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F5HIR5

- F5HIR5_ANOGA

UniProt

F5HIR5 - F5HIR5_ANOGA

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Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene

AgaP_AGAP003282

Organism
Anopheles gambiae (African malaria mosquito)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Alternative name(s):
Histone H3-K79 methyltransferaseUniRule annotation
Gene namesi
ORF Names:AgaP_AGAP003282Imported
OrganismiAnopheles gambiae (African malaria mosquito)Imported
Taxonomic identifieri7165 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
ProteomesiUP000007062: Chromosome 2R

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.UniRule annotation
Contains 1 DOT1 domain.UniRule annotation

Phylogenomic databases

InParanoidiF5HIR5.
KOiK11427.
OrthoDBiEOG7W6WJV.
PhylomeDBiF5HIR5.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F5HIR5-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MATPNYKELK LQSPAGAEPF LYNFPFSTVM GTGHDSGAEL IENVRWVCED
60 70 80 90 100
MPEIKSAIEE IDLNNLDTNN YDAMKNLCDR FNRAIDSVAA LEKGTSLSNQ
110 120 130 140 150
RFTYPSRGLL KHILQQVYNQ AVVEPEKLNQ YEPFSPEVYG ETSFDLICQM
160 170 180 190 200
IDQVKITADD VFVDLGSGVG QVVLQMAAST PVKVCFGIEK ADVPSKYAEG
210 220 230 240 250
MNTTFKLWMR WFGKKYGDYE LIKGDFLADE YREKITSATI VFVNNFAFGP
260 270 280 290 300
NVDHQLKERF ADLRDGARIV SSKSFCPLNF RITDRNLSDI GTIMHVSEMS
310 320 330 340 350
PLRGSVSWTG KPVSYYLHII DRTKLERYFQ RLKTKGTENH TDGTSGGGSG
360 370 380 390 400
SHSTRSSRSR KDNNTNHHHH HPKVITNDDS TSESDTDVVG PTTRKAWSDW
410 420 430 440 450
NSGKEGKTSP SEEENNNSPV LRNGRIPVAT KKRRKITRTK AAGKKAELAA
460 470 480 490 500
ASAAAAAAAA AAAAAANRDM GVGTSAASAA AAAAAAMAGG KKRGRVKGKG
510 520 530 540 550
RQRRPLNIAG LDLLHNETLL STSEQMIGKR LPPAPGCVDQ QLTSLAGDMQ
560 570 580 590 600
HNELDIPEAP SETPYALQIL LDLYKTQFMK TIEAMRKPSY KDNVQQQFDR
610 620 630 640 650
EKERNQRLMN RAGQLEKQIK VLIDDSVALL KARMNELGIS TTSQNDLLCK
660 670 680 690 700
AKEIVGRHKE LQVMAAKLQN QVNVIEQEQK RLVMQHLTKL TVEQQQQHQQ
710 720 730 740 750
QQQHQQLHPH QPYIKQEDAE LTSSSSNELV LKAIASTLSQ RKKLYAQVSN
760 770 780 790 800
LETELNLIEK LTEERKSMVV GLSAAAPNSN HNSASSTAAA AAAAATSTII
810 820 830 840 850
SVARATEVRD REQYGHAGQL HPATIGGGRE REHIHPDGTT TSKHTSDPVR
860 870 880 890 900
TLPAGAAAGP VGVAGSAAPL PPPPMAGVGS ASVTVPSTPT KQGSGGGSSR
910 920 930 940 950
SAQRKSRENR TRSQEWPEIP DIGKIEENNP EILAQKILET GRQIEAGKLF
960 970 980 990 1000
AAGKHASKER SSEGKLAPVV TAGHGSSAAA GTAAPQHIAH PPTVGAPAPQ
1010 1020 1030 1040 1050
QQPYPHHHQQ PHSQPSQPPV HPHLHHPDTA LMPAPASTIN KAHHHHRSNS
1060 1070 1080 1090 1100
GGPSGAVPPP VPTGGGSLPK CFVPGTASNE HHSGGGRNAP EGASGTGRGG
1110 1120 1130 1140 1150
GSGGGGGGGK LQDSHKVVNF EDRLKSIITS VLQGSPKTGN TASSASAPVS
1160 1170 1180 1190 1200
LTVTGPPPAG PSPGAGHRDA HHRSGSGGHQ PLTMEPAGSP LKATSASGAG
1210 1220 1230 1240 1250
YGSAAGPGKT TVYLQSSPGA GSHHPHQMVV AQDMSARSST GGRGPSPSAH
1260 1270 1280 1290 1300
NPAHQQQIHP HQVSQSQYQQ QQQLLHHPHH PHAQQSLHHQ QQQHQHYQMQ
1310 1320 1330 1340 1350
QQQQHQHQQQ QQGMLNVITS GAHHLNASTS ISTSPVPTSP YKMHPTGPPA
1360 1370 1380 1390 1400
SSIAGSASTK ISPSSKYPYP KGGPVAGMSH HSPGSSALST HQQIIQQQER
1410 1420 1430 1440 1450
ERAMLYAAAA HGGGLPIDHP HHPLHQHHHR GMPPSLVDGK MLEFKAPENF
1460 1470 1480 1490 1500
RYDPRASGPS GAAGNGPPML DTSAVSLQSH SRSSSTNSLD SIPAADYGPA
1510 1520 1530 1540 1550
