:804
    Mass (Da):92,005
    Last modified:July 27, 2011 - v1
    Checksum:i63378F2055D49460
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002764 Genomic DNA. Translation: AEG39859.1.
    RefSeqiYP_004561961.1. NC_015602.1.

    Genome annotation databases

    EnsemblBacteriaiAEG39859; AEG39859; WANG_0164.
    GeneIDi10749647.
    KEGGilke:WANG_0164.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002764 Genomic DNA. Translation: AEG39859.1 .
    RefSeqi YP_004561961.1. NC_015602.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEG39859 ; AEG39859 ; WANG_0164 .
    GeneIDi 10749647.
    KEGGi lke:WANG_0164.

    Phylogenomic databases

    KOi K01869.

    Enzyme and pathway databases

    BioCyci LKEF1033837:GHZJ-196-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Lactobacillus kefiranofaciens ZW3."
      Wang Y., Wang J., Ahmed Z., Bai X., Wang J.
      J. Bacteriol. 193:4280-4281(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ZW3Imported.

    Entry informationi

    Entry nameiF6CDF0_LACKZ
    AccessioniPrimary (citable) accession number: F6CDF0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 27, 2011
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 23 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3