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Protein

Triplex capsid protein 2

Gene

TRX2

Organism
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Structural component of the T=16 icosahedral capsid. The capsid is composed of pentamers and hexamers of major capsid protein/MCP, which are linked together by heterotrimers called triplexes. These triplexes are formed by a single molecule of triplex protein 1/TRX1 and two copies of triplex protein 2/TRX2. Additionally, TRX1 is required for efficient transport of TRX2 to the nucleus, which is the site of capsid assembly.UniRule annotation

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Triplex capsid protein 2UniRule annotation
Gene namesi
Name:TRX2UniRule annotation
Ordered Locus Names:UL85
OrganismiHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri295027 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000938 Componenti: Genome

Subcellular locationi

  • Virion UniRule annotation
  • Host nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004182571 – 306Triplex capsid protein 2Add BLAST306

Interactioni

Subunit structurei

Interacts with TRX1 and major capisd protein/MCP.UniRule annotation

Structurei

3D structure databases

SMRiF5HIN9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae TRX2 protein family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG090000IF.

Family and domain databases

HAMAPiMF_04019. HSV_TRX2. 1 hit.
InterProiView protein in InterPro
IPR002690. Herpes_capsid_2.
PfamiView protein in Pfam
PF01802. Herpes_V23. 1 hit.

Sequencei

Sequence statusi: Complete.

F5HIN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAMEANIFC TFDHKLSIAD VGKLTKLVAA VVPIPQRLHL IKHYQLGLHQ
60 70 80 90 100
FVDHTRGYVR LRGLLRNMTL TLMRRVEGNQ ILLHVPTHGL LYTVLNTGPV
110 120 130 140 150
TWEKGDALCV LPPLFHGPLA RENLLTLGQW ELVLPWIVPM PLALEINQRL
160 170 180 190 200
LIMGLFSLDR SYEEVKAAVQ QLQTITFRDA TFTIPDPVID QHLLIDMKTA
210 220 230 240 250
CLSMSMVANL ASELTMTYVR KLALEDSSML LVKCQELLMR LDRERSVGEP
260 270 280 290 300
RTPARPQHVS PDDEIARLSA LFVMLRQLDD LIREQVVFTV CDVSPDNKSA

TCIFKG
Length:306
Mass (Da):34,595
Last modified:June 28, 2011 - v1
Checksum:i89A4E0FFE36B56C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY446894 Genomic DNA. Translation: AAR31637.1.
RefSeqiYP_081533.1. NC_006273.2.

Genome annotation databases

GeneIDi3077516.
KEGGivg:3077516.

Similar proteinsi

Entry informationi

Entry nameiTRX2_HCMVM
AccessioniPrimary (citable) accession number: F5HIN9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2012
Last sequence update: June 28, 2011
Last modified: October 25, 2017
This is version 14 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families