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F5ZPA2

- F5ZPA2_SALTU

UniProt

F5ZPA2 - F5ZPA2_SALTU

Protein

Isocitrate dehydrogenase [NADP]

Gene

icdA

Organism
Salmonella typhimurium (strain ATCC 68169 / UK-1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 24 (01 Oct 2014)
      Sequence version 1 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciSENT990282:GHYP-1206-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Name:icdAImported
    Ordered Locus Names:STMUK_1206Imported
    OrganismiSalmonella typhimurium (strain ATCC 68169 / UK-1)Imported
    Taxonomic identifieri990282 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000008278: Chromosome

    PTM / Processingi

    Proteomic databases

    PRIDEiF5ZPA2.

    Structurei

    3D structure databases

    ProteinModelPortaliF5ZPA2.
    SMRiF5ZPA2. Positions 1-416.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F5ZPA2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESKVVVPVE GKKITLQNGK LNVPENPIIP FIEGDGIGVD VTPAMLKVVD    50
    AAVEKAYKGE RKISWMEIYT GEKSTQVYGQ DVWLPAETLD LIRDYRVAIK 100
    GPLTTPVGGG IRSLNVALRQ ELDLYVCLRP VRYYQGTPSP VKHPELTDMV 150
    IFRENSEDIY AGIEWKADSA DAEKVIKFLR EEMGVKKIRF PEHCGIGIKP 200
    CSEEGTKRLV RAAIEYAITN DRDSVTLVHK GNIMKFTEGA FKDWGYQLAR 250
    DEFGGELIDG GPWLKIKNPN TGKEIVVKDV IADAFLQQIL LRPAEYDVIA 300
    CMNLNGDYIS DALAAQVGGI GIAPGANIGD ECALFEATHG TAPKYAGQDK 350
    VNPGSIILSA EMMLRHMQWF EAADLIVKGM EGAIAAKTVT YDFERLMEGA 400
    KLLKCSEFGD AIIANM 416
    Length:416
    Mass (Da):45,788
    Last modified:July 27, 2011 - v1
    Checksum:i8AF207D3D3289F0B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002614 Genomic DNA. Translation: AEF07112.1.
    RefSeqiYP_005251746.1. NC_016863.1.

    Genome annotation databases

    EnsemblBacteriaiAEF07112; AEF07112; STMUK_1206.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002614 Genomic DNA. Translation: AEF07112.1 .
    RefSeqi YP_005251746.1. NC_016863.1.

    3D structure databases

    ProteinModelPortali F5ZPA2.
    SMRi F5ZPA2. Positions 1-416.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi F5ZPA2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEF07112 ; AEF07112 ; STMUK_1206 .

    Enzyme and pathway databases

    BioCyci SENT990282:GHYP-1206-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the universal killer Salmonella enterica serovar typhimurium UK-1 (ATCC 68169)."
      Luo Y., Kong Q., Yang J., Golden G., Wanda S.Y., Jensen R.V., Ernst P.B., Curtiss R. III.
      J. Bacteriol. 193:4035-4036(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 68169 / UK-1Imported.

    Entry informationi

    Entry nameiF5ZPA2_SALTU
    AccessioniPrimary (citable) accession number: F5ZPA2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 27, 2011
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 24 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3