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F6B467 (F6B467_DESCC) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 15. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Carbamoyl-phosphate synthase small chain HAMAP-Rule MF_01209
EC=6.3.5.5 HAMAP-Rule MF_01209
Alternative name(s):
Carbamoyl-phosphate synthetase glutamine chain HAMAP-Rule MF_01209
Gene names
Name:carA HAMAP-Rule MF_01209
Ordered Locus Names:Desca_1263
OrganismDesulfotomaculum carboxydivorans (strain DSM 14880 / VKM B-2319 / CO-1-SRB) [Complete proteome] [HAMAP] EMBL AEF94122.1
Taxonomic identifier868595 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Peptococcaceae › Desulfotomaculum ›

Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2 ATP + L-glutamine + HCO3- + H2O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate. HAMAP-Rule MF_01209

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1. HAMAP-Rule MF_01209

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3. HAMAP-Rule MF_01209 SAAS SAAS006274

Subunit structure

Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate By similarity. HAMAP-Rule MF_01209

Sequence similarities

Belongs to the CarA family. HAMAP-Rule MF_01209

Contains 1 glutamine amidotransferase type-1 domain. HAMAP-Rule MF_01209

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain173 – 354182Glutamine amidotransferase type-1 By similarity HAMAP-Rule MF_01209
Region1 – 173173CPSase By similarity HAMAP-Rule MF_01209

Sites

Active site2481Nucleophile By similarity HAMAP-Rule MF_01209
Active site3321 By similarity HAMAP-Rule MF_01209
Active site3341 By similarity HAMAP-Rule MF_01209

Sequences

Sequence LengthMass (Da)Tools
F6B467 [UniParc].

Last modified July 27, 2011. Version 1.
Checksum: 5D0391F5D82C569B

FASTA35438,530
        10         20         30         40         50         60 
MQAVLVLEDG SVFYGKAFGA TGEQWGEVVF NTGMTGYQEV LTDPSYCGQI VVMTYPLIGN 

        70         80         90        100        110        120 
YGINKDDFEA KKSFVRGFVV KEECHRPSNW RVSNKIDEFL AREGVIGISG IDTRALTRRI 

       130        140        150        160        170        180 
RNHGTMRGII SSAATDIQTL IDKARSCPQI TGQELVPTVA TKEIYTVPGN GPRVVLMDFG 

       190        200        210        220        230        240 
AKANIVRCLN QRGCEVVVVP PTTTPEEIMT LGPQGVMLSN GPGDPTDVPY AIKTVSNLIG 

       250        260        270        280        290        300 
QLPIFGICLG HQIIGLAVGG KTYKLKFGHR GANHPVKDLA TGRVFITSQN HGFAVDRQSL 

       310        320        330        340        350 
PPDVEVSHIN LNDNTVEGLR HKSLPVFSVQ YHPEAAPGPM DSEYLFDQFL ANLS

« Hide

References

[1]"Complete sequence of Desulfotomaculum carboxydivorans CO-1-SRB."
Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Mikhailova N., Lu M., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Stams A., Plugge C. expand/collapse author list , Muyzer G., Kuever J., Parshina S., Ivanova A., Nazina T., Woyke T.
Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 14880 / VKM B-2319 / CO-1-SRB.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002736 Genomic DNA. Translation: AEF94122.1.
RefSeqYP_004497034.1. NC_015565.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEF94122; AEF94122; Desca_1263.
GeneID10630663.
KEGGdca:Desca_1263.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01956.

Enzyme and pathway databases

BioCycDCAR868595:GHXC-1320-MONOMER.
UniPathwayUPA00068; UER00171.
UPA00070; UER00115.

Family and domain databases

Gene3D3.50.30.20. 1 hit.
HAMAPMF_01209. CPSase_S_chain.
InterProIPR006274. CarbamoylP_synth_ssu.
IPR002474. CarbamoylP_synth_ssu_N.
IPR017926. GATASE_1.
[Graphical view]
PfamPF00988. CPSase_sm_chain. 1 hit.
PF00117. GATase. 1 hit.
[Graphical view]
SMARTSM01097. CPSase_sm_chain. 1 hit.
[Graphical view]
SUPFAMSSF52021. CP_synthsmall. 1 hit.
TIGRFAMsTIGR01368. CPSaseIIsmall. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF6B467_DESCC
AccessionPrimary (citable) accession number: F6B467
Entry history
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: April 3, 2013
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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