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F5WWR9

- F5WWR9_STRG1

UniProt

F5WWR9 - F5WWR9_STRG1

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Protein

Alanine racemase

Gene

alr

Organism
Streptococcus gallolyticus (strain ATCC 43143 / F-1867)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Note: Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei40 – 401Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei136 – 1361SubstrateUniRule annotation
Active sitei263 – 2631Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei310 – 3101Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciSGAL981539:GLL2-1940-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:SGGB_1870Imported
OrganismiStreptococcus gallolyticus (strain ATCC 43143 / F-1867)Imported
Taxonomic identifieri981539 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000007945: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei40 – 401N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliF5WWR9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F5WWR9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MISSLHRPTK AVIDLDAICQ NIDAVKANIP QDKKAFAVVK ANAYGHGATS
60 70 80 90 100
VAQAIHHLVD GFCVSNIDEA LELREAGIEE TILILGVIMP DEVALARDYH
110 120 130 140 150
VTLTVASQEW LDLANEQGIS LAGLDVHLKV DSGMGRIGVR SLDEAENVIA
160 170 180 190 200
NLKKAGANVA GIFTHFATAD EADDTKFNEQ LEFFTNLVNN LSDKPAIVHA
210 220 230 240 250
SNSATSIWHS ETIFNLVRLG IVMYGLNPSG TELDLPYPLK PALSLESSLV
260 270 280 290 300
HVKTIPAGAT VGYGATYTAQ KEEYIATVPI GYADGWTRDL QGFSVLVNGE
310 320 330 340 350
FCEIVGRVSM DQITIRLPEK LPIGTKVTLI GQEGSKVISA TDLAQKRGTI
360
NYEVLCLLSD RIPRVYSK
Length:368
Mass (Da):39,738
Last modified:July 27, 2011 - v1
Checksum:i7E64C1DC37D58373
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012053 Genomic DNA. Translation: BAK28726.1.
RefSeqiWP_012962448.1. NC_017576.1.
YP_006034685.1. NC_017576.1.

Genome annotation databases

EnsemblBacteriaiBAK28726; BAK28726; SGGB_1870.
GeneIDi12631077.
KEGGisgt:SGGB_1870.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012053 Genomic DNA. Translation: BAK28726.1 .
RefSeqi WP_012962448.1. NC_017576.1.
YP_006034685.1. NC_017576.1.

3D structure databases

ProteinModelPortali F5WWR9.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAK28726 ; BAK28726 ; SGGB_1870 .
GeneIDi 12631077.
KEGGi sgt:SGGB_1870.

Phylogenomic databases

KOi K01775.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci SGAL981539:GLL2-1940-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequencing and comparative genome analysis of two pathogenic Streptococcus gallolyticus subspecies: genome plasticity, adaptation and virulence."
    Lin I.-H., Liu T.-T., Teng Y.-T., Wu H.-L., Liu Y.-M., Wu K.-M., Chang C.-H., Hsu M.-T.
    PLoS ONE 6:E20519-E20519(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43143 / F-1867Imported.

Entry informationi

Entry nameiF5WWR9_STRG1
AccessioniPrimary (citable) accession number: F5WWR9
Entry historyi
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3