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F6BB32

- HPRT_METIK

UniProt

F6BB32 - HPRT_METIK

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Protein

Hypoxanthine/guanine phosphoribosyltransferase

Gene

hpt

Organism
Methanotorris igneus (strain DSM 5666 / JCM 11834 / Kol 5)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.UniRule annotation

Catalytic activityi

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. guanine phosphoribosyltransferase activity Source: UniProtKB-EC
  2. hypoxanthine phosphoribosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. IMP salvage Source: UniProtKB-UniPathway
  2. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

BioCyciMIGN880724:GIW6-363-MONOMER.
UniPathwayiUPA00591; UER00648.

Names & Taxonomyi

Protein namesi
Recommended name:
Hypoxanthine/guanine phosphoribosyltransferaseUniRule annotation (EC:2.4.2.8UniRule annotation)
Short name:
HGPRTaseUniRule annotation
Gene namesi
Name:hptUniRule annotation
Ordered Locus Names:Metig_0361
OrganismiMethanotorris igneus (strain DSM 5666 / JCM 11834 / Kol 5)
Taxonomic identifieri880724 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanotorris
ProteomesiUP000009227: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 183183Hypoxanthine/guanine phosphoribosyltransferasePRO_0000415487Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliF6BB32.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.UniRule annotation

Phylogenomic databases

KOiK00759.
OMAiMIAIINA.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01467. Hypx_phosphoribosyltr.
InterProiIPR026597. HGPRTase-like.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F6BB32-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLLEETLKSC PTVKRGDYEY FIHPISDGVP IVNPKLLREV ATRIIKEVDF
60 70 80 90 100
ENIDKIVTAE AMGIPLVTTL SLYTDVPYVI MRKREYKLKG EIPVHQETGY
110 120 130 140 150
SKGQLYLNGI EKGDRVLIVD DVISTGGTMI AIINALKKAG AEIKDIVCVI
160 170 180
ERGEGKKIVE EKTGYKIKTL VKLDVKDGKV VIL
Length:183
Mass (Da):20,417
Last modified:July 27, 2011 - v1
Checksum:i9E0CCCCABC9694A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002737 Genomic DNA. Translation: AEF95917.1.
RefSeqiYP_004483982.1. NC_015562.1.

Genome annotation databases

EnsemblBacteriaiAEF95917; AEF95917; Metig_0361.
GeneIDi10643198.
KEGGimig:Metig_0361.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002737 Genomic DNA. Translation: AEF95917.1 .
RefSeqi YP_004483982.1. NC_015562.1.

3D structure databases

ProteinModelPortali F6BB32.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEF95917 ; AEF95917 ; Metig_0361 .
GeneIDi 10643198.
KEGGi mig:Metig_0361.

Phylogenomic databases

KOi K00759.
OMAi MIAIINA.

Enzyme and pathway databases

UniPathwayi UPA00591 ; UER00648 .
BioCyci MIGN880724:GIW6-363-MONOMER.

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
HAMAPi MF_01467. Hypx_phosphoribosyltr.
InterProi IPR026597. HGPRTase-like.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view ]
Pfami PF00156. Pribosyltran. 1 hit.
[Graphical view ]
SUPFAMi SSF53271. SSF53271. 1 hit.
PROSITEi PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 5666 / JCM 11834 / Kol 5.

Entry informationi

Entry nameiHPRT_METIK
AccessioniPrimary (citable) accession number: F6BB32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3