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Protein

Phosphoribosylamine--glycine ligase

Gene

purD

Organism
Methanotorris igneus (strain DSM 5666 / JCM 11834 / Kol 5)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N1-(5-phospho-D-ribosyl)glycinamide.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Amidophosphoribosyltransferase (purF)
  2. Phosphoribosylamine--glycine ligase (purD)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processPurine biosynthesisUniRule annotation
LigandATP-bindingPROSITE-ProRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMIGN880724:G1GY0-36-MONOMER.
UniPathwayiUPA00074; UER00125.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylamine--glycine ligaseUniRule annotation (EC:6.3.4.13UniRule annotation)
Alternative name(s):
GARSUniRule annotation
Glycinamide ribonucleotide synthetaseUniRule annotation
Phosphoribosylglycinamide synthetaseUniRule annotation
Gene namesi
Name:purDUniRule annotation
Ordered Locus Names:Metig_0035Imported
OrganismiMethanotorris igneus (strain DSM 5666 / JCM 11834 / Kol 5)Imported
Taxonomic identifieri880724 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanotorris
Proteomesi
  • UP000009227 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi880724.Metig_0035.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini109 – 324ATP-graspInterPro annotationAdd BLAST216

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili251 – 271Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the GARS family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiarCOG04415. Archaea.
COG0151. LUCA.
KOiK01945.
OMAiKATVCKY.
OrthoDBiPOG093Z02WG.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.90.600.10. 1 hit.
HAMAPiMF_00138. GARS. 1 hit.
InterProiView protein in InterPro
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR016185. PreATP-grasp_dom_sf.
IPR020561. PRibGlycinamid_synth_ATP-grasp.
IPR000115. PRibGlycinamide_synth.
IPR020560. PRibGlycinamide_synth_C-dom.
IPR037123. PRibGlycinamide_synth_C_sf.
IPR020559. PRibGlycinamide_synth_CS.
IPR020562. PRibGlycinamide_synth_N.
IPR011054. Rudment_hybrid_motif.
PfamiView protein in Pfam
PF01071. GARS_A. 1 hit.
PF02843. GARS_C. 1 hit.
PF02844. GARS_N. 1 hit.
SMARTiView protein in SMART
SM01210. GARS_C. 1 hit.
SUPFAMiSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR00877. purD. 1 hit.
PROSITEiView protein in PROSITE
PS50975. ATP_GRASP. 1 hit.
PS00184. GARS. 1 hit.

Sequencei

Sequence statusi: Complete.

F6BE60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKILLIGGGA RESAIAHALK KNADVKLYTL MNNKNPGIAR LSEKISLNKE
60 70 80 90 100
TDLDAVKAFA EEVKPDMAVI GPEAPLGAGV ADLLWDMGIP TVGPKKLPAQ
110 120 130 140 150
IETSKEFMRN LFKKYNIKGS LQYKAFEEYG EELEAFIDEM TNQGKDVVVK
160 170 180 190 200
PVGLTGGKGV KVVGEQLKDN EEAKQYAKEV FEKNIGGGKV IIEERLIGVE
210 220 230 240 250
FTLHGFVDGD TIKFTPAVQD HPHAYENDEG PITGGMGSYS CPDLSLPFLT
260 270 280 290 300
ENDLKDAKEI MEDTVKALKK EVGDYQGFLY GQFMLTADGP KIIEYNARFG
310 320 330 340 350
DPEAMNILAI LKNDFVEVCE AIANKKLKDI DVKFENKATV CKYVVPNGYP
360 370 380 390 400
TNPVRNKEIF VDEEKIKETG AILHYASVNE VDGKLYMTGS RSVAVVGVAD
410 420 430 440
TIEEAEKIAE SAIQYIKGDV FHRSDVGKLD LIKKRIERMK ELRENK
Length:446
Mass (Da):49,320
Last modified:July 27, 2011 - v1
Checksum:i5304034ADFA3A08D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002737 Genomic DNA. Translation: AEF95596.1.
RefSeqiWP_013798205.1. NC_015562.1.

Genome annotation databases

EnsemblBacteriaiAEF95596; AEF95596; Metig_0035.
GeneIDi10642870.
KEGGimig:Metig_0035.

Similar proteinsi

Entry informationi

Entry nameiF6BE60_METIK
AccessioniPrimary (citable) accession number: F6BE60
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: February 28, 2018
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported