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F5X5N9

- F5X5N9_STRPX

UniProt

F5X5N9 - F5X5N9_STRPX

Protein

3-isopropylmalate dehydratase small subunit

Gene

leuD

Organism
Streptococcus pasteurianus (strain ATCC 43144 / JCM 5346 / CDC 1723-81)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.UniRule annotationSAAS annotation

    Catalytic activityi

    (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate.UniRule annotationSAAS annotation

    Pathwayi

    GO - Molecular functioni

    1. 3-isopropylmalate dehydratase activity Source: UniProtKB-EC

    GO - Biological processi

    1. leucine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    LyaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Amino-acid biosynthesis, Branched-chain amino acid biosynthesis, Leucine biosynthesisUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciSPAS981540:GJYA-696-MONOMER.
    UniPathwayiUPA00048; UER00071.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-isopropylmalate dehydratase small subunitUniRule annotation (EC:4.2.1.33UniRule annotation)
    Alternative name(s):
    Alpha-IPM isomeraseUniRule annotation
    Isopropylmalate isomeraseUniRule annotation
    Gene namesi
    Name:leuDUniRule annotationImported
    Ordered Locus Names:SGPB_0633Imported
    OrganismiStreptococcus pasteurianus (strain ATCC 43144 / JCM 5346 / CDC 1723-81)Imported
    Taxonomic identifieri981540 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000007946: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. 3-isopropylmalate dehydratase complex Source: InterPro

    Interactioni

    Subunit structurei

    Heterodimer of LeuC and LeuD.UniRule annotationSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LeuD family. LeuD type 1 subfamily.UniRule annotation

    Phylogenomic databases

    KOiK01704.
    OMAiNWRFLEN.

    Family and domain databases

    Gene3Di3.20.19.10. 1 hit.
    HAMAPiMF_01031. LeuD_type1.
    InterProiIPR004431. 3-IsopropMal_deHydase_ssu.
    IPR015937. Acoase/IPM_deHydtase.
    IPR015928. Aconitase/3IPM_dehydase_swvl.
    IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
    [Graphical view]
    PANTHERiPTHR11670. PTHR11670. 1 hit.
    PfamiPF00694. Aconitase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF52016. SSF52016. 1 hit.
    TIGRFAMsiTIGR00171. leuD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    F5X5N9-1 [UniParc]FASTAAdd to Basket

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    MEKFTVYIGK SVPLMNDNID TDQLIPKQFL KAVDKKGFGK NLLFEWRYLN    50
    DNYDENPDFI FNKPEYRHAT ILISGDNFGS GSSREHAAWA LEDYGFRCVI 100
    AGSFSDIHYN NELKNGMLPI VQPLEVRQKL AALPAGEEIT IDLPNQVIKS 150
    SAGEFPFEID GEWKRKLVLG LDDIGITLQY ENLIAAYEKN RPSYWQ 196
    Length:196
    Mass (Da):22,441
    Last modified:July 27, 2011 - v1
    Checksum:iD94EBFD1F717BCB9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP012054 Genomic DNA. Translation: BAK29729.1.
    RefSeqiYP_004558815.1. NC_015600.1.

    Genome annotation databases

    EnsemblBacteriaiBAK29729; BAK29729; SGPB_0633.
    GeneIDi10753666.
    KEGGistb:SGPB_0633.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP012054 Genomic DNA. Translation: BAK29729.1 .
    RefSeqi YP_004558815.1. NC_015600.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAK29729 ; BAK29729 ; SGPB_0633 .
    GeneIDi 10753666.
    KEGGi stb:SGPB_0633.

    Phylogenomic databases

    KOi K01704.
    OMAi NWRFLEN.

    Enzyme and pathway databases

    UniPathwayi UPA00048 ; UER00071 .
    BioCyci SPAS981540:GJYA-696-MONOMER.

    Family and domain databases

    Gene3Di 3.20.19.10. 1 hit.
    HAMAPi MF_01031. LeuD_type1.
    InterProi IPR004431. 3-IsopropMal_deHydase_ssu.
    IPR015937. Acoase/IPM_deHydtase.
    IPR015928. Aconitase/3IPM_dehydase_swvl.
    IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
    [Graphical view ]
    PANTHERi PTHR11670. PTHR11670. 1 hit.
    Pfami PF00694. Aconitase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52016. SSF52016. 1 hit.
    TIGRFAMsi TIGR00171. leuD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequencing and comparative genome analysis of two pathogenic Streptococcus gallolyticus subspecies: genome plasticity, adaptation and virulence."
      Lin I.-H., Liu T.-T., Teng Y.-T., Wu H.-L., Liu Y.-M., Wu K.-M., Chang C.-H., Hsu M.-T.
      PLoS ONE 6:E20519-E20519(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43144 / JCM 5346 / CDC 1723-81Imported.

    Entry informationi

    Entry nameiF5X5N9_STRPX
    AccessioniPrimary (citable) accession number: F5X5N9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 27, 2011
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3