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F5WZQ5 (F5WZQ5_STRG1) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 18. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047 EMBL BAK27516.1
Ordered Locus Names:SGGB_0627 EMBL BAK27516.1
OrganismStreptococcus gallolyticus (strain ATCC 43143 / F-1867) [Complete proteome] [HAMAP]
Taxonomic identifier981539 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length348 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain132 – 334203ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding162 – 21756ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2881Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3011Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3011Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3031Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
F5WZQ5 [UniParc].

Last modified July 27, 2011. Version 1.
Checksum: 945C67654482B739

FASTA34838,526
        10         20         30         40         50         60 
MAKETLVLLY GGRSAERKVS VLSAESVMRA INYDKFFVKT YFITQSGDFI KTQEFSSKPA 

        70         80         90        100        110        120 
DDEKLMTNAT VVESQKIKPS DIYEEGAVVF PVLHGPMGED GSIQGFLEIL KMPYVGTNIL 

       130        140        150        160        170        180 
SSSVAMDKIS TKHVLESAGV PLVAYVTYVE GADLEKAVAE VNEKLTYPVF VKPANMGSSV 

       190        200        210        220        230        240 
GISKADDEEG LRSAIDLALK YDSRILIETG VNAREIEVGI LGNADVQTTL PGEVVKDVAF 

       250        260        270        280        290        300 
YDYDAKYIDN KITMDIPAHI DSSIMEEMRG YATTAFRAIG GCGLSRCDFF LTEDGHVYLN 

       310        320        330        340 
ELNTMPGFTQ WSMYPLLWEN MGLAYSDLIE KLVELAKEMF EKRESHLI 

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References

[1]"Sequencing and comparative genome analysis of two pathogenic Streptococcus gallolyticus subspecies: genome plasticity, adaptation and virulence."
Lin I.-H., Liu T.-T., Teng Y.-T., Wu H.-L., Liu Y.-M., Wu K.-M., Chang C.-H., Hsu M.-T.
PLoS ONE 6:E20519-E20519(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43143 / F-1867.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP012053 Genomic DNA. Translation: BAK27516.1.
RefSeqYP_006033475.1. NC_017576.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAK27516; BAK27516; SGGB_0627.
GeneID12629823.
KEGGsgt:SGGB_0627.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.

Enzyme and pathway databases

BioCycSGAL981539:GLL2-690-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF5WZQ5_STRG1
AccessionPrimary (citable) accession number: F5WZQ5
Entry history
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: February 19, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)