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Protein
Submitted name:

Isocitrate dehydrogenase, NADP-dependent

Gene

Psefu_2325

Organism
Pseudomonas fulva (strain 12-X)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei146 – 1461SubstrateUniRule annotation
Sitei256 – 2561Critical for catalysisUniRule annotation
Metal bindingi351 – 3511Magnesium or manganeseUniRule annotation
Sitei421 – 4211Critical for catalysisUniRule annotation
Binding sitei548 – 5481SubstrateUniRule annotation
Metal bindingi549 – 5491Magnesium or manganeseUniRule annotation
Metal bindingi553 – 5531Magnesium or manganeseUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciPFUL743720:GHQV-2358-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase, NADP-dependentImported (EC:1.1.1.42Imported)
Gene namesi
Ordered Locus Names:Psefu_2325Imported
OrganismiPseudomonas fulva (strain 12-X)Imported
Taxonomic identifieri743720 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000686 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi743720.Psefu_2325.

Structurei

3D structure databases

ProteinModelPortaliF6ACB0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni133 – 1408Substrate bindingUniRule annotation

Phylogenomic databases

KOiK00031.
OMAiRDSGKMW.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

F6ACB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTRSKIIYT LTDEAPALAT YSLLPIVKAF TASSDIAVET RDISLAGRIL
60 70 80 90 100
ALFPEFLTDA QKQGDHLAEL GALATTPEAN IIKLPNISAS VPQLKAAIKE
110 120 130 140 150
LQSQGYALPD YPDADDSEQA RDIRSRYDKV KGSAVNPVLR EGNSDRRAPL
160 170 180 190 200
SVKNYARKHP HKMGAWAADS KSHVAHMESG DFYGSEKAAL IDAKGSVKIE
210 220 230 240 250
LIGADGSTTV LKEKTSVLAD EVLDCSVMSK KALRSFIAAQ IEDAKKQGVL
260 270 280 290 300
FSVHLKATMM KVSDPIIFGQ IVAEFYKPAL EKHAAALQEA GFNLNNGIGD
310 320 330 340 350
LYASIKKLPA DKQAEIEADI NAVYADRPAL AMVNSDKGIT NLHVPSDVIV
360 370 380 390 400
DASMPAMIRD SGRMWNTAGE LQDAKAVIPD RCYAGIYQAV IEDCKANGAF
410 420 430 440 450
NPTTMGSVPN VGLMAQKAEE YGSHDKTFQI QAAGVVRVSD ANGKVLMEQK
460 470 480 490 500
VEEGDIFRMC QTKDAPIQDW VKLAVNRARL SNTPAVFWLD PARAHDAEMI
510 520 530 540 550
KKVEKYLKDH DTSGLDIRIL APVDAIKFSL ARIREGKDTI SVTGNVLRDY
560 570 580 590 600
LTDLFPIMEL GTSAKMLSIV PLMNGGGLFE TGAGGSAPKH VQQLVEENFL
610 620 630 640 650
RWDSLGEFLA LAASLEHLGN TYDNPKALVL SKTLDQATGQ FLDNDKSPAR
660 670 680 690 700
KVGGIDNRGS HFYLALYWAQ ALAAQSEDAA LKAQFAPLAK TLTDNEAKIV
710 720 730 740
AELGAVQGKP ADIGGYYAPN KELTEKVMRP SATLNAALAS LA
Length:742
Mass (Da):80,113
Last modified:July 27, 2011 - v1
Checksum:iD1EDD95F98694A49
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002727 Genomic DNA. Translation: AEF22292.1.
RefSeqiWP_013791421.1. NC_015556.1.

Genome annotation databases

EnsemblBacteriaiAEF22292; AEF22292; Psefu_2325.
KEGGipfv:Psefu_2325.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002727 Genomic DNA. Translation: AEF22292.1.
RefSeqiWP_013791421.1. NC_015556.1.

3D structure databases

ProteinModelPortaliF6ACB0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi743720.Psefu_2325.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEF22292; AEF22292; Psefu_2325.
KEGGipfv:Psefu_2325.

Phylogenomic databases

KOiK00031.
OMAiRDSGKMW.

Enzyme and pathway databases

BioCyciPFUL743720:GHQV-2358-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 12-XImported.

Entry informationi

Entry nameiF6ACB0_PSEF1
AccessioniPrimary (citable) accession number: F6ACB0
Entry historyi
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: July 22, 2015
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.