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F5X5N9 (F5X5N9_STRPX) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 16. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-isopropylmalate dehydratase small subunit HAMAP-Rule MF_01031
EC=4.2.1.33 HAMAP-Rule MF_01031
Alternative name(s):
Alpha-IPM isomerase HAMAP-Rule MF_01031
Isopropylmalate isomerase HAMAP-Rule MF_01031
Gene names
Name:leuD HAMAP-Rule MF_01031 EMBL BAK29729.1
Ordered Locus Names:SGPB_0633 EMBL BAK29729.1
OrganismStreptococcus pasteurianus (strain ATCC 43144 / JCM 5346 / CDC 1723-81) [Complete proteome] [HAMAP]
Taxonomic identifier981540 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus ›

Protein attributes

Sequence length196 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate By similarity. HAMAP-Rule MF_01031 SAAS SAAS004431

Catalytic activity

(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate. HAMAP-Rule MF_01031 SAAS SAAS004431

Pathway

Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4. HAMAP-Rule MF_01031 SAAS SAAS004431

Subunit structure

Heterodimer of LeuC and LeuD By similarity. HAMAP-Rule MF_01031

Sequence similarities

Belongs to the LeuD family. LeuD type 1 subfamily. HAMAP-Rule MF_01031

Sequences

Sequence LengthMass (Da)Tools
F5X5N9 [UniParc].

Last modified July 27, 2011. Version 1.
Checksum: D94EBFD1F717BCB9

FASTA19622,441
        10         20         30         40         50         60 
MEKFTVYIGK SVPLMNDNID TDQLIPKQFL KAVDKKGFGK NLLFEWRYLN DNYDENPDFI 

        70         80         90        100        110        120 
FNKPEYRHAT ILISGDNFGS GSSREHAAWA LEDYGFRCVI AGSFSDIHYN NELKNGMLPI 

       130        140        150        160        170        180 
VQPLEVRQKL AALPAGEEIT IDLPNQVIKS SAGEFPFEID GEWKRKLVLG LDDIGITLQY 

       190 
ENLIAAYEKN RPSYWQ

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References

[1]"Sequencing and comparative genome analysis of two pathogenic Streptococcus gallolyticus subspecies: genome plasticity, adaptation and virulence."
Lin I.-H., Liu T.-T., Teng Y.-T., Wu H.-L., Liu Y.-M., Wu K.-M., Chang C.-H., Hsu M.-T.
PLoS ONE 6:E20519-E20519(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43144 / JCM 5346 / CDC 1723-81.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP012054 Genomic DNA. Translation: BAK29729.1.
RefSeqYP_004558815.1. NC_015600.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAK29729; BAK29729; SGPB_0633.
GeneID10753666.
KEGGstb:SGPB_0633.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01704.

Enzyme and pathway databases

BioCycSPAS981540:GJYA-696-MONOMER.
UniPathwayUPA00048; UER00071.

Family and domain databases

Gene3D3.20.19.10. 1 hit.
HAMAPMF_01031. LeuD_type1.
InterProIPR004431. 3-IsopropMal_deHydase_ssu.
IPR015937. Acoase/IPM_deHydtase.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
[Graphical view]
PANTHERPTHR11670. PTHR11670. 1 hit.
PfamPF00694. Aconitase_C. 1 hit.
[Graphical view]
SUPFAMSSF52016. Aconitase/3IPM_dehydase_swvl. 1 hit.
TIGRFAMsTIGR00171. leuD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameF5X5N9_STRPX
AccessionPrimary (citable) accession number: F5X5N9
Entry history
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: May 29, 2013
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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