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F5XKZ6

- F5XKZ6_MICPN

UniProt

F5XKZ6 - F5XKZ6_MICPN

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Protein

Adenylosuccinate lyase

Gene

purB

Organism
Microlunatus phosphovorus (strain ATCC 700054 / DSM 10555 / JCM 9379 / NBRC 101784 / NCIMB 13414 / VKM Ac-1990 / NM-1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
N(6)-(1,2-dicarboxyethyl)AMP = fumarate + AMP.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity Source: UniProtKB-EC
  2. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' AMP biosynthetic process Source: UniProtKB-UniPathway
  2. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationImported

Keywords - Biological processi

Purine biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciMPHO1032480:GHBY-674-MONOMER.
UniPathwayiUPA00074; UER00132.
UPA00075; UER00336.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylosuccinate lyaseUniRule annotation (EC:4.3.2.2UniRule annotation)
Short name:
ASLUniRule annotation
Alternative name(s):
AdenylosuccinaseUniRule annotation
Gene namesi
Name:purBImported
Ordered Locus Names:MLP_06700Imported
OrganismiMicrolunatus phosphovorus (strain ATCC 700054 / DSM 10555 / JCM 9379 / NBRC 101784 / NCIMB 13414 / VKM Ac-1990 / NM-1)Imported
Taxonomic identifieri1032480 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaeMicrolunatus
ProteomesiUP000007947: Chromosome

Structurei

3D structure databases

ProteinModelPortaliF5XKZ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

KOiK01756.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
InterProiIPR019468. AdenyloSucc_lyase_C.
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
IPR004769. Pur_lyase.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PfamiPF10397. ADSL_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SMARTiSM00998. ADSL_C. 1 hit.
[Graphical view]
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00928. purB. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F5XKZ6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSVPNVLANR YASQQLRTVW SPENKIVAER LLWIAVLSAQ RDLGVDFGGD
60 70 80 90 100
DPDAVISAYT AQVEKVDLAS IAAREKITRH DVKARIEEFN ALAGYEHVHK
110 120 130 140 150
GMTSRDLTEN VEQLQIHSSL KIIRDRLVAS LVQLARLGAT YADQPIAGRS
160 170 180 190 200
HNVAAQITTL GKRFATAADE QLIAYRRVCE LIDRYPLRGI KGPVGTGQDM
210 220 230 240 250
LDLLGGDAAK LADLERLVAA HLGVPTILTS TGQVYPRSLD FDVVTALAQA
260 270 280 290 300
AAAPSNVATS IRLMAGHELV TEGFRPGQVG SSAMPHKMNT RSCERVNGLA
310 320 330 340 350
VIVRGYVSMV GELAGDQWNE GDVSCSVVRR VALPDAFYAL DGLFETFLTV
360 370 380 390 400
LGDFGAFPAV IEAELQRYLP FLTTTKVLMA AVRHGVGRET AHEAIKEHAV
410 420 430 440 450
AVALEMREKG LARNDLLDRL AADPRLGLTQ ADLETLVAEP LAMAGTAQAQ
460 470
VAAIVVEVEK IAAEHPAAAA YRPGDVL
Length:477
Mass (Da):51,373
Last modified:July 27, 2011 - v1
Checksum:i7421217004FECC8C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP012204 Genomic DNA. Translation: BAK33684.1.
RefSeqiWP_013861573.1. NC_015635.1.
YP_004571087.1. NC_015635.1.

Genome annotation databases

EnsemblBacteriaiBAK33684; BAK33684; MLP_06700.
GeneIDi10771838.
KEGGimph:MLP_06700.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP012204 Genomic DNA. Translation: BAK33684.1 .
RefSeqi WP_013861573.1. NC_015635.1.
YP_004571087.1. NC_015635.1.

3D structure databases

ProteinModelPortali F5XKZ6.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAK33684 ; BAK33684 ; MLP_06700 .
GeneIDi 10771838.
KEGGi mph:MLP_06700.

Phylogenomic databases

KOi K01756.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00132 .
UPA00075 ; UER00336 .
BioCyci MPHO1032480:GHBY-674-MONOMER.

Family and domain databases

Gene3Di 1.10.275.10. 1 hit.
InterProi IPR019468. AdenyloSucc_lyase_C.
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
IPR004769. Pur_lyase.
[Graphical view ]
PANTHERi PTHR11444. PTHR11444. 1 hit.
Pfami PF10397. ADSL_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view ]
PRINTSi PR00149. FUMRATELYASE.
SMARTi SM00998. ADSL_C. 1 hit.
[Graphical view ]
SUPFAMi SSF48557. SSF48557. 1 hit.
TIGRFAMsi TIGR00928. purB. 1 hit.
PROSITEi PS00163. FUMARATE_LYASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole genome sequence of Microlunatus phosphovorus NM-1."
    Hosoyama A., Sasaki K., Harada T., Igarashi R., Kawakoshi A., Sasagawa M., Fukada J., Nakamura S., Katano Y., Hanada S., Kamagata Y., Nakamura N., Yamazaki S., Fujita N.
    Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700054 / DSM 10555 / JCM 9379 / NBRC 101784 / NCIMB 13414 / VKM Ac-1990 / NM-1Imported.

Entry informationi

Entry nameiF5XKZ6_MICPN
AccessioniPrimary (citable) accession number: F5XKZ6
Entry historyi
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3