SAGASAVGGG GARYGGQQQP IPLVTHSPGV GSQGSGQQHG GNNSRPGSTS
1560 1570 1580 1590 1600
SQPDYTQVSP AKMALRRHLS QEKLTHPSAG GPAAGGPVSG GTGAGGSGGG
1610 1620 1630 1640 1650
LGTVKTIGDL VNGEIERTLE ISNQSIINAA INMSSHQQQQ QSSAASGNSS
1660 1670 1680 1690 1700
APSASGNNTV INTHVQRPER VSIRLLEEAG HAAAGGPPPP GSSGGTYSPI
1710 1720 1730 1740 1750
SRPGSVGDSG SKSPVHHLHG QSNLASLVQV SAYNSKNHKG AGTTAVPSTI
1760 1770 1780 1790 1800
VSPRGGGSSQ QQQHQQYSTA QGSGAAGGPG AVYQQSTSRG HDRHHSGEPM
1810 1820 1830 1840 1850
PYMALPRADM KPYLESYFTD EHNKRQQQLH QQQQQHQQHP QHQQQHQQQH
1860 1870 1880 1890 1900
LQHPVQSPSP SAMSASAMGL HHHQQQQMHH QHAPLAMHRA SHPVDLHRGS
1910 1920 1930 1940 1950
VVMNEPGMLS RSRGEMIPMD DNRMDRLNGG PPLEGLAASL QARVIATLKI
1960 1970 1980 1990 2000
KEEDEERHRR DLSIHHSTSG TINSSSNSIN STNSNIHGGS LQIVQTAHIK
2010 2020 2030 2040 2050
SEKYTSSSSS SSTSSTSSTS SHHHHALKRT SPIVEHPAGT RPPKMLYTTS
2060 2070 2080 2090 2100
ASAGGMDCGP DADMLHVPRG TVPGSSVVGH SAVRGGLLVA PPLVMSPEIN
2110 2120 2130 2140 2150
SLSSVVDDGR HHHQLHVRHN HHSRNDVDDD VVIGDDESSW HDRVSSGFDR
2160 2170 2180 2190 2200
LVAFASTELD KTRRSNEDAP ASSASCTTSP DSGINQSDHS RTFLSSSSSS
2210 2220 2230 2240 2250
SQLDVPPGSA SVGSSSSSSI SSSSSSNSST SSIGSVTGGH GGGSGGSHGV
2260 2270 2280 2290 2300
GGHAGVPGGL MMKHMVPIIK SSPAEPVDSP PLSDVGLPRT PSPTSSPPLL
2310 2320 2330 2340 2350
FGHPTASSTA IAGGATTSAV STVMQPSLLH PPVVGGHAPV AGSGNNNGVV
2360 2370 2380 2390 2400
PPAAGSAAPV NNSNSGNSSS SSSSLGIPLK YQRQSKSSSS SSEKHYKKKF
2410 2420 2430 2440 2450
RERNWEEYEE SLSGGRNSAI SGSGDVPMDQ QDYHHTVASL NAPHSGSMDV
2460 2470 2480 2490 2500
GNASAPSSST SMSAEPIGSA VGDKRNDDHA AQHHHQQQQQ QQQQQQQQHH
2510 2520 2530 2540
HKHKSAKFRP KGKDWNWDDE HLNASSGSAT STRGAGRSGT NTAST
Length:2,545
Mass (Da):268,957
Last modified:July 27, 2011 - v1
Checksum:iF8BF3D8C7076E487
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAAB01008794 Genomic DNA. Translation: EGK96176.1.
RefSeqiXP_003436434.1. XM_003436386.1.

Genome annotation databases

EnsemblMetazoaiAGAP003282-RB; AGAP003282-PB; AGAP003282.
GeneIDi1269184.
KEGGiaga:AgaP_AGAP003282.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAAB01008794 Genomic DNA. Translation: EGK96176.1 .
RefSeqi XP_003436434.1. XM_003436386.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai AGAP003282-RB ; AGAP003282-PB ; AGAP003282 .
GeneIDi 1269184.
KEGGi aga:AgaP_AGAP003282.

Phylogenomic databases

InParanoidi F5HIR5.
KOi K11427.
OrthoDBi EOG7W6WJV.
PhylomeDBi F5HIR5.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF08123. DOT1. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51569. DOT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the malaria mosquito Anopheles gambiae."
    Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M., Wides R., Salzberg S.L., Loftus B., Yandell M., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F.
    , Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C., Kokoza E., Koutsos A., Letunic I., Levitsky A., Liang Y., Lin J.J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z., Unger M.F., Walenz B., Wang A., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.
    Science 298:129-149(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PESTImported.

Entry informationi

Entry nameiF5HIR5_ANOGA
AccessioniPrimary (citable) accession number: F5HIR5
Entry historyi
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3