Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Major capsid protein

Gene

MCP

Organism
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Self-assembles to form an icosahedral capsid with a T=16 symmetry, about 200 nm in diameter, and consisting of 150 hexons and 12 pentons (total of 162 capsomers). Hexons form the edges and faces of the capsid and are each composed of six MCP molecules. In contrast, one penton is found at each of the 12 vertices. Eleven of the pentons are MCP pentamers, while the last vertex is occupied by the portal complex. The capsid is surrounded by a layer of proteinaceous material designated the tegument which, in turn, is enclosed in an envelope of host cell-derived lipids containing virus-encoded glycoproteins.UniRule annotation

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Major capsid proteinUniRule annotation
Short name:
MCPUniRule annotation
Gene namesi
Name:MCPUniRule annotation
Synonyms:UL86
OrganismiHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri295027 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000938 Componenti: Genome

Subcellular locationi

  • Virion UniRule annotation
  • Host nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Host nucleus, T=16 icosahedral capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004182371 – 1370Major capsid proteinAdd BLAST1370

Interactioni

Subunit structurei

Homomultimer. Makes the hexons and eleven out of twelve pentons. Interacts with triplex proteins 1/TRX1 and 2/TRX2; adjacent capsomers are linked together in groups of three by triplexes, heterotrimeric complexes composed of one molecule of TRX1 and two molecules of TRX2. Interacts with scaffold protein; this interaction allows efficient MCP transport to the host nucleus. Interacts with capsid vertex component 2/CVC2. Interacts with the small capsomere-interacting protein/SCP.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliF5HGT1.
SMRiF5HGT1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi72 – 77Poly-Ala6

Sequence similaritiesi

Belongs to the herpesviridae major capsid protein family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG0900000D.

Family and domain databases

HAMAPiMF_04016. HSV_MCP. 1 hit.
InterProiView protein in InterPro
IPR000912. Herpes_MCP.
IPR023233. Herpes_MCP_upper_sf.
PfamiView protein in Pfam
PF03122. Herpes_MCP. 1 hit.
PRINTSiPR00235. HSVCAPSIDMCP.
SUPFAMiSSF103417. SSF103417. 1 hit.

Sequencei

Sequence statusi: Complete.

F5HGT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENWSALELL PKVGIPTDFL THVKTSAGEE MFEALRIYYG DDPERYNIHF
60 70 80 90 100
EAIFGTFCNR LEWVYFLTSG LAAAAHAIKF HDLNKLTTGK MLFHVQVPRV
110 120 130 140 150
ASGAGLPTSR QTTIMVTKYS EKSPITIPFE LSAACLTYLR ETFEGTILDK
160 170 180 190 200
ILNVEAMHTV LRALKNTADA MERGLIHSFL QTLLRKAPPY FVVQTLVENA
210 220 230 240 250
TLARQALNRI QRSNILQSFK AKMLATLFLL NRTRDRDYVL KFLTRLAEAA
260 270 280 290 300
TDSILDNPTT YTTSSGAKIS GVMVSTANVM QIIMSLLSSH ITKETVSAPA
310 320 330 340 350
TYGNFVLSPE NAVTAISYHS ILADFNSYKA HLTSGQPHLP NDSLSQAGAH
360 370 380 390 400
SLTPLSMDVI RLGEKTVIME NLRRVYKNTD TKDPLERNVD LTFFFPVGLY
410 420 430 440 450
LPEDRGYTTV ESKVKLNDTV RNALPTTAYL LNRDRAVQKI DFVDALKTLC
460 470 480 490 500
HPVLHEPAPC LQTFTERGPP SEPAMQRLLE CRFQQEPMGG AARRIPHFYR
510 520 530 540 550
VRREVPRTVN EMKQDFVVTD FYKVGNITLY TELHPFFDFT HCQENSETVA
560 570 580 590 600
LCTPRIVIGN LPDGLAPGPF HELRTWEIME HMRLRPPPDY EETLRLFKTT
610 620 630 640 650
VTSPNYPELC YLVDVLVHGN VDAFLLIRTF VARCIVNMFH TRQLLVFAHS
660 670 680 690 700
YALVTLIAEH LADGALPPQL LFHYRNLVAV LRLVTRISAL PGLNNGQLAE
710 720 730 740 750
EPLSAYVNAL HDHRLWPPFV THLPRNMEGV QVVADRQPLN PANIEARHHG
760 770 780 790 800
VSDVPRLGAM DADEPLFVDD YRATDDEWTL QKVFYLCLMP AMTNNRACGL
810 820 830 840 850
GLNLKTLLVD LFYRPAFLLM PAATAVSTSG TTSKESTSGV TPEDSIAAQR
860 870 880 890 900
QAVGEMLTEL VEDVATDAHT PLLQACRELF LAVQFVGEHV KVLEVRAPLD
910 920 930 940 950
HAQRQGLPDF ISRQHVLYNG CCVVTAPKTL IEYSLPVPFH RFYSNPTICA
960 970 980 990 1000
ALSDDIKRYV TEFPHYHRHD GGFPLPTAFA HEYHNWLRSP FSRYSATCPN
1010 1020 1030 1040 1050
VLHSVMTLAA MLYKISPVSL VLQTKAHIHP GFALTAVRTD TFEVDMLLYS
1060 1070 1080 1090 1100
GKSCTSVIIN NPIVTKEERD ISTTYHVTQN INTVDMGLGY TSNTCVAYVN
1110 1120 1130 1140 1150
RVRTDMGVRV QDLFRVFPMN VYRHDEVDRW IRHAAGVERP QLLDTETISM
1160 1170 1180 1190 1200
LTFGSMSERN AAATVHGQKA ACELILTPVT MDVNYFKIPN NPRGRASCML
1210 1220 1230 1240 1250
AVDPYDTEAA TKAIYDHREA DAQTFAATHN PWASQAGCLS DVLYNTRHRE
1260 1270 1280 1290 1300
RLGYNSKFYS PCAQYFNTEE IIAANKTLFK TIDEYLLRAK DCIRGDTDTQ
1310 1320 1330 1340 1350
YVCVEGTEQL IENPCRLTQE ALPILSTTTL ALMETKLKGG AGAFATSETH
1360 1370
FGNYVVGEII PLQQSMLFNS
Length:1,370
Mass (Da):153,872
Last modified:June 28, 2011 - v1
Checksum:i5EEFCEE4D7498E8D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY446894 Genomic DNA. Translation: AAR31638.1.
RefSeqiYP_081534.1. NC_006273.2.

Genome annotation databases

GeneIDi3077538.
KEGGivg:3077538.

Similar proteinsi

Entry informationi

Entry nameiMCP_HCMVM
AccessioniPrimary (citable) accession number: F5HGT1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2012
Last sequence update: June 28, 2011
Last modified: November 22, 2017
This is version 18 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families