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F5XPH8

- F5XPH8_MICPN

UniProt

F5XPH8 - F5XPH8_MICPN

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Protein
Submitted name: NADP(+)-dependent isocitrate dehydrogenase
Gene
icd, MLP_12720
Organism
Microlunatus phosphovorus (strain ATCC 700054 / DSM 10555 / JCM 9379 / NBRC 101784 / NCIMB 13414 / VKM Ac-1990 / NM-1)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei147 – 1471Substrate By similarityUniRule annotation
Sitei257 – 2571Critical for catalysis By similarityUniRule annotation
Metal bindingi350 – 3501Magnesium or manganese By similarity
Sitei420 – 4201Critical for catalysis By similarityUniRule annotation
Binding sitei547 – 5471Substrate By similarityUniRule annotation
Metal bindingi548 – 5481Magnesium or manganese By similarity
Metal bindingi552 – 5521Magnesium or manganese By similarity

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciMPHO1032480:GHBY-1284-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
NADP(+)-dependent isocitrate dehydrogenaseImported (EC:1.1.1.42Imported)
Gene namesi
Name:icdImported
Ordered Locus Names:MLP_12720Imported
OrganismiMicrolunatus phosphovorus (strain ATCC 700054 / DSM 10555 / JCM 9379 / NBRC 101784 / NCIMB 13414 / VKM Ac-1990 / NM-1)Imported
Taxonomic identifieri1032480 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaeMicrolunatus
ProteomesiUP000007947: Chromosome

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 1418Substrate binding By similarityUniRule annotation

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

F5XPH8-1 [UniParc]FASTAAdd to Basket

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MVQSSARIVY TRTDEAPLLA TYSLLPIIAA YAAKAGVDIE SRDISLAARI    50
LAQFPERLGA DQQVPDALAE LGALAKTPEA NIIKLPNISA SIPQLKAAIR 100
ELQEKGFDLP DYPDDPKSDE DRSIRARYDK VKGSAVNPVL REGNSDRRAP 150
LSVKNYARKH PHRMGAWSGD SKTNVAHMTA DDFRSNEKSV VIPADTSLRI 200
ALVEEAGAET VLRESVPVLA GEVVDATVLR VAALRAFLTE QIARAKAENV 250
LLSVHLKATM MKVSDPIIFG HAVRAFFPEV FETYGDALAT AGLSPNDGLG 300
AILAGLDALP EGPEIKAAID RGFAEGPALA MVDSDRGISN LHVPSDVIVD 350
ASMPAMIRTS GHMWGPDGAE ADTLAVLPDS SYAPIYQVVI DDCRANGAFD 400
PATMGSVPNV GLMAQAAEEY GSHDKTFEIP AEGVVKVTDS EGNVVLEHRV 450
SQGDIWRMCQ AKDVPIRDWI KLAVSRARAT GSPAVFWLDE TRAHDANLIA 500
KINETLPEYD TDGLEIKILS PADAMAYSLE RIRRGEDTIS VTGNVLRDYL 550
TDLFPIMELG TSAKMLSVVP LINGGGLFET GAGGSAPKHV QQLLKEDYLR 600
WDSLGEFLAL AVSLEHLAQS TGNKRAQVLA DTLDRATGTF LDENKSPARR 650
VGSIDNRGSH FYLALYWAEE LAAQTDDAEL AAEFATLAAA LREQEQTISD 700
ELIAVQGAPV DIGGYYRPDD DLTSAVMRPS ATFNAAIAAL 740
Length:740
Mass (Da):79,570
Last modified:July 27, 2011 - v1
Checksum:iFF530C866D0676D7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP012204 Genomic DNA. Translation: BAK34286.1.
RefSeqiWP_013862169.1. NC_015635.1.
YP_004571689.1. NC_015635.1.

Genome annotation databases

EnsemblBacteriaiBAK34286; BAK34286; MLP_12720.
GeneIDi10767775.
KEGGimph:MLP_12720.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP012204 Genomic DNA. Translation: BAK34286.1 .
RefSeqi WP_013862169.1. NC_015635.1.
YP_004571689.1. NC_015635.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAK34286 ; BAK34286 ; MLP_12720 .
GeneIDi 10767775.
KEGGi mph:MLP_12720.

Phylogenomic databases

KOi K00031.

Enzyme and pathway databases

BioCyci MPHO1032480:GHBY-1284-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Whole genome sequence of Microlunatus phosphovorus NM-1."
    Hosoyama A., Sasaki K., Harada T., Igarashi R., Kawakoshi A., Sasagawa M., Fukada J., Nakamura S., Katano Y., Hanada S., Kamagata Y., Nakamura N., Yamazaki S., Fujita N.
    Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700054 / DSM 10555 / JCM 9379 / NBRC 101784 / NCIMB 13414 / VKM Ac-1990 / NM-1.

Entry informationi

Entry nameiF5XPH8_MICPN
AccessioniPrimary (citable) accession number: F5XPH8
Entry historyi
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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