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F5XPH8

- F5XPH8_MICPN

UniProt

F5XPH8 - F5XPH8_MICPN

Protein
Submitted name:

NADP(+)-dependent isocitrate dehydrogenase

Gene

icd

Organism
Microlunatus phosphovorus (strain ATCC 700054 / DSM 10555 / JCM 9379 / NBRC 101784 / NCIMB 13414 / VKM Ac-1990 / NM-1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 18 (01 Oct 2014)
      Sequence version 1 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei147 – 1471SubstrateUniRule annotation
    Sitei257 – 2571Critical for catalysis
    Metal bindingi350 – 3501Magnesium or manganeseUniRule annotation
    Sitei420 – 4201Critical for catalysisUniRule annotation
    Binding sitei547 – 5471SubstrateUniRule annotation
    Metal bindingi548 – 5481Magnesium or manganeseUniRule annotation
    Metal bindingi552 – 5521Magnesium or manganeseUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseImported

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciMPHO1032480:GHBY-1284-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    NADP(+)-dependent isocitrate dehydrogenaseImported (EC:1.1.1.42Imported)
    Gene namesi
    Name:icdImported
    Ordered Locus Names:MLP_12720Imported
    OrganismiMicrolunatus phosphovorus (strain ATCC 700054 / DSM 10555 / JCM 9379 / NBRC 101784 / NCIMB 13414 / VKM Ac-1990 / NM-1)Imported
    Taxonomic identifieri1032480 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaeMicrolunatus
    ProteomesiUP000007947: Chromosome

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni134 – 1418Substrate bindingUniRule annotation

    Phylogenomic databases

    KOiK00031.

    Family and domain databases

    Gene3Di3.40.718.10. 3 hits.
    InterProiIPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PfamiPF03971. IDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    F5XPH8-1 [UniParc]FASTAAdd to Basket

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    MVQSSARIVY TRTDEAPLLA TYSLLPIIAA YAAKAGVDIE SRDISLAARI    50
    LAQFPERLGA DQQVPDALAE LGALAKTPEA NIIKLPNISA SIPQLKAAIR 100
    ELQEKGFDLP DYPDDPKSDE DRSIRARYDK VKGSAVNPVL REGNSDRRAP 150
    LSVKNYARKH PHRMGAWSGD SKTNVAHMTA DDFRSNEKSV VIPADTSLRI 200
    ALVEEAGAET VLRESVPVLA GEVVDATVLR VAALRAFLTE QIARAKAENV 250
    LLSVHLKATM MKVSDPIIFG HAVRAFFPEV FETYGDALAT AGLSPNDGLG 300
    AILAGLDALP EGPEIKAAID RGFAEGPALA MVDSDRGISN LHVPSDVIVD 350
    ASMPAMIRTS GHMWGPDGAE ADTLAVLPDS SYAPIYQVVI DDCRANGAFD 400
    PATMGSVPNV GLMAQAAEEY GSHDKTFEIP AEGVVKVTDS EGNVVLEHRV 450
    SQGDIWRMCQ AKDVPIRDWI KLAVSRARAT GSPAVFWLDE TRAHDANLIA 500
    KINETLPEYD TDGLEIKILS PADAMAYSLE RIRRGEDTIS VTGNVLRDYL 550
    TDLFPIMELG TSAKMLSVVP LINGGGLFET GAGGSAPKHV QQLLKEDYLR 600
    WDSLGEFLAL AVSLEHLAQS TGNKRAQVLA DTLDRATGTF LDENKSPARR 650
    VGSIDNRGSH FYLALYWAEE LAAQTDDAEL AAEFATLAAA LREQEQTISD 700
    ELIAVQGAPV DIGGYYRPDD DLTSAVMRPS ATFNAAIAAL 740
    Length:740
    Mass (Da):79,570
    Last modified:July 27, 2011 - v1
    Checksum:iFF530C866D0676D7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP012204 Genomic DNA. Translation: BAK34286.1.
    RefSeqiWP_013862169.1. NC_015635.1.
    YP_004571689.1. NC_015635.1.

    Genome annotation databases

    EnsemblBacteriaiBAK34286; BAK34286; MLP_12720.
    GeneIDi10767775.
    KEGGimph:MLP_12720.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP012204 Genomic DNA. Translation: BAK34286.1 .
    RefSeqi WP_013862169.1. NC_015635.1.
    YP_004571689.1. NC_015635.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAK34286 ; BAK34286 ; MLP_12720 .
    GeneIDi 10767775.
    KEGGi mph:MLP_12720.

    Phylogenomic databases

    KOi K00031.

    Enzyme and pathway databases

    BioCyci MPHO1032480:GHBY-1284-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 3 hits.
    InterProi IPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    Pfami PF03971. IDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Whole genome sequence of Microlunatus phosphovorus NM-1."
      Hosoyama A., Sasaki K., Harada T., Igarashi R., Kawakoshi A., Sasagawa M., Fukada J., Nakamura S., Katano Y., Hanada S., Kamagata Y., Nakamura N., Yamazaki S., Fujita N.
      Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700054 / DSM 10555 / JCM 9379 / NBRC 101784 / NCIMB 13414 / VKM Ac-1990 / NM-1Imported.

    Entry informationi

    Entry nameiF5XPH8_MICPN
    AccessioniPrimary (citable) accession number: F5XPH8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 27, 2011
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 18 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3