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UniProtKB - F6A8G7 (F6A8G7_PSEF1)

UniProt

F6A8G7 - F6A8G7_PSEF1

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Protein

3-isopropylmalate dehydratase small subunit

Gene

leuD

Organism
Pseudomonas fulva (strain 12-X)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.UniRule annotationSAAS annotation

Catalytic activityi

(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate.UniRule annotationSAAS annotation

Pathwayi: L-leucine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-leucine from 3-methyl-2-oxobutanoate.UniRule annotationSAAS annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. 2-isopropylmalate synthase (leuA), 2-isopropylmalate synthase (leuA)
  2. 3-isopropylmalate dehydratase large subunit (leuC), 3-isopropylmalate dehydratase small subunit (leuD), 3-isopropylmalate dehydratase small subunit (leuD), 3-isopropylmalate dehydratase large subunit (leuC)
  3. 3-isopropylmalate dehydrogenase (leuB)
  4. Branched-chain-amino-acid aminotransferase (Psefu_1539)
This subpathway is part of the pathway L-leucine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-leucine from 3-methyl-2-oxobutanoate, the pathway L-leucine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesis, Leucine biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciPFUL743720:GHQV-3129-MONOMER.
UniPathwayiUPA00048; UER00071.

Names & Taxonomyi

Protein namesi
Recommended name:
3-isopropylmalate dehydratase small subunitUniRule annotation (EC:4.2.1.33UniRule annotation)
Alternative name(s):
Alpha-IPM isomeraseUniRule annotation
Isopropylmalate isomeraseUniRule annotation
Gene namesi
Name:leuDUniRule annotation
Ordered Locus Names:Psefu_3074Imported
OrganismiPseudomonas fulva (strain 12-X)Imported
Taxonomic identifieri743720 [NCBI]
Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas ›
Proteomesi
  • UP000000686 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Subunit structurei

Heterodimer of LeuC and LeuD.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi743720.Psefu_3074.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 132132Aconitase_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the LeuD family. LeuD type 1 subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105MQS. Bacteria.
COG0066. LUCA.
KOiK01704.
OMAiAFTTHTG.
OrthoDBiPOG091H02FJ.

Family and domain databases

Gene3Di3.20.19.10. 1 hit.
HAMAPiMF_01031. LeuD_type1. 1 hit.
InterProiIPR004431. 3-IsopropMal_deHydase_ssu.
IPR015937. Acoase/IPM_deHydtase.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
[Graphical view]
PANTHERiPTHR11670. PTHR11670. 1 hit.
PfamiPF00694. Aconitase_C. 1 hit.
[Graphical view]
SUPFAMiSSF52016. SSF52016. 1 hit.
TIGRFAMsiTIGR00171. leuD. 1 hit.

Sequencei

Sequence statusi: Complete.

F6A8G7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAFTQHTGL VCPLDRANVD TDQIIPKQFL KSIKRTGFGP NLFDEWRYLD 
        60         70         80         90        100
VGQPNQDNSK RPINKDFVLN FPRYQGASVL LARENFGCGS SREHAPWALD 
       110        120        130        140        150
EYGFRTVIAP SFADIFFNNS FKNGLLPIIL KAEEVDALFE QAEASEGYQL 
       160        170        180        190        200
TVDLEAQTVT RPDGVQYSFE VDAFRKHCLL NGLDDIGLTL QDAEAIRAFE 
       210 
VGYQQRQPWL FGAVK
Length:215
Mass (Da):24,328
Last modified:July 27, 2011 - v1
Checksum:i2B521DDBC18A2E28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002727 Genomic DNA. Translation: AEF23038.1.
RefSeqiWP_013792165.1. NC_015556.1.

Genome annotation databases

EnsemblBacteriaiAEF23038; AEF23038; Psefu_3074.
KEGGipfv:Psefu_3074.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002727 Genomic DNA. Translation: AEF23038.1.
RefSeqiWP_013792165.1. NC_015556.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi743720.Psefu_3074.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEF23038; AEF23038; Psefu_3074.
KEGGipfv:Psefu_3074.

Phylogenomic databases

eggNOGiENOG4105MQS. Bacteria.
COG0066. LUCA.
KOiK01704.
OMAiAFTTHTG.
OrthoDBiPOG091H02FJ.

Enzyme and pathway databases

UniPathwayiUPA00048; UER00071.
BioCyciPFUL743720:GHQV-3129-MONOMER.

Family and domain databases

Gene3Di3.20.19.10. 1 hit.
HAMAPiMF_01031. LeuD_type1. 1 hit.
InterProiIPR004431. 3-IsopropMal_deHydase_ssu.
IPR015937. Acoase/IPM_deHydtase.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
[Graphical view]
PANTHERiPTHR11670. PTHR11670. 1 hit.
PfamiPF00694. Aconitase_C. 1 hit.
[Graphical view]
SUPFAMiSSF52016. SSF52016. 1 hit.
TIGRFAMsiTIGR00171. leuD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiF6A8G7_PSEF1
AccessioniPrimary (citable) accession number: F6A8G7
Entry historyi
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.