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F6BB32

- HPRT_METIK

UniProt

F6BB32 - HPRT_METIK

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Protein

Hypoxanthine/guanine phosphoribosyltransferase

Gene
hpt, Metig_0361
Organism
Methanotorris igneus (strain DSM 5666 / JCM 11834 / Kol 5)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis By similarity.UniRule annotation

Catalytic activityi

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. guanine phosphoribosyltransferase activity Source: UniProtKB-EC
  2. hypoxanthine phosphoribosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. IMP salvage Source: UniProtKB-UniPathway
  2. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

BioCyciMIGN880724:GIW6-363-MONOMER.
UniPathwayiUPA00591; UER00648.

Names & Taxonomyi

Protein namesi
Recommended name:
Hypoxanthine/guanine phosphoribosyltransferase (EC:2.4.2.8)
Short name:
HGPRTase
Gene namesi
Name:hpt
Ordered Locus Names:Metig_0361
OrganismiMethanotorris igneus (strain DSM 5666 / JCM 11834 / Kol 5)
Taxonomic identifieri880724 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanotorris
ProteomesiUP000009227: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 183183Hypoxanthine/guanine phosphoribosyltransferaseUniRule annotationPRO_0000415487Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliF6BB32.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK00759.
OMAiMIAIINA.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01467. Hypx_phosphoribosyltr.
InterProiIPR026597. HGPRTase-like.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F6BB32-1 [UniParc]FASTAAdd to Basket

« Hide

MLLEETLKSC PTVKRGDYEY FIHPISDGVP IVNPKLLREV ATRIIKEVDF    50
ENIDKIVTAE AMGIPLVTTL SLYTDVPYVI MRKREYKLKG EIPVHQETGY 100
SKGQLYLNGI EKGDRVLIVD DVISTGGTMI AIINALKKAG AEIKDIVCVI 150
ERGEGKKIVE EKTGYKIKTL VKLDVKDGKV VIL 183
Length:183
Mass (Da):20,417
Last modified:July 27, 2011 - v1
Checksum:i9E0CCCCABC9694A1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002737 Genomic DNA. Translation: AEF95917.1.
RefSeqiYP_004483982.1. NC_015562.1.

Genome annotation databases

EnsemblBacteriaiAEF95917; AEF95917; Metig_0361.
GeneIDi10643198.
KEGGimig:Metig_0361.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002737 Genomic DNA. Translation: AEF95917.1 .
RefSeqi YP_004483982.1. NC_015562.1.

3D structure databases

ProteinModelPortali F6BB32.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEF95917 ; AEF95917 ; Metig_0361 .
GeneIDi 10643198.
KEGGi mig:Metig_0361.

Phylogenomic databases

KOi K00759.
OMAi MIAIINA.

Enzyme and pathway databases

UniPathwayi UPA00591 ; UER00648 .
BioCyci MIGN880724:GIW6-363-MONOMER.

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
HAMAPi MF_01467. Hypx_phosphoribosyltr.
InterProi IPR026597. HGPRTase-like.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view ]
Pfami PF00156. Pribosyltran. 1 hit.
[Graphical view ]
SUPFAMi SSF53271. SSF53271. 1 hit.
PROSITEi PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 5666 / JCM 11834 / Kol 5.

Entry informationi

Entry nameiHPRT_METIK
AccessioniPrimary (citable) accession number: F6BB32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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