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Protein

Histone deacetylase

Gene

CNBF1870

Organism
Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, HydrolaseUniRule annotationSAAS annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotation (EC:3.5.1.98UniRule annotation)
Gene namesi
Ordered Locus Names:CNBF1870Imported
OrganismiCryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)Imported
Taxonomic identifieri283643 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex
ProteomesiUP000001435 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiFungiDB:CNBF1870.

Subcellular locationi

  • Nucleus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi283643.XP_775024.1.

Structurei

3D structure databases

ProteinModelPortaliF5HH61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

KOiK06067.
OrthoDBiEOG78M0B2.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

F5HH61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSMEPILGE SKRRVCYFFD SDIGNYHYGP GHPMKPTRIR MCHSLVMNYG
60 70 80 90 100
LYKKMEIFRA KPATKREMSQ FHTDEYVDFL YRINPDNAAQ FAKEQVKYNV
110 120 130 140 150
GDDCPIFDGL FEYCSISAGG SMEGAARLSR DKCDIAVNWA GGLHHAKKAE
160 170 180 190 200
ASGFCYVNDI VLGILELLRY HQRVLYIDID VHHGDGVEEA FYTTDRVMTC
210 220 230 240 250
SFHKYGEFFP GTGEVRDNGI GKGKGYAINV PLRDGISDDN YKSIFQPVIK
260 270 280 290 300
RVIEWYQPGA VVLQCGSDSL SGDRLGSFNL SMKGHAACVQ FVKSFNLPLL
310 320 330 340 350
LLGGGGYTVK SVSRTWAYET GLAAGMELGR DLPNNEYWEY YGPDYELDVR
360 370 380 390 400
SSNMTDQNTP EYLQKVTEAV FEVLRDKNAA PSVPLQSIPK MMHDDEDEDE
410 420 430 440 450
GEDNEDRDVR RPARLWAREK QHETSLSDSE DEGTGGRRHR RSYKESAQKN
460
TMVEDQCNFR VNAGFT
Length:466
Mass (Da):52,756
Last modified:June 28, 2011 - v1
Checksum:i674E0DEE1CD0A8AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEY01000030 Genomic DNA. Translation: EAL20377.1.
RefSeqiXP_775024.1. XM_769931.1.

Genome annotation databases

GeneIDi4936739.
KEGGicnb:CNBF1870.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEY01000030 Genomic DNA. Translation: EAL20377.1.
RefSeqiXP_775024.1. XM_769931.1.

3D structure databases

ProteinModelPortaliF5HH61.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi283643.XP_775024.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4936739.
KEGGicnb:CNBF1870.

Organism-specific databases

EuPathDBiFungiDB:CNBF1870.

Phylogenomic databases

KOiK06067.
OrthoDBiEOG78M0B2.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNetiSearch...

Publicationsi

  1. "The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans."
    Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S.
    , Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C., Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K., Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.
    Science 307:1321-1324(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: B-3501AImported.

Entry informationi

Entry nameiF5HH61_CRYNB
AccessioniPrimary (citable) accession number: F5HH61
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: June 24, 2015
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.