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F6CDF0

- F6CDF0_LACKZ

UniProt

F6CDF0 - F6CDF0_LACKZ

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Protein
Leucine--tRNA ligase
Gene
leuS, WANG_0164
Organism
Lactobacillus kefiranofaciens (strain ZW3)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei576 – 5761ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetaseUniRule annotationImported, Ligase

Keywords - Biological processi

Protein biosynthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciLKEF1033837:GHZJ-196-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetase
Gene namesi
Name:leuSUniRule annotationImported
Ordered Locus Names:WANG_0164Imported
OrganismiLactobacillus kefiranofaciens (strain ZW3)Imported
Taxonomic identifieri1033837 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000009228: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi39 – 5012"HIGH" region By similarityUniRule annotation
Add
BLAST
Motifi573 – 5775"KMSKS" region By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK01869.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F6CDF0-1 [UniParc]FASTAAdd to Basket

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MYNHKVVEKK WQDYWAKHDT FKTGTDPKKK NYYALDMFPF PSGKGLHVGH    50
PEGYTATDIV SRMKRAQGYN VLHPMGWDAF GLPTEQYALK TGMDPAVVTK 100
QNIANFKEQL NKLGFSYDWD REITTSDPNY YKWTQWVFEQ MYENGLAYEA 150
EVPVNWSPDL GTVVANEEVI DGKTERGGYP VYRKNMRQWM LKMTAYADRL 200
LEDLDSLDWP EPVKEMQRNW IGRSVGAQVT FKIKGSDKTF DIFTTRPDTL 250
FGCSYTVLAP ENKLVQEITT DGHRDEVNAY IKKIESKSDL ERTDLNKDKT 300
GVFTGAYAIN PVNGKEVPIW ISDYVLASYG TGAVMAVPAH DDRDYAFATK 350
FGLPINPVLK GGDISKAAFT EDGPHINSEF LDGLNIKDAK KKMVDWLEDH 400
NCGKKKVNYK LRDWDFSRQR YWGEPIPVIH WEDGTTSLVP EDQLPLRLPH 450
ATDIKPSGTP ESPLANLTDW VNVVDENGRK GKRETNTMPN WAGSSWYYLR 500
YVDPHNDKEL ADYDLLKQWL PVDLYIGGAE HAVRHLLYAR FWHKVLYDLG 550
VVPTKEPFQR LYNQGLILKN HEKMSKSKGN VVNPDDVIDE YGADSLRMYE 600
MFMGPLDASI DWDDNGPAST KKFLDRVWRL FVNDLDLKAI PQERIVDKND 650
GELDKVYAET VKKVTEDFDA LHFNTAISQM MVFINAAQKA KSIPREYAEG 700
FVKLLAPVAP HMMEEIWQVF GHDESITYAK WPTYDPAKLV ESTVEIMVQV 750
NGKLRGKFQA PKDADRDAVQ KQALAIEHVK KFLAGKDIKK VIVVPNKIVN 800
IVAK 804
Length:804
Mass (Da):92,005
Last modified:July 27, 2011 - v1
Checksum:i63378F2055D49460
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002764 Genomic DNA. Translation: AEG39859.1.
RefSeqiYP_004561961.1. NC_015602.1.

Genome annotation databases

EnsemblBacteriaiAEG39859; AEG39859; WANG_0164.
GeneIDi10749647.
KEGGilke:WANG_0164.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002764 Genomic DNA. Translation: AEG39859.1 .
RefSeqi YP_004561961.1. NC_015602.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEG39859 ; AEG39859 ; WANG_0164 .
GeneIDi 10749647.
KEGGi lke:WANG_0164.

Phylogenomic databases

KOi K01869.

Enzyme and pathway databases

BioCyci LKEF1033837:GHZJ-196-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Lactobacillus kefiranofaciens ZW3."
    Wang Y., Wang J., Ahmed Z., Bai X., Wang J.
    J. Bacteriol. 193:4280-4281(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ZW3Imported.

Entry informationi

Entry nameiF6CDF0_LACKZ
AccessioniPrimary (citable) accession number: F6CDF0
Entry historyi
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: June 11, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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