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F5YN18

- F5YN18_TREPZ

UniProt

F5YN18 - F5YN18_TREPZ

Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Treponema primitia (strain ATCC BAA-887 / DSM 12427 / ZAS-2)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 20 (01 Oct 2014)
      Sequence version 1 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Cell wall formation.UniRule annotationSAAS annotation

    Catalytic activityi

    ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi316 – 3161Magnesium or manganese 1UniRule annotation
    Metal bindingi330 – 3301Magnesium or manganese 1UniRule annotation
    Metal bindingi330 – 3301Magnesium or manganese 2UniRule annotation
    Metal bindingi332 – 3321Magnesium or manganese 2UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi179 – 23456ATPUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. D-alanine-D-alanine ligase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP
    4. manganese ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
    2. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    LigaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTPRI545694:GH5L-3600-MONOMER.
    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
    Alternative name(s):
    D-Ala-D-Ala ligaseUniRule annotation
    D-alanylalanine synthetaseUniRule annotation
    Gene namesi
    Name:ddlUniRule annotation
    Ordered Locus Names:TREPR_0367Imported
    OrganismiTreponema primitia (strain ATCC BAA-887 / DSM 12427 / ZAS-2)Imported
    Taxonomic identifieri545694 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
    ProteomesiUP000009223: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini146 – 359214ATP-graspUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the D-alanine--D-alanine ligase family.UniRule annotation
    Contains 1 ATP-grasp domain.UniRule annotation
    Contains ATP-grasp domain.SAAS annotation

    Phylogenomic databases

    KOiK01921.
    OMAiIECGVLG.

    Family and domain databases

    Gene3Di3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    HAMAPiMF_00047. Dala_Dala_lig.
    InterProiIPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR000291. D-Ala_lig_Van_CS.
    IPR005905. D_ala_D_ala.
    IPR011095. Dala_Dala_lig_C.
    IPR011127. Dala_Dala_lig_N.
    IPR016185. PreATP-grasp_dom.
    [Graphical view]
    PANTHERiPTHR23132. PTHR23132. 1 hit.
    PfamiPF07478. Dala_Dala_lig_C. 1 hit.
    PF01820. Dala_Dala_lig_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF52440. SSF52440. 1 hit.
    TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
    PROSITEiPS50975. ATP_GRASP. 1 hit.
    PS00844. DALA_DALA_LIGASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F5YN18-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRIRVGVLFG GKSVEHEVSV ISGIQAINAF DQEKYEIIPI YMTREGELYT    50
    GDVADKIEEY RDIPALLKKL QRVTLINEAG KYLLIKYPVK AWGKQSCGEV 100
    DLIFPIVHGT NVEDGALQGY LKTLSIPFAG CDVCASAVGM DKYVQKAVLK 150
    YNNIPVLDGV RVLSSAYYKD TEKLLNEIEQ FAPYPIIVKP SNLGSSIGIK 200
    KAFNREELTD AFEYTFQYAH TALVEHALTN FREINCAVLG DQDSAIASEC 250
    EEPINTDAIL SYKDKYVSGD KTGSKGMSSA KRILPADLSP ELREEIRSLA 300
    LKTFQALGCN GVSRIDLFVD KDTNTVLVNE INTIPGSLSF YLWEPVGVPY 350
    KELLDRLVSL TLKREREESS LSFSIETNIL VNFAGGAKGG KR 392
    Length:392
    Mass (Da):43,434
    Last modified:July 27, 2011 - v1
    Checksum:iA01C96B93E8F721C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001843 Genomic DNA. Translation: AEF83734.1.
    RefSeqiYP_004532518.1. NC_015578.1.

    Genome annotation databases

    EnsemblBacteriaiAEF83734; AEF83734; TREPR_0367.
    GeneIDi10681338.
    KEGGitpi:TREPR_0367.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001843 Genomic DNA. Translation: AEF83734.1 .
    RefSeqi YP_004532518.1. NC_015578.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEF83734 ; AEF83734 ; TREPR_0367 .
    GeneIDi 10681338.
    KEGGi tpi:TREPR_0367.

    Phylogenomic databases

    KOi K01921.
    OMAi IECGVLG.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .
    BioCyci TPRI545694:GH5L-3600-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    HAMAPi MF_00047. Dala_Dala_lig.
    InterProi IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR000291. D-Ala_lig_Van_CS.
    IPR005905. D_ala_D_ala.
    IPR011095. Dala_Dala_lig_C.
    IPR011127. Dala_Dala_lig_N.
    IPR016185. PreATP-grasp_dom.
    [Graphical view ]
    PANTHERi PTHR23132. PTHR23132. 1 hit.
    Pfami PF07478. Dala_Dala_lig_C. 1 hit.
    PF01820. Dala_Dala_lig_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52440. SSF52440. 1 hit.
    TIGRFAMsi TIGR01205. D_ala_D_alaTIGR. 1 hit.
    PROSITEi PS50975. ATP_GRASP. 1 hit.
    PS00844. DALA_DALA_LIGASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Treponema primitia strain ZAS-2."
      Tetu S.G., Matson E., Ren Q., Seshadri R., Elbourne L., Hassan K.A., Durkin A., Radune D., Mohamoud Y., Shay R., Jin S., Zhang X., Lucey K., Ballor N.R., Ottesen E., Rosenthal R., Allen A., Leadbetter J.R., Paulsen I.T.
      Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-887 / DSM 12427 / ZAS-2Imported.

    Entry informationi

    Entry nameiF5YN18_TREPZ
    AccessioniPrimary (citable) accession number: F5YN18
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 27, 2011
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3