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Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Streptococcus gallolyticus (strain ATCC 43143 / F-1867)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotationSAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 2 magnesium or manganese ions per subunit.UniRule annotation
  • Mn2+SAAS annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi288Magnesium or manganese 1UniRule annotation1
Metal bindingi301Magnesium or manganese 1UniRule annotation1
Metal bindingi301Magnesium or manganese 2UniRule annotation1
Metal bindingi303Magnesium or manganese 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported
Biological processCell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotationSAAS annotation (EC:6.3.2.4UniRule annotationSAAS annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlUniRule annotationImported
Ordered Locus Names:SGGB_0627Imported
OrganismiStreptococcus gallolyticus (strain ATCC 43143 / F-1867)Imported
Taxonomic identifieri981539 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000007945 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini132 – 334ATP-graspInterPro annotationAdd BLAST203

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK01921.
OMAiYETKYTE.
OrthoDBiPOG091H06GK.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig. 1 hit.
InterProiView protein in InterPro
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom_sf.
PfamiView protein in Pfam
PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
PIRSFiPIRSF039102. Ddl/VanB. 1 hit.
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEiView protein in PROSITE
PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

F5WZQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKETLVLLY GGRSAERKVS VLSAESVMRA INYDKFFVKT YFITQSGDFI
60 70 80 90 100
KTQEFSSKPA DDEKLMTNAT VVESQKIKPS DIYEEGAVVF PVLHGPMGED
110 120 130 140 150
GSIQGFLEIL KMPYVGTNIL SSSVAMDKIS TKHVLESAGV PLVAYVTYVE
160 170 180 190 200
GADLEKAVAE VNEKLTYPVF VKPANMGSSV GISKADDEEG LRSAIDLALK
210 220 230 240 250
YDSRILIETG VNAREIEVGI LGNADVQTTL PGEVVKDVAF YDYDAKYIDN
260 270 280 290 300
KITMDIPAHI DSSIMEEMRG YATTAFRAIG GCGLSRCDFF LTEDGHVYLN
310 320 330 340
ELNTMPGFTQ WSMYPLLWEN MGLAYSDLIE KLVELAKEMF EKRESHLI
Length:348
Mass (Da):38,526
Last modified:July 27, 2011 - v1
Checksum:i945C67654482B739
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012053 Genomic DNA. Translation: BAK27516.1.
RefSeqiWP_014619985.1. NC_017576.1.

Genome annotation databases

EnsemblBacteriaiBAK27516; BAK27516; SGGB_0627.
GeneIDi12629823.
KEGGisgt:SGGB_0627.
PATRICifig|981539.3.peg.625.

Similar proteinsi

Entry informationi

Entry nameiF5WZQ5_STRG1
AccessioniPrimary (citable) accession number: F5WZQ5
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: November 22, 2017
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported