ID   F5Y779_LEAAZ            Unreviewed;       450 AA.
AC   F5Y779;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   27-MAR-2024, entry version 50.
DE   SubName: Full=Hexokinase {ECO:0000313|EMBL:AEF80993.1};
GN   OrderedLocusNames=TREAZ_1115 {ECO:0000313|EMBL:AEF80993.1};
OS   Leadbettera azotonutricia (strain ATCC BAA-888 / DSM 13862 / ZAS-9)
OS   (Treponema azotonutricium).
OC   Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Breznakiellaceae;
OC   Leadbettera.
OX   NCBI_TaxID=545695 {ECO:0000313|EMBL:AEF80993.1, ECO:0000313|Proteomes:UP000009222};
RN   [1] {ECO:0000313|Proteomes:UP000009222}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-888 / DSM 13862 / ZAS-9
RC   {ECO:0000313|Proteomes:UP000009222};
RA   Tetu S.G., Matson E., Ren Q., Seshadri R., Elbourne L., Hassan K.A.,
RA   Durkin A., Radune D., Mohamoud Y., Shay R., Jin S., Zhang X., Lucey K.,
RA   Ballor N.R., Ottesen E., Rosenthal R., Allen A., Leadbetter J.R.,
RA   Paulsen I.T.;
RT   "Complete sequence of Treponema azotonutricium strain ZAS-9.";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AEF80993.1, ECO:0000313|Proteomes:UP000009222}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-888 / DSM 13862 / ZAS-9
RC   {ECO:0000313|Proteomes:UP000009222};
RX   PubMed=21326336; DOI=10.1038/ismej.2011.3;
RA   Rosenthal A.Z., Matson E.G., Eldar A., Leadbetter J.R.;
RT   "RNA-seq reveals cooperative metabolic interactions between two termite-gut
RT   spirochete species in co-culture.";
RL   ISME J. 5:1133-1142(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+);
CC         Xref=Rhea:RHEA:16125, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:37721, ChEBI:CHEBI:61527, ChEBI:CHEBI:456216; EC=2.7.1.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001397};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16126;
CC         Evidence={ECO:0000256|ARBA:ARBA00001397};
CC   -!- PATHWAY: Carbohydrate degradation. {ECO:0000256|ARBA:ARBA00004921}.
CC   -!- PATHWAY: Carbohydrate metabolism. {ECO:0000256|ARBA:ARBA00005007}.
CC   -!- SIMILARITY: Belongs to the hexokinase family.
CC       {ECO:0000256|ARBA:ARBA00009225}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP001841; AEF80993.1; -; Genomic_DNA.
DR   RefSeq; WP_015710875.1; NC_015577.1.
DR   AlphaFoldDB; F5Y779; -.
DR   STRING; 545695.TREAZ_1115; -.
DR   KEGG; taz:TREAZ_1115; -.
DR   eggNOG; COG5026; Bacteria.
DR   HOGENOM; CLU_014393_5_3_12; -.
DR   InParanoid; F5Y779; -.
DR   OrthoDB; 6383434at2; -.
DR   UniPathway; UPA00109; UER00180.
DR   Proteomes; UP000009222; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR   GO; GO:0004396; F:hexokinase activity; IEA:InterPro.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0001678; P:intracellular glucose homeostasis; IEA:InterPro.
DR   CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR   Gene3D; 3.30.420.40; -; 1.
DR   Gene3D; 3.40.367.20; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR001312; Hexokinase.
DR   InterPro; IPR022673; Hexokinase_C.
DR   InterPro; IPR022672; Hexokinase_N.
DR   PANTHER; PTHR19443; HEXOKINASE; 1.
DR   PANTHER; PTHR19443:SF16; HEXOKINASE TYPE 1-RELATED; 1.
DR   Pfam; PF00349; Hexokinase_1; 1.
DR   Pfam; PF03727; Hexokinase_2; 1.
DR   PRINTS; PR00475; HEXOKINASE.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR   PROSITE; PS51748; HEXOKINASE_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:AEF80993.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009222};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          28..200
FT                   /note="Hexokinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00349"
FT   DOMAIN          223..448
FT                   /note="Hexokinase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03727"
SQ   SEQUENCE   450 AA;  48276 MW;  FB803661A9AF351C CRC64;
     MGKFNPQALS EFARYYGFHY DIIDPVALAE DVRIDMERGL KGQPTSLPMI PAFISPVAKA
     ESGETVVALD AGGTNLRASL VRFDEYGKAQ PSATEKVPMP GTSGRVNAEA FFDQIASVAA
     PLIEKSPDPI KGIGFCFSYP MEITKDADGI LLAFSKEVDA PDVVGKAIGK GLKEALKRRK
     VKVPERVVLL NDTVATLLSG LADPSLSTRK GADLYGVPGG PVVGFILGTG FNTAYPESSI
     PKIKFESKTN PQIVVCESGT FASRYVGFLD KEYDSTTKNP GGYTLEKATA GAYLGPLTFH
     ILKRAVKDGL VKFAKSKEFL DWPALQTKDL NAFMHAPLAM EGPIGALFEK DEIDALRSFV
     YITSIITERA ALLSAGVVAG AVLKSSEGFD PFVPVRIAVE GTTYMIYKGM RTALEAWLHI
     MLTKGKPRSY VIGPVEQASL FGAAVAALTK
//