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F5YN18

- F5YN18_TREPZ

UniProt

F5YN18 - F5YN18_TREPZ

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Protein

D-alanine--D-alanine ligase

Gene
ddl, TREPR_0367
Organism
Treponema primitia (strain ATCC BAA-887 / DSM 12427 / ZAS-2)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cell wall formation By similarity.UniRule annotationSAAS annotations

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotations

Cofactori

Binds 2 magnesium or manganese ions per subunit By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi316 – 3161Magnesium or manganese 1 By similarityUniRule annotation
Metal bindingi330 – 3301Magnesium or manganese 1 By similarityUniRule annotation
Metal bindingi330 – 3301Magnesium or manganese 2 By similarityUniRule annotation
Metal bindingi332 – 3321Magnesium or manganese 2 By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi179 – 23456ATP By similarityUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  2. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotations, Peptidoglycan synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, MagnesiumUniRule annotationSAAS annotations, ManganeseUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciTPRI545694:GH5L-3600-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene namesi
Name:ddlUniRule annotation
Ordered Locus Names:TREPR_0367Imported
OrganismiTreponema primitia (strain ATCC BAA-887 / DSM 12427 / ZAS-2)Imported
Taxonomic identifieri545694 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
ProteomesiUP000009223: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini146 – 359214ATP-grasp By similarityUniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ATP-grasp domain.UniRule annotation
Contains ATP-grasp domain.SAAS annotations

Phylogenomic databases

KOiK01921.
OMAiIECGVLG.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F5YN18-1 [UniParc]FASTAAdd to Basket

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MRIRVGVLFG GKSVEHEVSV ISGIQAINAF DQEKYEIIPI YMTREGELYT    50
GDVADKIEEY RDIPALLKKL QRVTLINEAG KYLLIKYPVK AWGKQSCGEV 100
DLIFPIVHGT NVEDGALQGY LKTLSIPFAG CDVCASAVGM DKYVQKAVLK 150
YNNIPVLDGV RVLSSAYYKD TEKLLNEIEQ FAPYPIIVKP SNLGSSIGIK 200
KAFNREELTD AFEYTFQYAH TALVEHALTN FREINCAVLG DQDSAIASEC 250
EEPINTDAIL SYKDKYVSGD KTGSKGMSSA KRILPADLSP ELREEIRSLA 300
LKTFQALGCN GVSRIDLFVD KDTNTVLVNE INTIPGSLSF YLWEPVGVPY 350
KELLDRLVSL TLKREREESS LSFSIETNIL VNFAGGAKGG KR 392
Length:392
Mass (Da):43,434
Last modified:July 27, 2011 - v1
Checksum:iA01C96B93E8F721C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001843 Genomic DNA. Translation: AEF83734.1.
RefSeqiYP_004532518.1. NC_015578.1.

Genome annotation databases

EnsemblBacteriaiAEF83734; AEF83734; TREPR_0367.
GeneIDi10681338.
KEGGitpi:TREPR_0367.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001843 Genomic DNA. Translation: AEF83734.1 .
RefSeqi YP_004532518.1. NC_015578.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEF83734 ; AEF83734 ; TREPR_0367 .
GeneIDi 10681338.
KEGGi tpi:TREPR_0367.

Phylogenomic databases

KOi K01921.
OMAi IECGVLG.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci TPRI545694:GH5L-3600-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPi MF_00047. Dala_Dala_lig.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
PANTHERi PTHR23132. PTHR23132. 1 hit.
Pfami PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Treponema primitia strain ZAS-2."
    Tetu S.G., Matson E., Ren Q., Seshadri R., Elbourne L., Hassan K.A., Durkin A., Radune D., Mohamoud Y., Shay R., Jin S., Zhang X., Lucey K., Ballor N.R., Ottesen E., Rosenthal R., Allen A., Leadbetter J.R., Paulsen I.T.
    Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-887 / DSM 12427 / ZAS-2.

Entry informationi

Entry nameiF5YN18_TREPZ
AccessioniPrimary (citable) accession number: F5YN18
Entry historyi
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: June 11, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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