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F5XPH8

- F5XPH8_MICPN

UniProt

F5XPH8 - F5XPH8_MICPN

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Protein
Submitted name:

NADP(+)-dependent isocitrate dehydrogenase

Gene

icd

Organism
Microlunatus phosphovorus (strain ATCC 700054 / DSM 10555 / JCM 9379 / NBRC 101784 / NCIMB 13414 / VKM Ac-1990 / NM-1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei147 – 1471SubstrateUniRule annotation
Metal bindingi350 – 3501Magnesium or manganeseUniRule annotation
Sitei420 – 4201Critical for catalysisUniRule annotation
Binding sitei547 – 5471SubstrateUniRule annotation
Metal bindingi548 – 5481Magnesium or manganeseUniRule annotation
Metal bindingi552 – 5521Magnesium or manganeseUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciMPHO1032480:GHBY-1284-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
NADP(+)-dependent isocitrate dehydrogenaseImported (EC:1.1.1.42Imported)
Gene namesi
Name:icdImported
Ordered Locus Names:MLP_12720Imported
OrganismiMicrolunatus phosphovorus (strain ATCC 700054 / DSM 10555 / JCM 9379 / NBRC 101784 / NCIMB 13414 / VKM Ac-1990 / NM-1)Imported
Taxonomic identifieri1032480 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaeMicrolunatus
ProteomesiUP000007947: Chromosome

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 1418Substrate bindingUniRule annotation

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

F5XPH8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVQSSARIVY TRTDEAPLLA TYSLLPIIAA YAAKAGVDIE SRDISLAARI
60 70 80 90 100
LAQFPERLGA DQQVPDALAE LGALAKTPEA NIIKLPNISA SIPQLKAAIR
110 120 130 140 150
ELQEKGFDLP DYPDDPKSDE DRSIRARYDK VKGSAVNPVL REGNSDRRAP
160 170 180 190 200
LSVKNYARKH PHRMGAWSGD SKTNVAHMTA DDFRSNEKSV VIPADTSLRI
210 220 230 240 250
ALVEEAGAET VLRESVPVLA GEVVDATVLR VAALRAFLTE QIARAKAENV
260 270 280 290 300
LLSVHLKATM MKVSDPIIFG HAVRAFFPEV FETYGDALAT AGLSPNDGLG
310 320 330 340 350
AILAGLDALP EGPEIKAAID RGFAEGPALA MVDSDRGISN LHVPSDVIVD
360 370 380 390 400
ASMPAMIRTS GHMWGPDGAE ADTLAVLPDS SYAPIYQVVI DDCRANGAFD
410 420 430 440 450
PATMGSVPNV GLMAQAAEEY GSHDKTFEIP AEGVVKVTDS EGNVVLEHRV
460 470 480 490 500
SQGDIWRMCQ AKDVPIRDWI KLAVSRARAT GSPAVFWLDE TRAHDANLIA
510 520 530 540 550
KINETLPEYD TDGLEIKILS PADAMAYSLE RIRRGEDTIS VTGNVLRDYL
560 570 580 590 600
TDLFPIMELG TSAKMLSVVP LINGGGLFET GAGGSAPKHV QQLLKEDYLR
610 620 630 640 650
WDSLGEFLAL AVSLEHLAQS TGNKRAQVLA DTLDRATGTF LDENKSPARR
660 670 680 690 700
VGSIDNRGSH FYLALYWAEE LAAQTDDAEL AAEFATLAAA LREQEQTISD
710 720 730 740
ELIAVQGAPV DIGGYYRPDD DLTSAVMRPS ATFNAAIAAL
Length:740
Mass (Da):79,570
Last modified:July 27, 2011 - v1
Checksum:iFF530C866D0676D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012204 Genomic DNA. Translation: BAK34286.1.
RefSeqiYP_004571689.1. NC_015635.1.

Genome annotation databases

EnsemblBacteriaiBAK34286; BAK34286; MLP_12720.
GeneIDi10767775.
KEGGimph:MLP_12720.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012204 Genomic DNA. Translation: BAK34286.1 .
RefSeqi YP_004571689.1. NC_015635.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAK34286 ; BAK34286 ; MLP_12720 .
GeneIDi 10767775.
KEGGi mph:MLP_12720.

Phylogenomic databases

KOi K00031.

Enzyme and pathway databases

BioCyci MPHO1032480:GHBY-1284-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Whole genome sequence of Microlunatus phosphovorus NM-1."
    Hosoyama A., Sasaki K., Harada T., Igarashi R., Kawakoshi A., Sasagawa M., Fukada J., Nakamura S., Katano Y., Hanada S., Kamagata Y., Nakamura N., Yamazaki S., Fujita N.
    Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700054 / DSM 10555 / JCM 9379 / NBRC 101784 / NCIMB 13414 / VKM Ac-1990 / NM-1Imported.

Entry informationi

Entry nameiF5XPH8_MICPN
AccessioniPrimary (citable) accession number: F5XPH8
Entry historyi
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3