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F5WV83

- F5WV83_ERYRF

UniProt

F5WV83 - F5WV83_ERYRF

Protein

Thymidine kinase

Gene

tdk

Organism
Erysipelothrix rhusiopathiae (strain Fujisawa)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 16 (01 Oct 2014)
      Sequence version 1 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei90 – 901Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi16 – 238ATPUniRule annotation
    Nucleotide bindingi89 – 924ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    DNA synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciERHU650150:GHGV-1689-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotationImported
    Ordered Locus Names:ERH_1613Imported
    OrganismiErysipelothrix rhusiopathiae (strain Fujisawa)Imported
    Taxonomic identifieri650150 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesErysipelotrichiaErysipelotrichalesErysipelotrichaceaeErysipelothrix
    ProteomesiUP000007944: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliF5WV83.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    KOiK00857.

    Family and domain databases

    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    F5WV83-1 [UniParc]FASTAAdd to Basket

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    MMYHQYQEGY IEVITGCMFA GKTEELIRRI NVLKFAHKNI IVFKPAVDNR    50
    YSDSKVVSHA GTSVQSVVVD KATDILKYVT KETDVVAIDE VQFFDEEIVK 100
    VCDHLALEGK RVMVAGLDMD FRGEPFGVIP KLMTTAEFVT KLTAVCTECG 150
    APATRTQRLV NGKPASYHDP VVMIGASESY EARCRHDHIV LDKPQINGNS 200
    EGDK 204
    Length:204
    Mass (Da):22,728
    Last modified:July 27, 2011 - v1
    Checksum:i2641D86303AFE8A0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP012027 Genomic DNA. Translation: BAK32665.1.
    RefSeqiYP_004561706.1. NC_015601.1.

    Genome annotation databases

    EnsemblBacteriaiBAK32665; BAK32665; ERH_1613.
    GeneIDi10755769.
    KEGGierh:ERH_1613.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP012027 Genomic DNA. Translation: BAK32665.1 .
    RefSeqi YP_004561706.1. NC_015601.1.

    3D structure databases

    ProteinModelPortali F5WV83.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAK32665 ; BAK32665 ; ERH_1613 .
    GeneIDi 10755769.
    KEGGi erh:ERH_1613.

    Phylogenomic databases

    KOi K00857.

    Enzyme and pathway databases

    BioCyci ERHU650150:GHGV-1689-MONOMER.

    Family and domain databases

    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Erysipelothrix rhusiopathiae, the causative agent of swine erysipelas, reveals new insights into the evolution of firmicutes and the organism's intracellular adaptations."
      Ogawa Y., Ooka T., Shi F., Ogura Y., Nakayama K., Hayashi T., Shimoji Y.
      J. Bacteriol. 193:2959-2971(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: FujisawaImported.

    Entry informationi

    Entry nameiF5WV83_ERYRF
    AccessioniPrimary (citable) accession number: F5WV83
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 27, 2011
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 16 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3