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F5ZPA2

- F5ZPA2_SALTU

UniProt

F5ZPA2 - F5ZPA2_SALTU

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Protein

Isocitrate dehydrogenase [NADP]

Gene

icdA

Organism
Salmonella typhimurium (strain ATCC 68169 / UK-1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciSENT990282:GHYP-1206-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdAImported
Ordered Locus Names:STMUK_1206Imported
OrganismiSalmonella typhimurium (strain ATCC 68169 / UK-1)Imported
Taxonomic identifieri990282 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000008278: Chromosome

PTM / Processingi

Proteomic databases

PRIDEiF5ZPA2.

Structurei

3D structure databases

ProteinModelPortaliF5ZPA2.
SMRiF5ZPA2. Positions 1-416.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F5ZPA2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MESKVVVPVE GKKITLQNGK LNVPENPIIP FIEGDGIGVD VTPAMLKVVD
60 70 80 90 100
AAVEKAYKGE RKISWMEIYT GEKSTQVYGQ DVWLPAETLD LIRDYRVAIK
110 120 130 140 150
GPLTTPVGGG IRSLNVALRQ ELDLYVCLRP VRYYQGTPSP VKHPELTDMV
160 170 180 190 200
IFRENSEDIY AGIEWKADSA DAEKVIKFLR EEMGVKKIRF PEHCGIGIKP
210 220 230 240 250
CSEEGTKRLV RAAIEYAITN DRDSVTLVHK GNIMKFTEGA FKDWGYQLAR
260 270 280 290 300
DEFGGELIDG GPWLKIKNPN TGKEIVVKDV IADAFLQQIL LRPAEYDVIA
310 320 330 340 350
CMNLNGDYIS DALAAQVGGI GIAPGANIGD ECALFEATHG TAPKYAGQDK
360 370 380 390 400
VNPGSIILSA EMMLRHMQWF EAADLIVKGM EGAIAAKTVT YDFERLMEGA
410
KLLKCSEFGD AIIANM
Length:416
Mass (Da):45,788
Last modified:July 27, 2011 - v1
Checksum:i8AF207D3D3289F0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002614 Genomic DNA. Translation: AEF07112.1.
RefSeqiYP_005251746.1. NC_016863.1.

Genome annotation databases

EnsemblBacteriaiAEF07112; AEF07112; STMUK_1206.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002614 Genomic DNA. Translation: AEF07112.1 .
RefSeqi YP_005251746.1. NC_016863.1.

3D structure databases

ProteinModelPortali F5ZPA2.
SMRi F5ZPA2. Positions 1-416.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi F5ZPA2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEF07112 ; AEF07112 ; STMUK_1206 .

Enzyme and pathway databases

BioCyci SENT990282:GHYP-1206-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the universal killer Salmonella enterica serovar typhimurium UK-1 (ATCC 68169)."
    Luo Y., Kong Q., Yang J., Golden G., Wanda S.Y., Jensen R.V., Ernst P.B., Curtiss R. III.
    J. Bacteriol. 193:4035-4036(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 68169 / UK-1Imported.

Entry informationi

Entry nameiF5ZPA2_SALTU
AccessioniPrimary (citable) accession number: F5ZPA2
Entry historyi
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3