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F5ZUD5 (F5ZUD5_SALTU) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 14. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GMP reductase RuleBase RU003929 HAMAP-Rule MF_00596
EC=1.7.1.7 RuleBase RU003929 HAMAP-Rule MF_00596
Alternative name(s):
Guanosine 5'-monophosphate oxidoreductase HAMAP-Rule MF_00596
Gene names
Name:guaC HAMAP-Rule MF_00596 EMBL AEF06077.1
Ordered Locus Names:STMUK_0143 EMBL AEF06077.1
OrganismSalmonella typhimurium (strain ATCC 68169 / UK-1) [Complete proteome] [HAMAP]
Taxonomic identifier990282 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella ›

Protein attributes

Sequence length347 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides By similarity. RuleBase RU003929 HAMAP-Rule MF_00596

Catalytic activity

Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH. RuleBase RU003929 HAMAP-Rule MF_00596 SAAS SAAS001093

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00596

Sequence similarities

Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily. HAMAP-Rule MF_00596

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding108 – 13124NADP By similarity HAMAP-Rule MF_00596
Nucleotide binding216 – 23924NADP; ribose moiety By similarity HAMAP-Rule MF_00596

Sites

Active site1861Thioimidate intermediate By similarity HAMAP-Rule MF_00596
Metal binding1811Potassium; via carbonyl oxygen By similarity HAMAP-Rule MF_00596
Metal binding1831Potassium; via carbonyl oxygen By similarity HAMAP-Rule MF_00596

Sequences

Sequence LengthMass (Da)Tools
F5ZUD5 [UniParc].

Last modified July 27, 2011. Version 1.
Checksum: 71223D342F001B45

FASTA34737,139
        10         20         30         40         50         60 
MRIEEDLKLG FKDVLIRPKR STLKSRSDVE LERQFTFKHS GQTWSGVPII AANMDTVGTF 

        70         80         90        100        110        120 
EMAQALAGFD ILTAVHKHYT VEEWAAFINT ASADVLKHVM VSTGTSDADF EKTVQILALN 

       130        140        150        160        170        180 
PALNFVCIDV ANGYSEHFVQ FVAKAREAWP TKTICAGNVV TGEMCEELIL SGADIVKVGI 

       190        200        210        220        230        240 
GPGSVCTTRV KTGVGYPQLS AVIECADAAH GLGGMIVSDG GCTMPGDVAK AFGGGADFVM 

       250        260        270        280        290        300 
LGGMLAGHEE SGGSVVEENG EKFMLFYGMS SESAMNRHVG GVAKYRAAEG KTVKLPLRGP 

       310        320        330        340 
VGNTARDILG GLRSACTYVG ASRLKELTKR TTFIRVQEQE NRIFNSL

« Hide

References

[1]"Complete genome sequence of the universal killer Salmonella enterica serovar typhimurium UK-1 (ATCC 68169)."
Luo Y., Kong Q., Yang J., Golden G., Wanda S.Y., Jensen R.V., Ernst P.B., Curtiss R. III.
J. Bacteriol. 193:4035-4036(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 68169 / UK-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002614 Genomic DNA. Translation: AEF06077.1.
RefSeqYP_005250711.1. NC_016863.1.

3D structure databases

ProteinModelPortalF5ZUD5.
SMRF5ZUD5. Positions 3-338.
ModBaseSearch...

Proteomic databases

PRIDEF5ZUD5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEF06077; AEF06077; STMUK_0143.
GeneID11834281.
KEGGsej:STMUK_0143.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK00364.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_00596. GMP_reduct_type1.
InterProIPR013785. Aldolase_TIM.
IPR005993. GMP_reduct1.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
PfamPF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFPIRSF000235. GMP_reductase. 1 hit.
TIGRFAMsTIGR01305. GMP_reduct_1. 1 hit.
PROSITEPS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF5ZUD5_SALTU
AccessionPrimary (citable) accession number: F5ZUD5
Entry history
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: April 3, 2013
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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