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F5YN18

- F5YN18_TREPZ

UniProt

F5YN18 - F5YN18_TREPZ

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Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Treponema primitia (strain ATCC BAA-887 / DSM 12427 / ZAS-2)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotationSAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotation

Cofactori

Note: Binds 2 magnesium or manganese ions per subunit.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi316 – 3161Magnesium or manganese 1UniRule annotation
Metal bindingi330 – 3301Magnesium or manganese 1UniRule annotation
Metal bindingi330 – 3301Magnesium or manganese 2UniRule annotation
Metal bindingi332 – 3321Magnesium or manganese 2UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi179 – 23456ATPUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  3. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationSAAS annotation

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciTPRI545694:GH5L-3600-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlUniRule annotation
Ordered Locus Names:TREPR_0367Imported
OrganismiTreponema primitia (strain ATCC BAA-887 / DSM 12427 / ZAS-2)Imported
Taxonomic identifieri545694 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
ProteomesiUP000009223: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini146 – 359214ATP-graspUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotation
Contains 1 ATP-grasp domain.UniRule annotation
Contains ATP-grasp domain.SAAS annotation

Phylogenomic databases

KOiK01921.
OMAiIECGVLG.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F5YN18-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRIRVGVLFG GKSVEHEVSV ISGIQAINAF DQEKYEIIPI YMTREGELYT
60 70 80 90 100
GDVADKIEEY RDIPALLKKL QRVTLINEAG KYLLIKYPVK AWGKQSCGEV
110 120 130 140 150
DLIFPIVHGT NVEDGALQGY LKTLSIPFAG CDVCASAVGM DKYVQKAVLK
160 170 180 190 200
YNNIPVLDGV RVLSSAYYKD TEKLLNEIEQ FAPYPIIVKP SNLGSSIGIK
210 220 230 240 250
KAFNREELTD AFEYTFQYAH TALVEHALTN FREINCAVLG DQDSAIASEC
260 270 280 290 300
EEPINTDAIL SYKDKYVSGD KTGSKGMSSA KRILPADLSP ELREEIRSLA
310 320 330 340 350
LKTFQALGCN GVSRIDLFVD KDTNTVLVNE INTIPGSLSF YLWEPVGVPY
360 370 380 390
KELLDRLVSL TLKREREESS LSFSIETNIL VNFAGGAKGG KR
Length:392
Mass (Da):43,434
Last modified:July 27, 2011 - v1
Checksum:iA01C96B93E8F721C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001843 Genomic DNA. Translation: AEF83734.1.
RefSeqiYP_004532518.1. NC_015578.1.

Genome annotation databases

EnsemblBacteriaiAEF83734; AEF83734; TREPR_0367.
GeneIDi10681338.
KEGGitpi:TREPR_0367.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001843 Genomic DNA. Translation: AEF83734.1 .
RefSeqi YP_004532518.1. NC_015578.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEF83734 ; AEF83734 ; TREPR_0367 .
GeneIDi 10681338.
KEGGi tpi:TREPR_0367.

Phylogenomic databases

KOi K01921.
OMAi IECGVLG.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci TPRI545694:GH5L-3600-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPi MF_00047. Dala_Dala_lig.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
PANTHERi PTHR23132. PTHR23132. 1 hit.
Pfami PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Treponema primitia strain ZAS-2."
    Tetu S.G., Matson E., Ren Q., Seshadri R., Elbourne L., Hassan K.A., Durkin A., Radune D., Mohamoud Y., Shay R., Jin S., Zhang X., Lucey K., Ballor N.R., Ottesen E., Rosenthal R., Allen A., Leadbetter J.R., Paulsen I.T.
    Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-887 / DSM 12427 / ZAS-2Imported.

Entry informationi

Entry nameiF5YN18_TREPZ
AccessioniPrimary (citable) accession number: F5YN18
Entry historyi
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3