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Protein

Lysine--tRNA ligase

Gene

lysS

Organism
Treponema azotonutricium (strain ATCC BAA-888 / DSM 13862 / ZAS-9)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotation, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciTAZO545695:G1GXX-485-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine--tRNA ligaseUniRule annotation (EC:6.1.1.6UniRule annotation)
Alternative name(s):
Lysyl-tRNA synthetaseUniRule annotation
Short name:
LysRSUniRule annotation
Gene namesi
Name:lysSUniRule annotationImported
Ordered Locus Names:TREAZ_1825Imported
OrganismiTreponema azotonutricium (strain ATCC BAA-888 / DSM 13862 / ZAS-9)Imported
Taxonomic identifieri545695 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
Proteomesi
  • UP000009222 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi545695.TREAZ_1825

Structurei

3D structure databases

ProteinModelPortaliF5YBY1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili154 – 174Sequence analysisAdd BLAST21

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 50"HIGH" regionUniRule annotation9
Motifi294 – 298"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG4105DK7 Bacteria
COG1384 LUCA
KOiK04566
OMAiDWPMRWA
OrthoDBiPOG091H0CBT

Family and domain databases

Gene3Di1.10.10.350, 1 hit
2.30.30.300, 1 hit
3.40.50.620, 2 hits
HAMAPiMF_00177 Lys_tRNA_synth_class1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR002904 Lys-tRNA-ligase
IPR023386 Lys-tRNA-ligase_insertion_sf
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR37940 PTHR37940, 1 hit
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00467 lysS_arch, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

F5YBY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKKNEASGA QASAHWADET AAKILREKGD KELYTCASGI TPSGTVHIGN
60 70 80 90 100
FREIISTDLV VRALRDKGKK VRFIYSWDDY DVFRKVPKNM PQQEALNGHL
110 120 130 140 150
RFPITMVPDP WGRDSSYARH HEVDIETVLP KVGVHPEFLY QAENYRSSKY
160 170 180 190 200
AEGIRKALEH REALKNILDK FRDEEHKIQG EWWPVSAFCS ACNKDDTEID
210 220 230 240 250
SWDGEWGVTY HCNSCGHKET ADIRTAKGIK LFWRIDWPMR WEYEKVDFEP
260 270 280 290 300
AGKDHHSQGG SFDTAKHVCK DVYDWDAPVT FRYDFIGTKG LPGKMSSSSG
310 320 330 340 350
NVITIEDVLN VYTPEVARYL FAGTRPNTEF TISFDLDVIK IYEDYDKTER
360 370 380 390 400
IAFKAEPAKD EAVYQKERRI YELSQAAVTA EGKTKMPEIM PFQVPFRHLC
410 420 430 440 450
NLIQIADGDI DKAIASIANL KPEQIPALKA RAACAKYWID ECAPEEFRFK
460 470 480 490 500
LREPGETSDL ADNEKAAIKQ LRDEVISKID SFTDDKGCAE AIYKIAEAQG
510 520 530 540
MEGKALFRAA YQALIGKDQG PRLANFLRSI NKDRLLGILK AY
Length:542
Mass (Da):61,709
Last modified:July 27, 2011 - v1
Checksum:i34935944DCC4AD3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001841 Genomic DNA Translation: AEF80924.1
RefSeqiWP_015710207.1, NC_015577.1

Genome annotation databases

EnsemblBacteriaiAEF80924; AEF80924; TREAZ_1825
KEGGitaz:TREAZ_1825

Similar proteinsi

Entry informationi

Entry nameiF5YBY1_TREAZ
AccessioniPrimary (citable) accession number: F5YBY1
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health