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F5X5N9

- F5X5N9_STRPX

UniProt

F5X5N9 - F5X5N9_STRPX

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Protein
3-isopropylmalate dehydratase small subunit
Gene
leuD, SGPB_0633
Organism
Streptococcus pasteurianus (strain ATCC 43144 / JCM 5346 / CDC 1723-81)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate By similarity.UniRule annotationSAAS annotations

Catalytic activityi

(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate.UniRule annotationSAAS annotations

Pathwayi

GO - Molecular functioni

  1. 3-isopropylmalate dehydratase activity Source: UniProtKB-EC

GO - Biological processi

  1. leucine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesis, Leucine biosynthesisUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciSPAS981540:GJYA-696-MONOMER.
UniPathwayiUPA00048; UER00071.

Names & Taxonomyi

Protein namesi
Recommended name:
3-isopropylmalate dehydratase small subunitUniRule annotation (EC:4.2.1.33UniRule annotation)
Alternative name(s):
Alpha-IPM isomerase
Isopropylmalate isomerase
Gene namesi
Name:leuDUniRule annotationImported
Ordered Locus Names:SGPB_0633Imported
OrganismiStreptococcus pasteurianus (strain ATCC 43144 / JCM 5346 / CDC 1723-81)
Taxonomic identifieri981540 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000007946: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. 3-isopropylmalate dehydratase complex Source: InterPro
Complete GO annotation...

Interactioni

Subunit structurei

Heterodimer of LeuC and LeuD By similarity.UniRule annotationSAAS annotations

Family & Domainsi

Sequence similaritiesi

Belongs to the LeuD family. LeuD type 1 subfamily.UniRule annotation

Phylogenomic databases

KOiK01704.
OMAiNWRFLEN.

Family and domain databases

Gene3Di3.20.19.10. 1 hit.
HAMAPiMF_01031. LeuD_type1.
InterProiIPR004431. 3-IsopropMal_deHydase_ssu.
IPR015937. Acoase/IPM_deHydtase.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
[Graphical view]
PANTHERiPTHR11670. PTHR11670. 1 hit.
PfamiPF00694. Aconitase_C. 1 hit.
[Graphical view]
SUPFAMiSSF52016. SSF52016. 1 hit.
TIGRFAMsiTIGR00171. leuD. 1 hit.

Sequencei

Sequence statusi: Complete.

F5X5N9-1 [UniParc]FASTAAdd to Basket

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MEKFTVYIGK SVPLMNDNID TDQLIPKQFL KAVDKKGFGK NLLFEWRYLN    50
DNYDENPDFI FNKPEYRHAT ILISGDNFGS GSSREHAAWA LEDYGFRCVI 100
AGSFSDIHYN NELKNGMLPI VQPLEVRQKL AALPAGEEIT IDLPNQVIKS 150
SAGEFPFEID GEWKRKLVLG LDDIGITLQY ENLIAAYEKN RPSYWQ 196
Length:196
Mass (Da):22,441
Last modified:July 27, 2011 - v1
Checksum:iD94EBFD1F717BCB9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP012054 Genomic DNA. Translation: BAK29729.1.
RefSeqiYP_004558815.1. NC_015600.1.

Genome annotation databases

EnsemblBacteriaiBAK29729; BAK29729; SGPB_0633.
GeneIDi10753666.
KEGGistb:SGPB_0633.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP012054 Genomic DNA. Translation: BAK29729.1 .
RefSeqi YP_004558815.1. NC_015600.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAK29729 ; BAK29729 ; SGPB_0633 .
GeneIDi 10753666.
KEGGi stb:SGPB_0633.

Phylogenomic databases

KOi K01704.
OMAi NWRFLEN.

Enzyme and pathway databases

UniPathwayi UPA00048 ; UER00071 .
BioCyci SPAS981540:GJYA-696-MONOMER.

Family and domain databases

Gene3Di 3.20.19.10. 1 hit.
HAMAPi MF_01031. LeuD_type1.
InterProi IPR004431. 3-IsopropMal_deHydase_ssu.
IPR015937. Acoase/IPM_deHydtase.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
[Graphical view ]
PANTHERi PTHR11670. PTHR11670. 1 hit.
Pfami PF00694. Aconitase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF52016. SSF52016. 1 hit.
TIGRFAMsi TIGR00171. leuD. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Sequencing and comparative genome analysis of two pathogenic Streptococcus gallolyticus subspecies: genome plasticity, adaptation and virulence."
    Lin I.-H., Liu T.-T., Teng Y.-T., Wu H.-L., Liu Y.-M., Wu K.-M., Chang C.-H., Hsu M.-T.
    PLoS ONE 6:E20519-E20519(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43144 / JCM 5346 / CDC 1723-81.

Entry informationi

Entry nameiF5X5N9_STRPX
AccessioniPrimary (citable) accession number: F5X5N9
Entry historyi
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: May 14, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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