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Protein

Bifunctional protein PutA

Gene

putA

Organism
Ramlibacter tataouinensis (strain ATCC BAA-407 / DSM 14655 / LMG 21543 / TTB310)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Oxidizes proline to glutamate for use as a carbon and nitrogen source.UniRule annotation

Catalytic activityi

L-glutamate 5-semialdehyde + NAD+ + H2O = L-glutamate + NADH.UniRule annotation
L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: L-proline degradation into L-glutamate

This protein is involved in step 1 and 2 of the subpathway that synthesizes L-glutamate from L-proline.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Bifunctional protein PutA (putA)
  2. Bifunctional protein PutA (putA)
This subpathway is part of the pathway L-proline degradation into L-glutamate, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate from L-proline, the pathway L-proline degradation into L-glutamate and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei778UniRule annotation1
Active sitei812UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation, OxidoreductaseUniRule annotation, RepressorUniRule annotation
Biological processProline metabolismUniRule annotation, Transcription, Transcription regulationUniRule annotation
LigandFADUniRule annotation, Flavoprotein, NADUniRule annotation

Enzyme and pathway databases

BioCyciRTAT365046:G1GYB-457-MONOMER
UniPathwayiUPA00261; UER00373
UPA00261; UER00374

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein PutAUniRule annotation
Including the following 2 domains:
Proline dehydrogenaseUniRule annotation (EC:1.5.5.2UniRule annotation)
Alternative name(s):
Proline oxidaseUniRule annotation
Delta-1-pyrroline-5-carboxylate dehydrogenaseUniRule annotation (EC:1.2.1.88UniRule annotation)
Short name:
P5C dehydrogenaseUniRule annotation
Alternative name(s):
L-glutamate gamma-semialdehyde dehydrogenaseUniRule annotation
Gene namesi
Name:putAImported
Ordered Locus Names:Rta_04440Imported
OrganismiRamlibacter tataouinensis (strain ATCC BAA-407 / DSM 14655 / LMG 21543 / TTB310)Imported
Taxonomic identifieri365046 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeRamlibacter
Proteomesi
  • UP000008385 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi365046.Rta_04440

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 162Pro_dh-DNA_bdgInterPro annotationAdd BLAST106
Domaini182 – 490Pro_dhInterPro annotationAdd BLAST309
Domaini562 – 1000AldedhInterPro annotationAdd BLAST439

Sequence similaritiesi

In the C-terminal section; belongs to the aldehyde dehydrogenase family.UniRule annotation
In the N-terminal section; belongs to the proline dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C26 Bacteria
COG0506 LUCA
COG4230 LUCA
KOiK13821
OMAiVRIYAPV
OrthoDBiPOG091H043M

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 2 hits
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR025703 Bifunct_PutA
IPR005933 Delta1-pyrroline-5-COlate_DH-3
IPR029041 FAD-linked_oxidoreductase-like
IPR024089 PRODH_PutA_dom_I/II
IPR024082 PRODH_PutA_dom_II
IPR002872 Proline_DH_dom
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
PF01619 Pro_dh, 1 hit
PF14850 Pro_dh-DNA_bdg, 1 hit
PIRSFiPIRSF000197 Bifunct_PutA, 2 hits
SUPFAMiSSF51730 SSF51730, 1 hit
SSF53720 SSF53720, 1 hit
SSF81935 SSF81935, 1 hit
TIGRFAMsiTIGR01238 D1pyr5carbox3, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit

Sequencei

Sequence statusi: Complete.

F5Y611-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTPAADRLP SPYRPEAAVL ADRLRRLEGA LDWAAAAAAA APWVQAVRRH
60 70 80 90 100
PPPFWAMESL LKEYPISSAE GLALMRLAEA LLRVPDAETA VALTADQLGR
110 120 130 140 150
ADFSGAADGA LARLSNAAIA LSKKLLPEQA DAPDGGGLLA RLGARTVVAA
160 170 180 190 200
TLRAVQLLGR QFVLGQDIGA ALDEADAARR AQPALLFSYD MLGEGARTAH
210 220 230 240 250
DAERYLASYR AAIAAIAARG DAARAPAESD GISIKLSALH PRYEEAQRER
260 270 280 290 300
VLRELVPRVW QLCEQAARSN LNLTIDAEEV DRLELSLAVF EALAESVAQR
310 320 330 340 350
HPRWSGFGLA LQSYQTRALE LIEHVADLAR RLGLRFMCRL VKGAYWDAEI
360 370 380 390 400
KRAQELGLPH YPVFTHKQHT DVSYLACARA LLQAADAIYP QFATHNAGTI
410 420 430 440 450
AAIRQMAERE GAAFELQRLH GMGEGVYREI LSRYTPSGQA GLAPTQPPPS
460 470 480 490 500
GGGFEPRVRV YAPVGKHRDL LAYLVRRLLE NGANSSFVHQ LADESVGLDQ
510 520 530 540 550
LLASPLAQAR ASLARLAQQP ALPLPAGLYG PGRRNSAGLD LAVAAMRAPL
560 570 580 590 600
LAAHAQLRVP PVAQAQAGEA PAAVARAAAA FPAWDARPVA ERAQALRRAA
610 620 630 640 650
DAMEARMAPL CALLVAEGRK TWGDAVAEVR EAVDFLRYYA GEAERVMQPA
660 670 680 690 700
LLPGPTGERN ELRLAGRGPW VCISPWNFPL AIFTGQVAAA LAAGNTVLAK
710 720 730 740 750
PAEQTPAVAR EAVRLLHEAG VPPDALQLLH GPGETVGAAL VAAPGVAGVV
760 770 780 790 800
FTGSTQVARL IQRALAAKDG AIVPLIAETG GINAMLVDST ALPEQVADAV
810 820 830 840 850
VQSAFRSAGQ RCSALRLLCV HEGIADAVIE MVAGAARELT VGDPALLSTD
860 870 880 890 900
VGPVIDAQAF AGLQGELQRL RQTARAVLAP AEAPAAPPHC IAPQAFEVER
910 920 930 940 950
VTDVQREIFG PVLHIARWSG DPQAVVEQVN ALGYGLTLGI QTRIDSRAQA
960 970 980 990 1000
LAARARVGNV YVNRNMIGAV VGVQPFGGEG LSGTGPKAGG PHYLPRFCAE
1010
RTLTVNTAAA GGNVALLAG
Length:1,019
Mass (Da):107,556
Last modified:July 27, 2011 - v1
Checksum:i7F8D30BDE50E5C65
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000245 Genomic DNA Translation: AEG91515.1
RefSeqiWP_013899748.1, NC_015677.1

Genome annotation databases

EnsemblBacteriaiAEG91515; AEG91515; Rta_04440
KEGGirta:Rta_04440
PATRICifig|365046.3.peg.459

Similar proteinsi

Entry informationi

Entry nameiF5Y611_RAMTT
AccessioniPrimary (citable) accession number: F5Y611
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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