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Protein

3-isopropylmalate dehydratase small subunit

Gene

leuD

Organism
Streptococcus pasteurianus (strain ATCC 43144 / JCM 5346 / CDC 1723-81)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.UniRule annotationSAAS annotation

Catalytic activityi

(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate.UniRule annotationSAAS annotation

Pathwayi: L-leucine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-leucine from 3-methyl-2-oxobutanoate.UniRule annotationSAAS annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. 2-isopropylmalate synthase (leuA)
  2. 3-isopropylmalate dehydratase large subunit (leuC), 3-isopropylmalate dehydratase small subunit (leuD)
  3. 3-isopropylmalate dehydrogenase (leuB)
  4. Branched-chain-amino-acid aminotransferase (ilvE)
This subpathway is part of the pathway L-leucine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-leucine from 3-methyl-2-oxobutanoate, the pathway L-leucine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotationImported
Biological processAmino-acid biosynthesis, Branched-chain amino acid biosynthesis, Leucine biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00048; UER00071.

Names & Taxonomyi

Protein namesi
Recommended name:
3-isopropylmalate dehydratase small subunitUniRule annotation (EC:4.2.1.33UniRule annotation)
Alternative name(s):
Alpha-IPM isomeraseUniRule annotation
Short name:
IPMIUniRule annotation
Isopropylmalate isomeraseUniRule annotation
Gene namesi
Name:leuDUniRule annotationImported
Ordered Locus Names:SGPB_0633Imported
OrganismiStreptococcus pasteurianus (strain ATCC 43144 / JCM 5346 / CDC 1723-81)Imported
Taxonomic identifieri981540 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000007946 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Interactioni

Subunit structurei

Heterodimer of LeuC and LeuD.UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 122Aconitase_CInterPro annotationAdd BLAST122

Sequence similaritiesi

Belongs to the LeuD family. LeuD type 1 subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK01704.
OMAiAFTTHTG.

Family and domain databases

CDDicd01577. IPMI_Swivel. 1 hit.
Gene3Di3.20.19.10. 1 hit.
HAMAPiMF_01031. LeuD_type1. 1 hit.
InterProiView protein in InterPro
IPR004431. 3-IsopropMal_deHydase_ssu.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
IPR033940. IPMI_Swivel.
PfamiView protein in Pfam
PF00694. Aconitase_C. 1 hit.
SUPFAMiSSF52016. SSF52016. 1 hit.
TIGRFAMsiTIGR00171. leuD. 1 hit.

Sequencei

Sequence statusi: Complete.

F5X5N9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKFTVYIGK SVPLMNDNID TDQLIPKQFL KAVDKKGFGK NLLFEWRYLN
60 70 80 90 100
DNYDENPDFI FNKPEYRHAT ILISGDNFGS GSSREHAAWA LEDYGFRCVI
110 120 130 140 150
AGSFSDIHYN NELKNGMLPI VQPLEVRQKL AALPAGEEIT IDLPNQVIKS
160 170 180 190
SAGEFPFEID GEWKRKLVLG LDDIGITLQY ENLIAAYEKN RPSYWQ
Length:196
Mass (Da):22,441
Last modified:July 27, 2011 - v1
Checksum:iD94EBFD1F717BCB9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012054 Genomic DNA. Translation: BAK29729.1.
RefSeqiWP_013851650.1. NC_015600.1.

Genome annotation databases

EnsemblBacteriaiBAK29729; BAK29729; SGPB_0633.
KEGGistb:SGPB_0633.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiF5X5N9_STRPX
AccessioniPrimary (citable) accession number: F5X5N9
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: June 7, 2017
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported