Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Membrane glycoprotein UL142

Gene

UL142

Organism
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Participates in the inhibition of the host immune response. Prevents host NK cell-mediated lysis of the infected cell by preventing the KLRK1 ligand 3/ULBP3 trafficking to the cell surface. Retains also another KLRK1 ligand, MHC class I-related chain A/MICA, in the Golgi apparatus to avoid its surface expression.3 Publications

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane glycoprotein UL142
Gene namesi
Name:UL142
OrganismiHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri295027 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000938 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 270LumenalSequence analysisAdd BLAST251
Transmembranei271 – 288HelicalSequence analysisAdd BLAST18
Topological domaini289 – 305CytoplasmicSequence analysisAdd BLAST17

GO - Cellular componenti

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000041830320 – 305Membrane glycoprotein UL142Add BLAST286

Interactioni

Subunit structurei

Interacts with host MICA and ULBP3.2 Publications

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi127 – 267Thr-richAdd BLAST141

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK21048.
OrthoDBiVOG090000JV.

Family and domain databases

Gene3Di3.30.500.10. 1 hit.
InterProiView protein in InterPro
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
SUPFAMiSSF54452. SSF54452. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

F5HHH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIEWACWLF GYFVSSVGSE RSLSYRYHLE SNSSANVVCN GNISVFVNGT
60 70 80 90 100
LGVRYNITVG ISSSLLIGHL TIQTLESWFT PWVQNKSYSK QPLSTTETLY
110 120 130 140 150
NIDSENIHRV SQYFHTRWIK SLQENHTCDL TNSTPTYTYQ ANVNNTNYLT
160 170 180 190 200
LTSSGWQDRL NYTAINSTHF NLTESNITSI HKYLNTTCIE RLRNYTLEPV
210 220 230 240 250
YTTAVPQNVT PEHAITTLYT TPPNAITIKD TTQSHTVQTP SFNDTHNVTE
260 270 280 290 300
HTLNISYVLS QKTNNTTSPW VYAIPMGATA TIGAGLYIGK HFTPVKFVYE

VWRGQ
Length:305
Mass (Da):34,626
Last modified:June 28, 2011 - v1
Checksum:i6E67EFD0E22B8F5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY446894 Genomic DNA. Translation: AAR31678.1.
RefSeqiYP_081574.1. NC_006273.2.

Genome annotation databases

GeneIDi3077552.
KEGGivg:3077552.

Similar proteinsi

Entry informationi

Entry nameiUL142_HCMVM
AccessioniPrimary (citable) accession number: F5HHH2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2012
Last sequence update: June 28, 2011
Last modified: March 15, 2017
This is version 20 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome