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Protein
Submitted name:

NADP(+)-dependent isocitrate dehydrogenase

Gene

icd

Organism
Microlunatus phosphovorus (strain ATCC 700054 / DSM 10555 / JCM 9379 / NBRC 101784 / NCIMB 13414 / VKM Ac-1990 / NM-1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei147 – 1471SubstrateUniRule annotation
Sitei257 – 2571Critical for catalysisUniRule annotation
Metal bindingi350 – 3501Magnesium or manganeseUniRule annotation
Sitei420 – 4201Critical for catalysisUniRule annotation
Binding sitei547 – 5471SubstrateUniRule annotation
Metal bindingi548 – 5481Magnesium or manganeseUniRule annotation
Metal bindingi552 – 5521Magnesium or manganeseUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciMPHO1032480:GHBY-1284-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
NADP(+)-dependent isocitrate dehydrogenaseImported (EC:1.1.1.42Imported)
Gene namesi
Name:icdImported
Ordered Locus Names:MLP_12720Imported
OrganismiMicrolunatus phosphovorus (strain ATCC 700054 / DSM 10555 / JCM 9379 / NBRC 101784 / NCIMB 13414 / VKM Ac-1990 / NM-1)Imported
Taxonomic identifieri1032480 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPropionibacterialesPropionibacteriaceaeMicrolunatus
ProteomesiUP000007947 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi1032480.MLP_12720.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 1418Substrate bindingUniRule annotation

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

F5XPH8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQSSARIVY TRTDEAPLLA TYSLLPIIAA YAAKAGVDIE SRDISLAARI
60 70 80 90 100
LAQFPERLGA DQQVPDALAE LGALAKTPEA NIIKLPNISA SIPQLKAAIR
110 120 130 140 150
ELQEKGFDLP DYPDDPKSDE DRSIRARYDK VKGSAVNPVL REGNSDRRAP
160 170 180 190 200
LSVKNYARKH PHRMGAWSGD SKTNVAHMTA DDFRSNEKSV VIPADTSLRI
210 220 230 240 250
ALVEEAGAET VLRESVPVLA GEVVDATVLR VAALRAFLTE QIARAKAENV
260 270 280 290 300
LLSVHLKATM MKVSDPIIFG HAVRAFFPEV FETYGDALAT AGLSPNDGLG
310 320 330 340 350
AILAGLDALP EGPEIKAAID RGFAEGPALA MVDSDRGISN LHVPSDVIVD
360 370 380 390 400
ASMPAMIRTS GHMWGPDGAE ADTLAVLPDS SYAPIYQVVI DDCRANGAFD
410 420 430 440 450
PATMGSVPNV GLMAQAAEEY GSHDKTFEIP AEGVVKVTDS EGNVVLEHRV
460 470 480 490 500
SQGDIWRMCQ AKDVPIRDWI KLAVSRARAT GSPAVFWLDE TRAHDANLIA
510 520 530 540 550
KINETLPEYD TDGLEIKILS PADAMAYSLE RIRRGEDTIS VTGNVLRDYL
560 570 580 590 600
TDLFPIMELG TSAKMLSVVP LINGGGLFET GAGGSAPKHV QQLLKEDYLR
610 620 630 640 650
WDSLGEFLAL AVSLEHLAQS TGNKRAQVLA DTLDRATGTF LDENKSPARR
660 670 680 690 700
VGSIDNRGSH FYLALYWAEE LAAQTDDAEL AAEFATLAAA LREQEQTISD
710 720 730 740
ELIAVQGAPV DIGGYYRPDD DLTSAVMRPS ATFNAAIAAL
Length:740
Mass (Da):79,570
Last modified:July 27, 2011 - v1
Checksum:iFF530C866D0676D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012204 Genomic DNA. Translation: BAK34286.1.
RefSeqiWP_013862169.1. NC_015635.1.
YP_004571689.1. NC_015635.1.

Genome annotation databases

EnsemblBacteriaiBAK34286; BAK34286; MLP_12720.
KEGGimph:MLP_12720.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012204 Genomic DNA. Translation: BAK34286.1.
RefSeqiWP_013862169.1. NC_015635.1.
YP_004571689.1. NC_015635.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi1032480.MLP_12720.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAK34286; BAK34286; MLP_12720.
KEGGimph:MLP_12720.

Phylogenomic databases

KOiK00031.

Enzyme and pathway databases

BioCyciMPHO1032480:GHBY-1284-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Whole genome sequence of Microlunatus phosphovorus NM-1."
    Hosoyama A., Sasaki K., Harada T., Igarashi R., Kawakoshi A., Sasagawa M., Fukada J., Nakamura S., Katano Y., Hanada S., Kamagata Y., Nakamura N., Yamazaki S., Fujita N.
    Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700054 / DSM 10555 / JCM 9379 / NBRC 101784 / NCIMB 13414 / VKM Ac-1990 / NM-1Imported.

Entry informationi

Entry nameiF5XPH8_MICPN
AccessioniPrimary (citable) accession number: F5XPH8
Entry historyi
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: June 24, 2015
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.