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Protein

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase

Gene

gpmA

Organism
Gardnerella vaginalis (strain HMP9231)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotation

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei10 – 101Tele-phosphohistidine intermediateUniRule annotation
Binding sitei16 – 1612-phospho-D-glycerateUniRule annotation
Binding sitei61 – 6112-phospho-D-glycerateUniRule annotation
Binding sitei99 – 9912-phospho-D-glycerateUniRule annotation
Active sitei180 – 1801UniRule annotation
Binding sitei182 – 18212-phospho-D-glycerateUniRule annotation

GO - Molecular functioni

  1. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciGVAG1009464:GLDL-1008-MONOMER.
UniPathwayiUPA00109; UER00186.

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-dependent phosphoglycerate mutaseUniRule annotation (EC:5.4.2.11UniRule annotation)
Short name:
BPG-dependent PGAMUniRule annotation
Short name:
PGAMUniRule annotation
Short name:
PhosphoglyceromutaseUniRule annotation
Short name:
dPGMUniRule annotation
Gene namesi
Name:gpmAUniRule annotation
Ordered Locus Names:HMPREF9231_1017Imported
OrganismiGardnerella vaginalis (strain HMP9231)Imported
Taxonomic identifieri1009464 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeGardnerella
ProteomesiUP000009050 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliF6A3C0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni22 – 2322-phospho-D-glycerate bindingUniRule annotation
Regioni88 – 9142-phospho-D-glycerate bindingUniRule annotation
Regioni115 – 11622-phospho-D-glycerate bindingUniRule annotation

Sequence similaritiesi

Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.UniRule annotation

Phylogenomic databases

KOiK01834.
OrthoDBiEOG6C8N1H.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
HAMAPiMF_01039. PGAM_GpmA.
InterProiIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR001345. PG/BPGM_mutase_AS.
IPR005952. Phosphogly_mut1.
[Graphical view]
PANTHERiPTHR11931. PTHR11931. 1 hit.
PfamiPF00300. His_Phos_1. 1 hit.
[Graphical view]
SMARTiSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
TIGRFAMsiTIGR01258. pgm_1. 1 hit.
PROSITEiPS00175. PG_MUTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F6A3C0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTYKLVLLRH GQSAWNKTNQ FTGWVDVPLT EQGVEEAKHG GELLKEKNVL
60 70 80 90 100
PDIVFTSLLR RAINTANYAL DAADRLWIPV RRSWRLNERH YGALQGKNKS
110 120 130 140 150
EIRQEYGDEK FMIWRRSYAT PPPEIDPNDE YSQTNDPRYA GDPVPETEAL
160 170 180 190 200
ANVVTRVTPY WESDIIPELK SGKTVMIAAH GNSLRAIVKM LDNLSEEEIS
210 220 230 240
KVNIPTAIPL LYELDENFKP IKPRGEYLDP EAAAAGAAAV AAQGQK
Length:246
Mass (Da):27,713
Last modified:July 27, 2011 - v1
Checksum:iEA0BB88C4943DED9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002725 Genomic DNA. Translation: AEF30862.1.
RefSeqiYP_005838339.1. NC_017456.1.

Genome annotation databases

EnsemblBacteriaiAEF30862; AEF30862; HMPREF9231_1017.
KEGGigvh:HMPREF9231_1017.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002725 Genomic DNA. Translation: AEF30862.1.
RefSeqiYP_005838339.1. NC_017456.1.

3D structure databases

ProteinModelPortaliF6A3C0.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEF30862; AEF30862; HMPREF9231_1017.
KEGGigvh:HMPREF9231_1017.

Phylogenomic databases

KOiK01834.
OrthoDBiEOG6C8N1H.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00186.
BioCyciGVAG1009464:GLDL-1008-MONOMER.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
HAMAPiMF_01039. PGAM_GpmA.
InterProiIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR001345. PG/BPGM_mutase_AS.
IPR005952. Phosphogly_mut1.
[Graphical view]
PANTHERiPTHR11931. PTHR11931. 1 hit.
PfamiPF00300. His_Phos_1. 1 hit.
[Graphical view]
SMARTiSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
TIGRFAMsiTIGR01258. pgm_1. 1 hit.
PROSITEiPS00175. PG_MUTASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of Gardnerella vaginalis HMP9231."
    Durkin A.S., Kim M.K., Hostetler J., Torralba M., Gillis M., Methe B., Sutton G., Nelson K.E.
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HMP9231Imported.

Entry informationi

Entry nameiF6A3C0_GARVH
AccessioniPrimary (citable) accession number: F6A3C0
Entry historyi
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: April 29, 2015
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.