UniProtKB - F6A8G7 (F6A8G7_PSEF1)
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Protein
3-isopropylmalate dehydratase small subunit
Gene
leuD
Organism
Pseudomonas fulva (strain 12-X)
Status
Functioni
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.UniRule annotationSAAS annotation
Catalytic activityi
(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate.UniRule annotationSAAS annotation
: L-leucine biosynthesis Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes L-leucine from 3-methyl-2-oxobutanoate.UniRule annotationSAAS annotationProteins known to be involved in the 4 steps of the subpathway in this organism are:
- 2-isopropylmalate synthase (leuA), 2-isopropylmalate synthase (leuA)
- 3-isopropylmalate dehydratase large subunit (leuC), 3-isopropylmalate dehydratase small subunit (leuD), 3-isopropylmalate dehydratase small subunit (leuD), 3-isopropylmalate dehydratase large subunit (leuC)
- 3-isopropylmalate dehydrogenase (leuB)
- Branched-chain-amino-acid aminotransferase (Psefu_1539)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-leucine from 3-methyl-2-oxobutanoate, the pathway L-leucine biosynthesis and in Amino-acid biosynthesis.
GO - Molecular functioni
- 3-isopropylmalate dehydratase activity Source: UniProtKB-UniRule
GO - Biological processi
- leucine biosynthetic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | LyaseUniRule annotationSAAS annotation |
Biological process | Amino-acid biosynthesis, Branched-chain amino acid biosynthesis, Leucine biosynthesisUniRule annotationSAAS annotation |
Enzyme and pathway databases
BioCyci | PFUL743720:G1GXN-3103-MONOMER. |
UniPathwayi | UPA00048; UER00071. |
Names & Taxonomyi
Protein namesi | Recommended name: 3-isopropylmalate dehydratase small subunitUniRule annotation (EC:4.2.1.33UniRule annotation)Alternative name(s): Alpha-IPM isomeraseUniRule annotation Short name: IPMIUniRule annotation Isopropylmalate isomeraseUniRule annotation |
Gene namesi | Name:leuDUniRule annotation Ordered Locus Names:Psefu_3074Imported |
Organismi | Pseudomonas fulva (strain 12-X)Imported |
Taxonomic identifieri | 743720 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas › |
Proteomesi |
|
Subcellular locationi
GO - Cellular componenti
- 3-isopropylmalate dehydratase complex Source: InterPro
Interactioni
Subunit structurei
Heterodimer of LeuC and LeuD.UniRule annotationSAAS annotation
Protein-protein interaction databases
STRINGi | 743720.Psefu_3074. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 132 | Aconitase_CInterPro annotationAdd BLAST | 132 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG4105MQS. Bacteria. COG0066. LUCA. |
KOi | K01704. |
OMAi | AFTTHTG. |
OrthoDBi | POG091H02FJ. |
Family and domain databases
CDDi | cd01577. IPMI_Swivel. 1 hit. |
Gene3Di | 3.20.19.10. 1 hit. |
HAMAPi | MF_01031. LeuD_type1. 1 hit. |
InterProi | View protein in InterPro IPR004431. 3-IsopropMal_deHydase_ssu. IPR015928. Aconitase/3IPM_dehydase_swvl. IPR000573. AconitaseA/IPMdHydase_ssu_swvl. IPR033940. IPMI_Swivel. |
Pfami | View protein in Pfam PF00694. Aconitase_C. 1 hit. |
TIGRFAMsi | TIGR00171. leuD. 1 hit. |
i Sequence
Sequence statusi: Complete.
F6A8G7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKAFTQHTGL VCPLDRANVD TDQIIPKQFL KSIKRTGFGP NLFDEWRYLD
60 70 80 90 100
VGQPNQDNSK RPINKDFVLN FPRYQGASVL LARENFGCGS SREHAPWALD
110 120 130 140 150
EYGFRTVIAP SFADIFFNNS FKNGLLPIIL KAEEVDALFE QAEASEGYQL
160 170 180 190 200
TVDLEAQTVT RPDGVQYSFE VDAFRKHCLL NGLDDIGLTL QDAEAIRAFE
210
VGYQQRQPWL FGAVK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP002727 Genomic DNA. Translation: AEF23038.1. |
RefSeqi | WP_013792165.1. NC_015556.1. |
Genome annotation databases
EnsemblBacteriai | AEF23038; AEF23038; Psefu_3074. |
GeneIDi | 31810842. |
KEGGi | pfv:Psefu_3074. |
Similar proteinsi
Entry informationi
Entry namei | F6A8G7_PSEF1 | |
Accessioni | F6A8G7Primary (citable) accession number: F6A8G7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | July 27, 2011 | |
Last modified: | February 28, 2018 | |
This is version 46 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |