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F5HIR5

- F5HIR5_ANOGA

UniProt

F5HIR5 - F5HIR5_ANOGA

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Protein
Histone-lysine N-methyltransferase, H3 lysine-79 specific
Gene
AgaP_AGAP003282
Organism
Anopheles gambiae (African malaria mosquito)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionineUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
    Alternative name(s):
    Histone H3-K79 methyltransferase
    Gene namesi
    ORF Names:AgaP_AGAP003282Imported
    OrganismiAnopheles gambiae (African malaria mosquito)
    Taxonomic identifieri7165 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
    ProteomesiUP000007062: Chromosome 2R

    Subcellular locationi

    Nucleus By similarity UniRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    NucleusUniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 DOT1 domain.UniRule annotation

    Phylogenomic databases

    KOiK11427.
    OrthoDBiEOG7W6WJV.
    PhylomeDBiF5HIR5.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR013110. DOT1.
    IPR025789. Histone_H3-K79_MeTrfase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF08123. DOT1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51569. DOT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F5HIR5-1 [UniParc]FASTAAdd to Basket

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    MATPNYKELK LQSPAGAEPF LYNFPFSTVM GTGHDSGAEL IENVRWVCED     50
    MPEIKSAIEE IDLNNLDTNN YDAMKNLCDR FNRAIDSVAA LEKGTSLSNQ 100
    RFTYPSRGLL KHILQQVYNQ AVVEPEKLNQ YEPFSPEVYG ETSFDLICQM 150
    IDQVKITADD VFVDLGSGVG QVVLQMAAST PVKVCFGIEK ADVPSKYAEG 200
    MNTTFKLWMR WFGKKYGDYE LIKGDFLADE YREKITSATI VFVNNFAFGP 250
    NVDHQLKERF ADLRDGARIV SSKSFCPLNF RITDRNLSDI GTIMHVSEMS 300
    PLRGSVSWTG KPVSYYLHII DRTKLERYFQ RLKTKGTENH TDGTSGGGSG 350
    SHSTRSSRSR KDNNTNHHHH HPKVITNDDS TSESDTDVVG PTTRKAWSDW 400
    NSGKEGKTSP SEEENNNSPV LRNGRIPVAT KKRRKITRTK AAGKKAELAA 450
    ASAAAAAAAA AAAAAANRDM GVGTSAASAA AAAAAAMAGG KKRGRVKGKG 500
    RQRRPLNIAG LDLLHNETLL STSEQMIGKR LPPAPGCVDQ QLTSLAGDMQ 550
    HNELDIPEAP SETPYALQIL LDLYKTQFMK TIEAMRKPSY KDNVQQQFDR 600
    EKERNQRLMN RAGQLEKQIK VLIDDSVALL KARMNELGIS TTSQNDLLCK 650
    AKEIVGRHKE LQVMAAKLQN QVNVIEQEQK RLVMQHLTKL TVEQQQQHQQ 700
    QQQHQQLHPH QPYIKQEDAE LTSSSSNELV LKAIASTLSQ RKKLYAQVSN 750
    LETELNLIEK LTEERKSMVV GLSAAAPNSN HNSASSTAAA AAAAATSTII 800
    SVARATEVRD REQYGHAGQL HPATIGGGRE REHIHPDGTT TSKHTSDPVR 850
    TLPAGAAAGP VGVAGSAAPL PPPPMAGVGS ASVTVPSTPT KQGSGGGSSR 900
    SAQRKSRENR TRSQEWPEIP DIGKIEENNP EILAQKILET GRQIEAGKLF 950
    AAGKHASKER SSEGKLAPVV TAGHGSSAAA GTAAPQHIAH PPTVGAPAPQ 1000
    QQPYPHHHQQ PHSQPSQPPV HPHLHHPDTA LMPAPASTIN KAHHHHRSNS 1050
    GGPSGAVPPP VPTGGGSLPK CFVPGTASNE HHSGGGRNAP EGASGTGRGG 1100
    GSGGGGGGGK LQDSHKVVNF EDRLKSIITS VLQGSPKTGN TASSASAPVS 1150
    LTVTGPPPAG PSPGAGHRDA HHRSGSGGHQ PLTMEPAGSP LKATSASGAG 1200
    YGSAAGPGKT TVYLQSSPGA GSHHPHQMVV AQDMSARSST GGRGPSPSAH 1250
    NPAHQQQIHP HQVSQSQYQQ QQQLLHHPHH PHAQQSLHHQ QQQHQHYQMQ 1300
    QQQQHQHQQQ QQGMLNVITS GAHHLNASTS ISTSPVPTSP YKMHPTGPPA 1350
    SSIAGSASTK ISPSSKYPYP KGGPVAGMSH HSPGSSALST HQQIIQQQER 1400
    ERAMLYAAAA HGGGLPIDHP HHPLHQHHHR GMPPSLVDGK MLEFKAPENF 1450
    RYDPRASGPS GAAGNGPPML DTSAVSLQSH SRSSSTNSLD SIPAADYGPA 1500
    SAGASAVGGG GARYGGQQQP IPLVTHSPGV GSQGSGQQHG GNNSRPGSTS 1550
    SQPDYTQVSP AKMALRRHLS QEKLTHPSAG GPAAGGPVSG GTGAGGSGGG 1600
    LGTVKTIGDL VNGEIERTLE ISNQSIINAA INMSSHQQQQ QSSAASGNSS 1650
    APSASGNNTV INTHVQRPER VSIRLLEEAG HAAAGGPPPP GSSGGTYSPI 1700
    SRPGSVGDSG SKSPVHHLHG QSNLASLVQV SAYNSKNHKG AGTTAVPSTI 1750
    VSPRGGGSSQ QQQHQQYSTA QGSGAAGGPG AVYQQSTSRG HDRHHSGEPM 1800
    PYMALPRADM KPYLESYFTD EHNKRQQQLH QQQQQHQQHP QHQQQHQQQH 1850
    LQHPVQSPSP SAMSASAMGL HHHQQQQMHH QHAPLAMHRA SHPVDLHRGS 1900
    VVMNEPGMLS RSRGEMIPMD DNRMDRLNGG PPLEGLAASL QARVIATLKI 1950
    KEEDEERHRR DLSIHHSTSG TINSSSNSIN STNSNIHGGS LQIVQTAHIK 2000
    SEKYTSSSSS SSTSSTSSTS SHHHHALKRT SPIVEHPAGT RPPKMLYTTS 2050
    ASAGGMDCGP DADMLHVPRG TVPGSSVVGH SAVRGGLLVA PPLVMSPEIN 2100
    SLSSVVDDGR HHHQLHVRHN HHSRNDVDDD VVIGDDESSW HDRVSSGFDR 2150
    LVAFASTELD KTRRSNEDAP ASSASCTTSP DSGINQSDHS RTFLSSSSSS 2200
    SQLDVPPGSA SVGSSSSSSI SSSSSSNSST SSIGSVTGGH GGGSGGSHGV 2250
    GGHAGVPGGL MMKHMVPIIK SSPAEPVDSP PLSDVGLPRT PSPTSSPPLL 2300
    FGHPTASSTA IAGGATTSAV STVMQPSLLH PPVVGGHAPV AGSGNNNGVV 2350
    PPAAGSAAPV NNSNSGNSSS SSSSLGIPLK YQRQSKSSSS SSEKHYKKKF 2400
    RERNWEEYEE SLSGGRNSAI SGSGDVPMDQ QDYHHTVASL NAPHSGSMDV 2450
    GNASAPSSST SMSAEPIGSA VGDKRNDDHA AQHHHQQQQQ QQQQQQQQHH 2500
    HKHKSAKFRP KGKDWNWDDE HLNASSGSAT STRGAGRSGT NTAST 2545
    Length:2,545
    Mass (Da):268,957
    Last modified:July 27, 2011 - v1
    Checksum:iF8BF3D8C7076E487
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAAB01008794 Genomic DNA. Translation: EGK96176.1.
    RefSeqiXP_003436434.1. XM_003436386.1.

    Genome annotation databases

    EnsemblMetazoaiAGAP003282-RB; AGAP003282-PB; AGAP003282.
    GeneIDi1269184.
    KEGGiaga:AgaP_AGAP003282.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAAB01008794 Genomic DNA. Translation: EGK96176.1 .
    RefSeqi XP_003436434.1. XM_003436386.1.

    3D structure databases

    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai AGAP003282-RB ; AGAP003282-PB ; AGAP003282 .
    GeneIDi 1269184.
    KEGGi aga:AgaP_AGAP003282.

    Phylogenomic databases

    KOi K11427.
    OrthoDBi EOG7W6WJV.
    PhylomeDBi F5HIR5.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR013110. DOT1.
    IPR025789. Histone_H3-K79_MeTrfase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF08123. DOT1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51569. DOT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of the malaria mosquito Anopheles gambiae."
      Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F.
      , Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.
      Science 298:129-149(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PESTImported.

    Entry informationi

    Entry nameiF5HIR5_ANOGA
    AccessioniPrimary (citable) accession number: F5HIR5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 27, 2011
    Last sequence update: July 27, 2011
    Last modified: September 3, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Miscellaneous

    In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones By similarity.UniRule annotation

    Caution

    The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteome

    External Data

    Dasty 3

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