F5X0T2 (F5X0T2_STRG1) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Thymidine kinase RuleBase RU000544 HAMAP-Rule MF_00124
EC=2.7.1.21 RuleBase RU000544 HAMAP-Rule MF_00124

Gene names

Name:	tdk HAMAP-Rule MF_00124 EMBL BAK27893.1
Ordered Locus Names:	SGGB_1024 EMBL BAK27893.1

Organism

Streptococcus gallolyticus (strain ATCC 43143 / F-1867) [Complete proteome] [HAMAP]

Taxonomic identifier

981539 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus gallolyticus › Streptococcus gallolyticus

Protein attributes

Sequence length	196 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + thymidine = ADP + thymidine 5'-phosphate. HAMAP-Rule MF_00124
Subunit structure	Homotetramer By similarity. HAMAP-Rule MF_00124 SAAS SAAS020633
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00124 SAAS SAAS020633.
Sequence similarities	Belongs to the thymidine kinase family. HAMAP-Rule MF_00124 RuleBase RU004165

Ontologies

Keywords
Biological process	DNA synthesis RuleBase RU000544 HAMAP-Rule MF_00124 SAAS SAAS020634
Cellular component	Cytoplasm HAMAP-Rule MF_00124 SAAS SAAS020633
Ligand	ATP-binding RuleBase RU000544 HAMAP-Rule MF_00124 SAAS SAAS020634 Metal-binding HAMAP-Rule MF_00124 SAAS SAAS020633 Nucleotide-binding Zinc HAMAP-Rule MF_00124 SAAS SAAS020633
Molecular function	Kinase RuleBase RU000544 HAMAP-Rule MF_00124 SAAS SAAS020634 EMBL BAK27893.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-HAMAP thymidine kinase activity Inferred from electronic annotation. Source: UniProtKB-HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	12 – 19	8	ATP By similarity HAMAP-Rule MF_00124
	Nucleotide binding	88 – 91	4	ATP By similarity HAMAP-Rule MF_00124
Sites
	Active site	89	1	Proton acceptor By similarity HAMAP-Rule MF_00124
	Metal binding	146	1	Zinc By similarity HAMAP-Rule MF_00124
	Metal binding	149	1	Zinc By similarity HAMAP-Rule MF_00124
	Metal binding	183	1	Zinc By similarity HAMAP-Rule MF_00124
	Metal binding	186	1	Zinc By similarity HAMAP-Rule MF_00124

Sequences

	Sequence		Length	Mass (Da)
	F5X0T2 [UniParc]. Last modified July 27, 2011. Version 1. Checksum: B5D7DB107ED7DE9B	FASTA	196	22,413
	10 20 30 40 50 60 MSLLAQLYYK YGTMNSGKTI EILKVAHNYE EQGKPVVIMT SALDTRDGYG VVSSRIGMRR 70 80 90 100 110 120 KAIAITEEMD IFAFIQELPE KPYCVLIDEC QFLTKKHVYD LARVVDDLDV PVMAFGLKND 130 140 150 160 170 180 FQNELFEGSK YLLLLADKID EIKTICQFCS KKATMVLRTE NGKPVYEGNQ IQIGGNETYI 190 PVCRKHYFNP MISKEK

References

[1]

"Sequencing and comparative genome analysis of two pathogenic Streptococcus gallolyticus subspecies: genome plasticity, adaptation and virulence." Lin I.-H., Liu T.-T., Teng Y.-T., Wu H.-L., Liu Y.-M., Wu K.-M., Chang C.-H., Hsu M.-T. PLoS ONE 6:E20519-E20519(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43143 / F-1867.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP012053 Genomic DNA. Translation: BAK27893.1.
RefSeq	YP_006033852.1. NC_017576.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAK27893; BAK27893; SGGB_1024.
GeneID	12630225.
KEGG	sgt:SGGB_1024.
Organism-specific databases
CMR	Search...
Phylogenomic databases
KO	K00857.
Enzyme and pathway databases
BioCyc	SGAL981539:GLL2-1091-MONOMER.
Family and domain databases
HAMAP	MF_00124. Thymidine_kinase.
InterPro	IPR027417. P-loop_NTPase. IPR001267. Thymidine_kinase. IPR020633. Thymidine_kinase_CS. IPR020634. Thymidine_kinase_subgr. [Graphical view]
PANTHER	PTHR11441. PTHR11441. 1 hit.
Pfam	PF00265. TK. 1 hit. [Graphical view]
PIRSF	PIRSF035805. TK_cell. 1 hit.
SUPFAM	SSF52540. SSF52540. 1 hit.
PROSITE	PS00603. TK_CELLULAR_TYPE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

F5X0T2_STRG1

Accession

Primary (citable) accession number: F5X0T2

Entry history

Integrated into UniProtKB/TrEMBL:	July 27, 2011
Last sequence update:	July 27, 2011
Last modified:	October 16, 2013
This is version 11 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)