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F5YN18 (F5YN18_TREPZ) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:TREPR_0367 EMBL AEF83734.1
OrganismTreponema primitia (strain ATCC BAA-887 / DSM 12427 / ZAS-2) [Complete proteome] [HAMAP] EMBL AEF83734.1
Taxonomic identifier545694 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema

Protein attributes

Sequence length392 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain146 – 359214ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding179 – 23456ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding3161Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3301Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3301Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3321Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
F5YN18 [UniParc].

Last modified July 27, 2011. Version 1.
Checksum: A01C96B93E8F721C

FASTA39243,434
        10         20         30         40         50         60 
MRIRVGVLFG GKSVEHEVSV ISGIQAINAF DQEKYEIIPI YMTREGELYT GDVADKIEEY 

        70         80         90        100        110        120 
RDIPALLKKL QRVTLINEAG KYLLIKYPVK AWGKQSCGEV DLIFPIVHGT NVEDGALQGY 

       130        140        150        160        170        180 
LKTLSIPFAG CDVCASAVGM DKYVQKAVLK YNNIPVLDGV RVLSSAYYKD TEKLLNEIEQ 

       190        200        210        220        230        240 
FAPYPIIVKP SNLGSSIGIK KAFNREELTD AFEYTFQYAH TALVEHALTN FREINCAVLG 

       250        260        270        280        290        300 
DQDSAIASEC EEPINTDAIL SYKDKYVSGD KTGSKGMSSA KRILPADLSP ELREEIRSLA 

       310        320        330        340        350        360 
LKTFQALGCN GVSRIDLFVD KDTNTVLVNE INTIPGSLSF YLWEPVGVPY KELLDRLVSL 

       370        380        390 
TLKREREESS LSFSIETNIL VNFAGGAKGG KR 

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References

[1]"Complete sequence of Treponema primitia strain ZAS-2."
Tetu S.G., Matson E., Ren Q., Seshadri R., Elbourne L., Hassan K.A., Durkin A., Radune D., Mohamoud Y., Shay R., Jin S., Zhang X., Lucey K., Ballor N.R., Ottesen E., Rosenthal R., Allen A., Leadbetter J.R., Paulsen I.T.
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-887 / DSM 12427 / ZAS-2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001843 Genomic DNA. Translation: AEF83734.1.
RefSeqYP_004532518.1. NC_015578.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEF83734; AEF83734; TREPR_0367.
GeneID10681338.
KEGGtpi:TREPR_0367.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.

Enzyme and pathway databases

BioCycTPRI545694:GH5L-3600-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF5YN18_TREPZ
AccessionPrimary (citable) accession number: F5YN18
Entry history
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: February 19, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)