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Protein

Uracil-DNA glycosylase

Gene

UL114

Organism
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or deamination of cytosines. Therefore may reduce deleterious uracil incorporation into the viral genome, particularly in terminally differentiated cells which lack DNA repair enzymes.UniRule annotation

Catalytic activityi

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei91Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processDNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil-DNA glycosylaseUniRule annotation (EC:3.2.2.27UniRule annotation)
Short name:
UDGUniRule annotation
Alternative name(s):
UNGUniRule annotation
Gene namesi
Name:UL114
OrganismiHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri295027 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000938 Componenti: Genome

Subcellular locationi

  • Host nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004164391 – 250Uracil-DNA glycosylaseAdd BLAST250

Proteomic databases

PRIDEiF5HI85

Interactioni

Protein-protein interaction databases

BioGridi1678092, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliF5HI85
SMRiF5HI85
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi110 – 113Poly-Pro4

Sequence similaritiesi

Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG090000E7

Family and domain databases

CDDicd10027 UDG_F1, 1 hit
Gene3Di3.40.470.10, 1 hit
HAMAPiMF_00148 UDG, 1 hit
InterProiView protein in InterPro
IPR002043 UDG_fam1
IPR018085 Ura-DNA_Glyclase_AS
IPR005122 Uracil-DNA_glycosylase-like
IPR036895 Uracil-DNA_glycosylase-like_sf
PANTHERiPTHR11264 PTHR11264, 1 hit
PfamiView protein in Pfam
PF03167 UDG, 1 hit
SMARTiView protein in SMART
SM00986 UDG, 1 hit
SUPFAMiSSF52141 SSF52141, 1 hit
TIGRFAMsiTIGR00628 ung, 1 hit
PROSITEiView protein in PROSITE
PS00130 U_DNA_GLYCOSYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

F5HI85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALKQWMLAN IADNKGSLLT PDEQARVFCL SADWIRFLSL PDHDTVLLRD
60 70 80 90 100
TVAAVEGARQ LEMVYPAPEH VHRWSYLCPP EQVRVVIVGQ DPYCDGSASG
110 120 130 140 150
LAFGTLAGRP PPPSLNNVFR ELARTVDGFQ RPASGCLDAW ARRGVLLLNT
160 170 180 190 200
VFTVVHGQPG SHRHLGWQTL SNHVIRRLSE RREHLVFMLW GADAHTCEYL
210 220 230 240 250
IDRRRHLVLK SCHPSPRNTT RAFVGNDHFI LANAYLDTHY RETMDWRLCG
Length:250
Mass (Da):28,353
Last modified:June 28, 2011 - v1
Checksum:i0CC28AC4DC155508
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY446894 Genomic DNA Translation: AAR31658.1
RefSeqiYP_081554.1, NC_006273.2

Genome annotation databases

GeneIDi3077539
KEGGivg:3077539

Similar proteinsi

Entry informationi

Entry nameiUNG_HCMVM
AccessioniPrimary (citable) accession number: F5HI85
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: June 28, 2011
Last modified: May 23, 2018
This is version 24 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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